-
1
-
-
84855698516
-
-
accessed 3/22/2011
-
http://www.nccn.org/professionals/physician-gls/pdf/nscl.pdf, accessed 3/22/2011.
-
-
-
-
3
-
-
20544455590
-
Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
-
DOI 10.1056/NEJMoa043623
-
T Winton R Livingston D Johnson, et al. 2005 Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer N Engl J Med 352 2589 2597 15972865 10.1056/NEJMoa043623 1:CAS:528:DC%2BD2MXls1Wqurg%3D (Pubitemid 41007845)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.25
, pp. 2589-2597
-
-
Winton, T.1
Livingston, R.2
Johnson, D.3
Rigas, J.4
Johnston, M.5
Butts, C.6
Cormier, Y.7
Goss, G.8
Inculet, R.9
Vallieres, E.10
Fry, W.11
Bethune, D.12
Ayoub, J.13
Ding, K.14
Seymour, L.15
Graham, B.16
Tsao, M.-S.17
Gandara, D.18
Kesler, K.19
Demmy, T.20
Shepherd, F.21
more..
-
4
-
-
33747847740
-
Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): A randomised controlled trial
-
DOI 10.1016/S1470-2045(06)70804-X, PII S147020450670804X
-
J-Y Douillard R Rosell M De Lena, et al. 2006 Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomized controlled trial Lancet Oncol 7 719 727 16945766 10.1016/S1470-2045(06)70804-X 1:CAS:528:DC%2BD28Xptlyku7c%3D (Pubitemid 44283661)
-
(2006)
Lancet Oncology
, vol.7
, Issue.9
, pp. 719-727
-
-
Douillard, J.-Y.1
Rosell, R.2
De Lena, M.3
Carpagnano, F.4
Ramlau, R.5
Gonzales-Larriba, J.L.6
Grodzki, T.7
Pereira, J.R.8
Le Groumellec, A.9
Lorusso, V.10
Clary, C.11
Torres, A.J.12
Dahabreh, J.13
Souquet, P.-J.14
Astudillo, J.15
Fournel, P.16
Artal-Cortes, A.17
Jassem, J.18
Koubkova, L.19
His, P.20
Riggi, M.21
Hurteloup, P.22
more..
-
5
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
DOI 10.1016/S0140-6736(05)67625-8, PII S0140673605676258
-
N Thatcher A Chang P Parikh, et al. 2005 Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer) Lancet 366 1527 1537 16257339 10.1016/S0140-6736(05)67625-8 1:CAS:528:DC%2BD2MXhtFKhsbfP (Pubitemid 41540110)
-
(2005)
Lancet
, vol.366
, Issue.9496
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Pereira, J.R.4
Ciuleanu, T.5
Von Pawel, J.6
Thongprasert, S.7
Tan, E.H.8
Pemberton, K.9
Archer, V.10
Carroll, K.11
-
6
-
-
77958478674
-
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
-
20966921 10.1038/nrc2947 1:CAS:528:DC%2BC3cXhtlWlsrrN
-
W Pao J Chmielecki 2010 Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer Nat Rev Cancer 10 760 774 20966921 10.1038/nrc2947 1:CAS:528:DC%2BC3cXhtlWlsrrN
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 760-774
-
-
Pao, W.1
Chmielecki, J.2
-
7
-
-
24644458654
-
FDA drug approval summary: Erlotinib (Tarceva®) tablets
-
DOI 10.1634/theoncologist.10-7-461
-
MH Cohen JR Johnson Y-F Chen, et al. 2005 FDA drug approval summary: Erlotinib (Tarceva) Tablets Oncologist 7 461 466 10.1634/theoncologist.10-7-461 (Pubitemid 41266326)
-
(2005)
Oncologist
, vol.10
, Issue.7
, pp. 461-466
-
-
Cohen, M.H.1
Johnson, J.R.2
Chen, Y.-F.3
Sridhara, R.4
Pazdur, R.5
-
8
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
DOI 10.1056/NEJMoa050753
-
FA Shepherd JR Pereira T Ciuleanu, et al. 2005 Erlotinib in previously treated non-small-cell lung cancer N Engl J Med 353 123 132 16014882 10.1056/NEJMoa050753 1:CAS:528:DC%2BD2MXmtFaksbo%3D (Pubitemid 41058344)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Pereira, J.R.2
Ciuleanu, T.3
Eng, H.T.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van Kooten, M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
9
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
20573926 10.1056/NEJMoa0909530 1:CAS:528:DC%2BC3cXot1Gjt7Y%3D
-
M Maemondo A Inoue K Kobayashi, et al. 2010 Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR N Engl J Med 362 2380 2388 20573926 10.1056/NEJMoa0909530 1:CAS:528:DC%2BC3cXot1Gjt7Y%3D
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
10
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer horbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomized phase 3 trial
-
20022809 10.1016/S1470-2045(09)70364-X 1:CAS:528:DC%2BC3cXhtlGgtbo%3D
-
T Mitsudomi S Morita Y Yatabe, et al. 2010 Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer horbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomized phase 3 trial Lancet Oncol 11 121 128 20022809 10.1016/S1470-2045(09)70364-X 1:CAS:528:DC%2BC3cXhtlGgtbo%3D
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
11
-
-
77956267159
-
Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: Cancer and Leukemia Group B (CALEB) (sic) 30106, a CALGB-Stratified Phase II Trial
-
10.1097/JTO.0b013e3181eba657
-
N Ready P Janne J Bogart, et al. 2010 Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: Cancer And Leukemia Group B (CALEB) (sic) 30106, a CALGB-Stratified Phase II Trial J Thor Oncol 5 1382 1390 10.1097/JTO. 0b013e3181eba657
-
(2010)
J Thor Oncol
, vol.5
, pp. 1382-1390
-
-
Ready, N.1
Janne, P.2
Bogart, J.3
-
12
-
-
45149102984
-
Phase III trial of gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer. SWOG S0023
-
10.1200/JCO.2007.14.4824
-
K Kelly K Chansky LE Gaspar, et al. 2008 Phase III trial of gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer. SWOG S0023 J Clin Oncol 20 2450 2456 10.1200/JCO.2007.14.4824 The SWOG 0023 trial produced the extremely surprising result of demonstrating a significant detrimental effect for maintenance gefitinib after chemotherapy and concurrent radiation followed by consolidation docetaxel. Though still essentially unexplained, this finding underscores the importance of testing molecular markers in prospective clinical trials rather than presuming that favorable results in the setting of advanced NSCLC will definitely translate to other clinical settings.
-
(2008)
J Clin Oncol
, vol.20
, pp. 2450-2456
-
-
Kelly, K.1
Chansky, K.2
Gaspar, L.E.3
-
13
-
-
84861626518
-
Rubin M Efficacy of maintenance erlotinib versus placebo in patients with unresectable stage III non-small cell lung cancer (NSCLC) following concurrent chemoradiation (D0410, NCT00153803)
-
10.1097/JTO.0b013e31819846e4
-
J Rigas M Carey 2009 Rubin M Efficacy of maintenance erlotinib versus placebo in patients with unresectable stage III non-small cell lung cancer (NSCLC) following concurrent chemoradiation (D0410, NCT00153803) J Thor Oncol 4 S371 10.1097/JTO.0b013e31819846e4
-
(2009)
J Thor Oncol
, vol.4
, pp. 371
-
-
Rigas, J.1
Carey, M.2
-
14
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
19692680 10.1056/NEJMoa0810699 1:CAS:528:DC%2BD1MXhtVygsbfK
-
TS Mok Y-L Wu S Thongprasert, et al. 2009 Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma N Engl J Med 361 947 957 19692680 10.1056/NEJMoa0810699 1:CAS:528:DC%2BD1MXhtVygsbfK The IPASS trial by Mok and colleagues demonstrated that there are fundamental differences in outcomes with EGFR TKIs versus chemotherapy that are predicated overwhelmingly on molecular predictors rather than clinical variables. In fact, the clinical predictors of more favorable outcome with EGFR TKIs appear to be related to their correlation with molecular markers such as EGFR mutation, and those people with the same clinical and histologic features but an absence of an EGFR mutation were clearly better served by chemotherapy than an EGFR TKI as first-line therapy for advanced NSCLC.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.-L.2
Thongprasert, S.3
-
15
-
-
79951773393
-
Impact on disease-free survival of adjuvant erlotinib or gefitinib in pateints with resected lung adenocarcinomas that harbor EGFR mutations
-
10.1097/JTO.0b013e318202bffe
-
YY Janjigian BJ Park MF Zakowski, et al. 2011 Impact on disease-free survival of adjuvant erlotinib or gefitinib in pateints with resected lung adenocarcinomas that harbor EGFR mutations J Thor Oncol 6 569 575 10.1097/JTO.0b013e318202bffe
-
(2011)
J Thor Oncol
, vol.6
, pp. 569-575
-
-
Janjigian, Y.Y.1
Park, B.J.2
Zakowski, M.F.3
-
16
-
-
73949092851
-
A phase III randomized, double-blind, placebo-controlled trial of the epidermal growth factor receptor inhibitor gefitinib in completely resected stage IB-IIIA non-small cell lung cancer (NSCLC): NCIC CTG BR.19
-
10.1200/JCO.2009.22.9427
-
GD Goss I Lorimer MS Tsao, et al. 2010 A phase III randomized, double-blind, placebo-controlled trial of the epidermal growth factor receptor inhibitor gefitinib in completely resected stage IB-IIIA non-small cell lung cancer (NSCLC): NCIC CTG BR.19 J Clin Oncol 28 18s (LBA7005) 10.1200/JCO.2009.22.9427 Similar to the SWOG 0023 trial, the BR.19 study demonstrated very counterintuitive results of a strong suggestion of a detrimental effect for adjuvant gefitinib, and even more surprising was the observation that patients with an activating EGFR mutation had a trend toward an even more unfavorable result in terms of PFS and OS compared to recipients of placebo in this prematurely terminated trial.
-
(2010)
J Clin Oncol
, vol.28
-
-
Goss, G.D.1
Lorimer, I.2
Tsao, M.S.3
-
17
-
-
84855716260
-
-
accessed 3/22/11
-
http://www.clinicaltrials.gov/ct2/show/NCT00373425?term= RADIANT+erlotinib&rank=1, accessed 3/22/11.
-
-
-
-
18
-
-
84855716264
-
-
accessed 3/22/11
-
http://www.clinicaltrials.gov/ct2/show/NCT00567359?term= EGFR+mutation+sequist&rank=5, accessed 3/22/11.
-
-
-
-
19
-
-
84855716265
-
-
accessed 3/22/11
-
http://www.clinicaltrials.gov/ct2/show/NCT00775385?term= IFCT-0801&rank=1, accessed 3/22/11.
-
-
-
-
20
-
-
33748435058
-
DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
-
DOI 10.1056/NEJMoa060570
-
KA Olaussen A Dunant P Fouret, et al. 2006 DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy N Engl J Med 355 983 991 16957145 10.1056/NEJMoa060570 1:CAS:528:DC%2BD28XpsFKmtLw%3D (Pubitemid 44343542)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.10
, pp. 983-991
-
-
Olaussen, K.A.1
Dunant, A.2
Fouret, P.3
Brambilla, E.4
Andre, F.5
Haddad, V.6
Taranchon, E.7
Filipits, M.8
Pirker, R.9
Popper, H.H.10
Stahel, R.11
Sabatier, L.12
Pignon, J.-P.13
Tursz, T.14
Le Chevalier, T.15
Soria, J.-C.16
-
21
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open label randomized phase III trial
-
19410716 10.1016/S0140-6736(09)60569-9 1:CAS:528:DC%2BD1MXltlaqurs%3D
-
R Pirker JR Pereira A Szczesna, et al. 2009 Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open label randomized phase III trial Lancet 373 1525 1531 19410716 10.1016/S0140-6736(09) 60569-9 1:CAS:528:DC%2BD1MXltlaqurs%3D
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
-
22
-
-
70349723488
-
Phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small cell lung cancer: CALGB 30407
-
Govindan R, Bogart J, Wang X, et al. Phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small cell lung cancer: CALGB 30407. J Clin Oncol. 2009;27:A#7505.
-
(2009)
J Clin Oncol.
, vol.27
, pp. 7505
-
-
Govindan, R.1
Bogart, J.2
Wang, X.3
-
23
-
-
65349185779
-
A phase II study of cetuximab (C225) in combination with chemoradiation (CRT) in patients (PTS) with stage IIIA/B non-small cell lung cancer (NSCLC): A report of the 2 year and median survival (MS) for the RTOG 0324 trial
-
Blumenschein GR, Paulus R, Curran WJ, et al. A phase II study of cetuximab (C225) in combination with chemoradiation (CRT) in patients (PTS) with stage IIIA/B non-small cell lung cancer (NSCLC): a report of the 2 year and median survival (MS) for the RTOG 0324 trial. J Clin Oncol. 2008;26:A#7516.
-
(2008)
J Clin Oncol.
, vol.26
, pp. 7516
-
-
Blumenschein, G.R.1
Paulus, R.2
Curran, W.J.3
-
24
-
-
84855698009
-
-
accessed 3/22/11
-
http://www.clinicaltrials.gov/ct2/show/NCT00533949?term= RTOG+0617&rank=1, accessed 3/22/11.
-
-
-
-
25
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
DOI 10.1056/NEJMoa061884
-
A Sandler R Gray MC Perry, et al. 2006 Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N Engl J Med 355 2542 2550 17167137 10.1056/NEJMoa061884 1:CAS:528:DC%2BD28XhtlWqsbzI (Pubitemid 44917502)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
26
-
-
84855698010
-
-
accessed 3/22/11
-
http://www.clinicaltrials.gov/ct2/show/NCT00324805?term= ECOG+1505&rank=1, accessed 3/22/11.
-
-
-
-
27
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
DOI 10.1200/JCO.2004.11.022
-
DH Johnson L Fehrenbacher WF Novotny, et al. 2004 Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer J Clin Oncol 22 2184 2191 15169807 10.1200/JCO.2004.11.022 1:CAS:528:DC%2BD2cXpsVWltrg%3D (Pubitemid 41095154)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.11
, pp. 2184-2191
-
-
Johnson, D.H.1
Fehrenbacher, L.2
Novotny, W.F.3
Herbst, R.S.4
Nemunaitis, J.J.5
Jablons, D.M.6
Langer, C.J.7
DeVore III, R.F.8
Gaudreault, J.9
Damico, L.A.10
Holmgren, E.11
Kabbinavar, F.12
-
28
-
-
73949149605
-
Tracheoesophageal fistula formation in patients with lung cancer treated with chemoradiation and bevacizumab
-
19901100 10.1200/JCO.2009.24.7353 1:CAS:528:DC%2BC3cXhtF2ku7k%3D
-
DR Spigel JD Hainsworth DA Yardley, et al. 2010 Tracheoesophageal fistula formation in patients with lung cancer treated with chemoradiation and bevacizumab J Clin Oncol 28 43 48 19901100 10.1200/JCO.2009.24.7353 1:CAS:528:DC%2BC3cXhtF2ku7k%3D This report led to a highly publicized campaign to raise awareness of the potential danger of integrating bevacizumab into concurrent treatment with chest irradiation, as this practice appears to be associated with an unacceptably high risk of developing a tracheoesophageal fistula. Fortunately, this was detected based on its occurrence in several patients in a pair of prospective clinical trials and argues against combining targeted therapies with other treatment modalities outside of a clinical setting.
-
(2010)
J Clin Oncol
, vol.28
, pp. 43-48
-
-
Spigel, D.R.1
Hainsworth, J.D.2
Yardley, D.A.3
-
29
-
-
58149106091
-
Tracheo-esophageal fistula with bevacizumab after mediastinal radiation
-
10.1097/JTO.0b013e3181858eba
-
B Goodgame N Veeramachaneni A Patterson, et al. 2008 Tracheo-esophageal fistula with bevacizumab after mediastinal radiation J Thor Oncol 3 1080 1081 10.1097/JTO.0b013e3181858eba
-
(2008)
J Thor Oncol
, vol.3
, pp. 1080-1081
-
-
Goodgame, B.1
Veeramachaneni, N.2
Patterson, A.3
-
30
-
-
84855698518
-
-
accessed 3/22/11
-
http://www.clinicaltrials.gov/ct2/show/NCT00334815?term= swog+0533&rank=1, accessed 3/22/11.
-
-
-
-
31
-
-
33748644481
-
Multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of recombinant MAGE-A3 vaccine as adjuvant therapy in stage IB/II MAGE-A3-postiive, completely resected, non-small cell lung cancer (NSCLC)
-
Vansteenkiste J, Zielinski M, Dahabre J, et al. Multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of recombinant MAGE-A3 vaccine as adjuvant therapy in stage IB/II MAGE-A3-postiive, completely resected, non-small cell lung cancer (NSCLC). J Clin Oncol. 2006;24:A#7019.
-
(2006)
J Clin Oncol.
, vol.24
, pp. 7019
-
-
Vansteenkiste, J.1
Zielinski, M.2
Dahabre, J.3
-
32
-
-
84855716259
-
-
accessed 3/22/11
-
http://www.clinicaltrials.gov/ct2/show/NCT00480025?term=MAGRIT&rank= 1, accessed 3/22/11.
-
-
-
-
33
-
-
27244449289
-
Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
-
DOI 10.1200/JCO.2005.13.011
-
C Butts N Murray A Maksymuik, et al. 2005 Randomized phase IIB trial of BLP25 liposomal vaccine in stage IIIB and IV non-small cell lung cancer J Clin Oncol 23 6674 6681 16170175 10.1200/JCO.2005.13.011 1:CAS:528:DC%2BD2MXhtFWqsLbF (Pubitemid 46190262)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.27
, pp. 6674-6681
-
-
Butts, C.1
Murray, N.2
Maksymiuk, A.3
Goss, G.4
Marshall, E.5
Soulieres, D.6
Cormier, Y.7
Ellis, P.8
Price, A.9
Sawhney, R.10
Davis, M.11
Mansi, J.12
Smith, C.13
Vergidis, D.14
Ellis, P.15
MacNeil, M.16
Palmer, M.17
-
34
-
-
84855698515
-
-
accessed 3/22/11
-
http://www.clinicaltrials.gov/ct2/show/NCT01015443?term= stimuvax&rank=4, accessed 3/22/11.
-
-
-
|