Assessing the character of the rhBMP-2- and vancomycin-loaded calcium sulphate composites in vitro and in vivo

Archives of Orthopaedic and Trauma Surgery

Volumn 131, Issue 7, 2011, Pages 991-1001

  Wang, Yulu ^a   Wang, Xinqiang ^a   Li, Hang ^a   Xue, Deting ^a   Shi, Zhongli ^b   Qi, Yiying ^a   Ma, Qiang ^c   Pan, Zhijun ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Bone defect; Calcium sulphate; In vivo release; Osteomyelitis; rhBMP 2; Vancomycin

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CALCIUM SULFATE; GROWTH FACTOR; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE CONDUCTION; BONE DEFECT; BONE DEVELOPMENT; BONE GRAFT; BONE TISSUE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANALYSIS OF VARIANCE; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CALCIUM SULFATE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MALE; OSTEOMYELITIS; RABBITS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TIBIA; TISSUE AND ORGAN HARVESTING; VANCOMYCIN;

EID: 80051670012     PISSN: 09368051     EISSN: 14343916     Source Type: Journal    
DOI: 10.1007/s00402-011-1269-6     Document Type: Article

References (44)

1. Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM (2002) The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res 20(4):643-647. doi:10.1016/ S0736-0266(01)00133-4 (Pubitemid 34822981)
2. Kawanabe K, Okada Y, Matsusue Y, Iida H, Nakamura T (1998) Treatment of osteomyelitis with antibiotic-soaked porous glass ceramic. J Bone Joint Surg Br 80(3):527-530
3. Solberg BD, Gutow AP, Baumgaertner MR (1999) Efficacy of gentamycin-impregnated resorbable hydroxyapatite cement in treating osteomyelitis in a rat model. J Orthop Trauma 13(2):102-106
4. Korkusuz F, Korkusuz P, Eksioglu F, Gursel I, Hasirci V (2001) In vivo response to biodegradable controlled antibiotic release systems. J Biomed Mater Res 55(2):217-228. doi:10.1002/1097-4636(200105)55:2 (Pubitemid 32198504)
5. Shinto Y, Uchida A, Korkusuz F, Araki N, Ono K (1992) Cal-cium hydroxyapatite ceramic used as a delivery system for antibiotics. J Bone Joint Surg Br 74(4):600-604
6. Cornell CN, Tyndall D, Waller S, Lane JM, Brause BD (1993) Treatment of experimental osteomyelitis with antibiotic-impreg-nated bone graft substitute. J Orthop Res 11(5):619-626. doi: 10.1002/jor.1100110502 (Pubitemid 23320909)
7. Gazdag AR, Lane JM, Glaser D, Forster RA (1995) Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Surg 3(1):1-8
8. Giannoudis PV, Dinopoulos H, Tsiridis E (2005) Bone substitutes: an update. Injury 36(Suppl 3):S20-S27. doi:10.1016/j.injury. 2005.07.029
9. Mackey D, Varlet A, Debeaumont D (1982) Antibiotic loaded plaster of paris pellets: an in vitro study of a possible method of local antibiotic therapy in bone infection. Clin Orthop Relat Res 167:263-268 (Pubitemid 12090672)
10. Dacquet V, Varlet A, Tandogan RN, Tahon MM, Fournier L, Jehl F, Monteil H, Bascoulergue G (1992) Antibiotic-impreg-nated plaster of paris beads. Trials with teicoplanin. Clin Orthop Relat Res 282:241-249
11. Turner TM, Urban RM, Gitelis S, Kuo KN, Andersson GB (2001) Radiographic and histologic assessment of calcium sulfate in experimental animal models and clinical use as a resorbable bone-graft substitute, a bone-graft expander, and a method for local antibiotic delivery. One institution's experience. J Bone Joint Surg Am A 83(Suppl 2 (Pt 1)):8-18 (Pubitemid 33000535)
12. McKee MD, Wild LM, Schemitsch EH, Waddell JP (2002) The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results ofaprospective trial. J Orthop Trauma 16(9):622-627 (Pubitemid 35214851)
13. Kanellakopoulou K, Galanopoulos I, Soranoglou V, Tsaganos T, Tziortzioti V, Maris I, Papalois A, Giamarellou H, Giamarellos-Bourboulis EJ (2009) Treatment of experimental osteomyelitis caused by methicillin-resistant staphylococcus aureus with a synthetic carrier of calcium sulphate (stimulan) releasing moxi-floxacin. Int J Antimicrob Agents 33(4):354-359. doi:10.1016/j. ijantimicag.2008.09.008
14. Sanicola SM, Albert SF (2005) The in vitro elution characteristics of vancomycin and tobramycin from calcium sulfate beads. J Foot Ankle Surg 44(2):121-124. doi:10.1053/j.jfas.2005.01.006 (Pubitemid 40321545)
15. Hadjipavlou AG, Simmons JW, Yang J, Nicodemus CL, Esch O, Simmons DJ (2000) Plaster of paris as an osteoconductive material for interbody vertebral fusion in mature sheep. Spine (Phila Pa 1976) 25(1):10-15 (discussion 16)
16. Mirzayan R, Panossian V, Avedian R, Forrester DM, Menendez LR (2001) The use of calcium sulfate in the treatment ofbenign bone lesions. A preliminary report. J Bone Joint Surg Am A 83(3):355-358 (Pubitemid 32221564)
17. Sencan I, Sahin I, Tuzuner T, Ozdemir D, Yildirim M, Leblebi-cioglu H (2005) In vitro bacterial adherence to teicoplanin and calcium sulfate-soaked bone cement. J Chemother 17(2):174-178 (Pubitemid 40732876)
18. Englert C, Angele P, Fierlbeck J, Dendorfer S, Schubert T, Muller R, Lienhard S, Zellner J, Nerlich M, Neumann C (2007) Conductive bone substitute material with variable antibiotic delivery. Unfallchirurg 110(5):408-413. doi:10.1007/s00113-007-1229-3 (Pubitemid 46980453)
19. Wang X, You X, Huo S, Li X, Fan Y, Zhang Y, Zhang W (2007) Studies on the gs impregnated calcium sulfate implants. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 24(4):802-805
20. Orsini G, Ricci J, Scarano A, Pecora G, Petrone G, Iezzi G, Piattelli A (2004) Bone-defect healing with calcium-sulfate par-ticles and cement: An experimental study in rabbit J Biomed Mater Res B Appl Biomater 68(2):199-208. doi:10.1002/jbm. b.20012 (Pubitemid 38222240)
21. Lillo R, PeltierLF (1956) The substitution ofplaster of paris rods for portions of the diaphysis of the radius in dogs. Surg Forum 6:556-558
22. Cui X, Zhang B, Wang Y, Gao Y (2008) Effects of chitosan-coated pressed calcium sulfate pellet combined with recombinant human bone morphogenetic protein 2 on restoration of segmental bone defect. J Craniofac Surg 19(2):459-465. doi:10.1097/ SCS.0b013e31815ca034 (Pubitemid 351521686)
23. Turner TM, Urban RM, Hall DJ, Chye PC, Segreti J, Gitelis S (2005) Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop Relat Res 437:97-104 doi:00003086-200508000- 00017 (Pubitemid 41099073)
24. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143-147 (Pubitemid 29282067)
25. Yoshimura H, Muneta T, Nimura A, Yokoyama A, Koga H, Sekiya I (2007) Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tis-sue, and muscle. Cell Tissue Res 327(3):449-462. doi:10.1007/ s00441-006-0308-z (Pubitemid 46232315)
26. Makinen TJ, Veiranto M, Knuuti J, Jalava J, Tormala P, Aro HT (2005) Efficacy of bioabsorbable antibiotic containing bone screw in the prevention of biomaterial-related infection due to staphylococcus aureus. Bone 36(2):292-299. doi:10.1016/j.bone. 2004.11.009 (Pubitemid 40283586)
27. Kassis I, Zangi L, Rivkin R, Levdansky L, Samuel S, Marx G, Gorodetsky R (2006) Isolation of mesenchymal stem cells from g-csf-mobilized human peripheral blood using fibrin microbeads. Bone Marrow Transpl 37(10):967-976. doi:10.1038/sj.bmt.170 5358 (Pubitemid 43792558)
28. Beardmore AA, Brooks DE, Wenke JC, Thomas DB (2005) Effectiveness of local antibiotic delivery with an osteoinductive and osteoconductive bone-graft substitute. J Bone Joint Surg Am 87(1):107-112. doi:10.2106/JBJS.C.01670 (Pubitemid 40094145)
29. Mader JT, Shirtliff ME, Bergquist SC, Calhoun J (1999) Anti-microbial treatment of chronic osteomyelitis. Clin Orthop Relat Res 360:47-65
30. Neut D, van de Belt H, Stokroos I, van Horn JR, van der Mei HC, Busscher HJ (2001) Biomaterial-associated infection of genta-micin-loaded pmma beads in orthopaedic revision surgery. J Antimicrob Chemother 47(6):885-891 (Pubitemid 32519840)
31. Peltier LF (2001) The use ofplaster of paris to fill large defects in bone: a preliminary report. 1959. Clin Orthop Relat Res 382:3-5
32. Shaffer CD, App GR (1971) The use ofplaster of paris in treating infrabony periodontal defects in humans. J Periodontol 42(11):685-690
33. Furlaneto FA, Nagata MJ, Fucini SE, Deliberador TM, Okamoto T, Messora MR (2007) Bone healing in critical-size defects treated with bioactive glass/calcium sulfate: A histologic and histometric study in rat calvaria. Clin Oral Implants Res 18(3):311-318. doi:10.1111/j.1600-0501.2006.01331.x
34. Gao C, Huo S,LiX, You X, Zhang Y, Gao J (2007) Charac-teristics of calcium sulfate/gelatin composite biomaterials for bone repair. J Biomater Sci Polym Ed 18(7):799-824. doi: 10.1163/156856207781367710 (Pubitemid 47184913)
35. Bodde EW, Boerman OC, Russel FG, Mikos AG, Spauwen PH, Jansen JA (2008) The kinetic and biological activity of different loaded rhbmp-2 calcium phosphate cement implants in rats. J Biomed Mater Res A 87(3):780-791. doi:10.1002/jbm.a.31830
36. Ruhe PQ, Boerman OC, Russel FG, Spauwen PH, Mikos AG, Jansen JA (2005) Controlled release of rhbmp-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo. J Control Release 106(1-2):162-171. doi:10.1016/j.jconrel. 2005.04.018 (Pubitemid 41140091)
37. Warren SM, Nacamuli RK, Song HM, Longaker MT (2004) Tissue-engineered bone using mesenchymal stem cells and a biodegradable scaffold. J Craniofac Surg 15(1):34-37
38. Herron S, Thordarson DB, Winet H, Luk A, Bao JY (2003) Ingrowth of bone into absorbable bone cement: an in vivo microscopic evaluation. Am J Orthop (Belle Mead NJ) 32(12):581-584
39. Tamimi FM, Torres J, Tresguerres I, Clemente C, Lopez-Cabarcos E, Blanco LJ (2006) Bone augmentation in rabbit calvariae: com-parative study between bio-oss and a novel beta-tcp/dcpd granulate. J Clin Periodontol 33(12):922-928. doi:10.1111/j.1600-051X. 2006.01004.x (Pubitemid 44715431)
40. Cunningham NS, Paralkar V, Reddi AH (1992) Osteogenin and recombinant bone morphogenetic protein 2b are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mrna expression. Proc Natl Acad Sci USA 89(24):11740-11744 (Pubitemid 23004719)
41. Uludag H, Gao T, Porter TJ, Friess W, Wozney JM (2001) Delivery systems for bmps: factors contributing to protein retention at an application site. J Bone Joint Surg Am A 83(Suppl 1 (Pt 2)):S128-S135
42. Chen X, Schmidt AH, Mahjouri S, Polly DW Jr, Lew WD (2007) Union of a chronically infected internally stabilized segmental defect in the rat femur after debridement and application of rhbmp-2 and systemic antibiotic. J Orthop Trauma 21(10):693-700. doi:10.1097/BOT.0b013e31815a7e91 (Pubitemid 350073453)
43. Edin ML, Miclau T, Lester GE, Lindsey RW, Dahners LE (1996) Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop Relat Res 333:245-251 (Pubitemid 26428036)
44. Haleem AA, Rouse MS, Lewallen DG, Hanssen AD, Steckelberg JM, Patel R (2004) Gentamicin and vancomycin do not impair experimental fracture healing. Clin Orthop Relat Res 427:22-24 (Pubitemid 39362825)