The effect of SYT-SSX and extracellular signal-regulated kinase (ERK) on cell proliferation in Synovial sarcoma

Pathology and Oncology Research

Volumn 17, Issue 2, 2011, Pages 357-367

  Cai, Wenjuan ^a,b   Sun, Yan ^a   Wang, Wei ^a,b   Han, Chunrong ^a   Ouchida, Mamoru ^c   Xia, Wenbin ^a   Zhao, Xiulan ^a   Sun, Baocun ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TIANJIN FIRST CENTRAL HOSPITAL   (China)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cell proliferation; Fusion gene; Synovial sarcoma

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; LIPOFECTAMINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; FUSION GENE; GENE EXPRESSION; GENE SEQUENCE; GENETIC REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; SSX GENE; SYNOVIAL SARCOMA; SYT GENE;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; ONCOGENE PROTEINS, FUSION; RNA INTERFERENCE; SARCOMA, SYNOVIAL; SIGNAL TRANSDUCTION; TISSUE ARRAY ANALYSIS;

EID: 80051668580     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-010-9334-y     Document Type: Article

References (26)

1. Lewis JJ, Antonescu CR, Leung DH et al (2000) Synovial sarcoma: a multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity. J Clin Oncol 18(10):2087-2094 (Pubitemid 30324362)
2. Clark J, Rocques PJ, Crew AJ et al (1994) Identification of novel genes, SYT and SSX, involved in the t (X;18) (p11.2;q11.2) translocation found in human synovial sarcoma. Nat Genet 7(4):502-508 (Pubitemid 24308337)
3. dos Santos NR, de Bruijn DR, van Kessel AG (2001) Molecular mechanisms underlying human synovial sarcoma development. Genes Chromosom Cancer 30(1):1-14
4. Ladanyi M (2001) Fusions of the SYT and SSX genes in synovial sarcoma. Oncogene 20(40):5755-5762 (Pubitemid 32928113)
5. Nagai M, Tanaka S, Tsuda M et al (2001) Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha. Proc Natl Acad Sci USA 98(7):3843-3848 (Pubitemid 32249859)
6. Nilsson G, Skytting B, Xie Y et al (1999) The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. Cancer Res 59(13):3180-3184 (Pubitemid 29316020)
7. Inagaki H, Nagasaka T, Otsuka T, Sugiura E, Nakashima N, Eimoto T (2000) Association of SYT-SSX fusion types with proliferative activity and prognosis in synovial sarcoma. Mod Pathol 13(5):482-488 (Pubitemid 30332098)
8. Xie Y, Skytting B, Nilsson G et al (2002) The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t (X;18) (p11.2; q11.2) and the cell cycle machinery. Oncogene 21(37):5791-5796 (Pubitemid 35333013)
9. Xie Y, Tornkvist M, Aalto Y et al (2003) Gene expression profile by blocking the SYT-SSX fusion gene in synovial sarcoma cells. Identification of XRCC4 as a putative SYT-SSX target gene. Oncogene 22(48):7628-7631 (Pubitemid 37464096)
10. Kawai A, Naito N, Yoshida A et al (2004) Establishment and characterization of a biphasic synovial sarcoma cell line, SYO-1. Cancer Lett 204(1):105-113 (Pubitemid 38117199)
11. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods 25 (4):402-408 (Pubitemid 34164012)
12. Siami K, McCluggage WG, Ordonez NG et al (2007) Thyroid transcription factor-1 expression in endometrial and endocervical adenocarcinomas. Am J Surg Pathol 31(11):1759-1763 (Pubitemid 350287575)
13. Remmele W, Schicketanz KH (1993) Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer. Computer-assisted image analysis (QIC score) vs. subjective grading (IRS). Pathol Res Pract 189(8):862-866 (Pubitemid 23308006)
14. Xie Y, Skytting B, Nilsson G et al (2002) SYT-SSX is critical for cyclin D1 expression in synovial sarcoma cells: a gain of function of the t (X;18) (p11.2;q11.2) translocation. Cancer Res 62(13):3861-3867 (Pubitemid 34728873)
15. Ramos JW (2008) The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int J Biochem Cell Biol 40(12):2707-2719
16. Yu Q, Geng Y, Sicinski P (2001) Specific protection against breast cancers by cyclin D1 ablation. Nature 411(6841):1017-1021 (Pubitemid 32612319)
17. Bose S, Chandran S, Mirocha JM, Bose N (2006) The Akt pathway in human breast cancer: a tissue-array-based analysis. Mod Pathol 19(2):238-245 (Pubitemid 43117608)
18. Hsu MK, Qiao L, Ho V et al (2006) Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats. J Hepatol 44(2):375-382 (Pubitemid 43069220)
19. Ramdass B, Maliekal TT, Lakshmi S et al (2007) Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression. Gynecol Oncol 104(2):352-361 (Pubitemid 46135657)
20. Liu Y, Xi L, Liao G et al (2007) Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2. BMC Cancer 7:22
21. Watanabe M, Miyajima N, Igarashi M, Endo Y, Watanabe N, Sugano S (2008) Sodium phenylacetate inhibits the Ras/MAPK signaling pathway to induce reduction of the c-Raf-1 protein in human and canine breast cancer cells. Breast Cancer Res Treat
22. Recchia AG, Musti AM, Lanzino M et al (2009) A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK-dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells. Int J Biochem Cell Biol 41(3):603-614
23. Bockstaele L, Coulonval K, Kooken H, Paternot S, Roger PP (2006) Regulation of CDK4. Cell Div 1:25
24. Lobenhofer EK, Huper G, Iglehart JD, Marks JR (2000) Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. Cell Growth Differ 11(2):99-110 (Pubitemid 30131490)
25. Squires MS, Nixon PM, Cook SJ (2002) Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1. Biochem J 366(Pt 2):673-680 (Pubitemid 35001712)
26. Motti ML, De Marco C, Califano D et al (2007) Loss of p27 expression through RAS->BRAF->MAP kinase-dependent pathway in human thyroid carcinomas. Cell cycle 6(22):2817-2825 (Pubitemid 350277175)