Discriminant functions in distinguishing beta thalassemia trait and iron deficiency anemia: The value of the RDW-SD

Internet Journal of Hematology

Volumn 7, Issue 2, 2011, Pages

  Trivedi Dhara, P ^a   Shah Harsh, A ^a  

^a M P SHAH MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A2;

ADULT; ARTICLE; BETA THALASSEMIA; BLOOD CELL; CELLULAR DISTRIBUTION; CLINICAL LABORATORY; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISCRIMINANT ANALYSIS; ERYTHROCYTE COUNT; FEMALE; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY ANEMIA; IRON THERAPY; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; RED BLOOD CELL DISTRIBUTION; SENSITIVITY AND SPECIFICITY;

EID: 80051642985     PISSN: None     EISSN: 15402649     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Wharton BA. Iron deficiency in children: detection and prevention. Br J Haematol 1999;106:270-280.
2. Lukens JN. The thalassemias and related disorders: an overview. In: Lee GR, et al., editors. Wintrobe's Clinical Hematology. 10th ed. Giza: Mass Publishing, 1999: 405-33.
3. Harmening DM. Clinical Hematology and Fundamentals of Hemostasis 4th edn (F.A. Davis Company, Philadelphia) pp. 2002;104-87.
4. El-Agouza I, Abu Shahla A, Sirdash M. The effect of iron deficiency anemia on the levels of hemoglobin subtypes: possible consequences for clinical diagnosis. Clin Lab Haem 2002;24:285-9.
5. Massey AC. Microcytic anemia. Differential diagnosis and management of iron deficiency anemia. Med Clin North Am 1992;73:549-66.
6. Raper AB. Differentiation of iron-deficiency anaemia from thalassaemia trait. Lancet 1973;1:778.
7. Novak RW. Red blood cell distribution width in pediatric microcytic anemias. Pediatrics 1987;80:251-4.
8. Junca J, Flores A, Roy C, et al. Red cell distribution width, free erythrocyte protoporphyrin, and England-Fraser index in the differential diagnosis of microcytosis due to iron deficiency or beta-thalassemia trait. A study of 200 cases of microcytic anemia. Hematol Pathol 1991;5:33-6.
9. Olivieri NF. The beta - thalassemias. N Engl J Med. 1999;341:99-109.
10. Oski FA. Iron deficiency in infancy and childhood. N Engl J Med 1993;329: 190-3.
11. Suad MA, Al-Anwar MA, Doa'a A. Validity assessment of nine discriminant functions used for the differentiation between iron deficiency anemia and thalassemia minor. J Trop Pediatr 2007;53:93-7.
12. Beyan C, Kaptan K, Ifran A. Predictive value of discriminant functions in differential diagnosis of iron deficiency anemia and beta-thalassemia trait. Eur J Haematol 2007;78:524-6.
13. Pekkanen J and Pearce N. (1999) Defining asthma in epidemiological studies. Eur Respir J 14:951-7.
14. Walters JG and RF Garrity RDW-SD and RDW-CV: Their relationship to RBC distribution curves and anisocytosis. Sysmex Journal International 1993; 3(1);40-45
15. Clarke G and Higgins T. Laboratory investigation of hemoglobinopathies and thalassemia: review and update. Clin Chem 2000;46:1284-90.
16. Yermiahu T, Ben-Shalom M, Porath A, et al. Quantitative determinations of microcytic-hypochromic red blood cell population and glycerol permeability in iron-deficiency anemia and BTTassemia minor. Ann Hematol 1999;78:468-71.
17. Roberts GT and El-Badawi SB. (1987) Red cell distribution widths index in some hematologic diseases. Am J Clin Pathol 83:222-6.
18. Marsh WL Jr, Bishop JW, Darcy TP. (1987) Evaluation of red cell volume distribution width (RDW). Hematol Pathol 1:117-23.
19. Flynn MM, Reppun TS, Bhagavan NV. (1986) Limitations of red blood cell distribution width (RDW) in evaluation of microcytosis. Am J Clin Pathol 85:445-9.
20. Burk M, Arenz J, Giagounidis AA, et al. (1995) Erythrocyte functions as screening tests for the differentiation of microcytic anemias. Eur J Med Res 1:33-7.
21. Mentzer WC. Differentiation of iron deficiency from thalassemia trait. Lancet 1973;1:882-4.
22. Shine I and Lal S. A strategy to detect beta-thalassemia minor. Lancet 1977;1:692-4.
23. England JM and Fraser P. Discriminant between iron-deficiency and heterozygous thalassemia syndromes in differential diagnosis of microcytosis. Lancet 1979;1:145-8.
24. Green R and King R. A new red blood cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. Blood cells 1989;15:481-95.
25. Jayabose S, Giavanelli J, Levendoglu-Tugal O, et al. Differentiating iron deficiency anemia from thalassemia minor by using RDW-based index. J Pediatr Hematol 1999;21:314.
26. Srivastava PC and Bevington JM. Iron deficiency and-or thalassemia trait. Lancet 1973;1:832-5.
27. Ricerca BM, Storti S, d'Onofrio G, et al. Differentiation of iron deficiency from thalassemia trait: a new approach. Haematologica 1987;75:409-13.