Does metoclopramide impair anastomotic healing of the left colon of rats?;A metoclopramida prejudica a cicatrização de anastomoses do cólon esquerdo de ratos?

Acta Cirurgica Brasileira

Volumn 26, Issue 4, 2011, Pages 297-302

  e Silva, Silvana Marques ^a   Ferreira, Vânia Maria Moraes ^a   Feres, Omar ^b   de Oliveira, Paulo Gonçalves ^a   de Sousa, João Batista ^a  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anastomosis; Colon; Gastrointestinal motility; Metoclopramide; Rats; Surgical; Tissue adhesions

Indexed keywords

HYDROXYPROLINE; METOCLOPRAMIDE;

ANASTOMOSIS DEHISCENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON ANASTOMOSIS; CONTROLLED STUDY; END TO END ANASTOMOSIS; GASTROINTESTINAL MOTILITY; HEALING IMPAIRMENT; MALE; NONHUMAN; RAT;

ANASTOMOSIS, SURGICAL; ANIMALS; COLON; DOPAMINE ANTAGONISTS; GASTROINTESTINAL MOTILITY; HYDROXYPROLINE; MALE; METOCLOPRAMIDE; POSTOPERATIVE PERIOD; RANDOM ALLOCATION; RATS; RATS, WISTAR; TENSILE STRENGTH; TIME FACTORS; TISSUE ADHESIONS; WOUND HEALING;

EID: 80051616730     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502011000400009     Document Type: Article

References (20)

1. Uzun MA, Koksal N, Ozkan OF, Kayahan M, Gumrukcu G. Salvage repair of anastomotic dehiscence following colon surgery using an expanded polytetrafluoroethylene graft. Tech Coloproctol. 2010 Aug 6 [Epub ahead of print].
2. Eberl T, Jagoditsch M, Klingler A, Tschmelitsch J. Risk factors for anastomotic leakage after resection for rectal cancer. Am J Surg. 2008;196(4):592-8.
3. Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 2001;18(4):260-73.
4. Garcia-Olmo D, Lucas FJ, Paya J. Relationship between peritoneal adhesion phenomena and the experimental resistance of colonic anastomoses: influence of omentoplasty. Eur Surg Res. 1996;28(4):315-22.
5. Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum. 2003;46(10):1310-9.
6. Springall RG, Spitz L. Prevention of post-operative adhesions using a gastrointestinal prokinetic agent. J Pediatr Surg. 1989;24(6):530-3.
7. Tonini M, Cipollina L, Poluzzi E, Crema F, Corazza GR, De Ponti F. Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther. 2004;19(4):379-90.
8. Garcia-Olmo D, Paya J, Lucas FJ, Garcia-Olmo DC. The effects of the pharmacological manipulation of postoperative intestinal motility on colonic anastomoses. An experimental study in a rat model. Int J Colorectal Dis. 1997;12(2):73-7.
9. Nair SK, Bhat IK, Aurora AL. Role of proteolytic enzyme in the prevention of postoperative intraperitoneal adhesions. Arch Surg. 1974;108(6):849-53.
10. Stegemann H, Stalder K. Determination of hydroxyproline. Clin Chim Acta. 1967;18:267-73.
11. Medugorac I. Collagen content in different areas of normal and hypertrophied rat myocardium. Cardiovasc Res. 1980;14(9):551-4.
12. Oksuz H, Zencirci B, Ezberci M. Comparison of the effectiveness of metoclopramide, ondansetron, and granisetron on the prevention of nausea and vomiting after laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A. 2007;17(6):803-8.
13. Tonini M. Recent advances in the pharmacology of gastrointestinal prokinetics. Pharmacol Res. 1996;33(4-5):217-26.
14. Zizzo MG, Mule F, Mastropaolo M, Serio R. D1 receptors play a major role in the dopamine modulation of mouse ileum contractility. Pharmacol Res. 2010;61(5):371-8.
15. Sparnon AL, Spitz L. Pharmacological manipulation of postoperative intestinal adhesions. Aust N Z J Surg. 1989;59(9):725-9.
16. Haciyanli M, Fuzun M, Unek T, Tokgoz Z. Does the administration route of leucovorin have any influence on the impairment of colonic healing caused by intraperitoneal 5-fluorouracil treatment? Eur Surg Res. 2001;33(2):80-5.
17. Sousa JB, Soares EG, Aprilli F. Effects of diclofenac sodium on intestinal anastomotic healing. Experimental study on the small intestine of rabbits. Dis Colon Rectum. 1991;34(7)613-7.
18. Oliveira PG, Soares EG, Aprilli F. Influence of misoprostol, a synthetic prostaglandin E1 analog, on the healing of colonic anastomoses in rats. Dis Colon Rectum. 1994;37(7)660-3.
19. Agalar F, Hamaloglu E, Daphan C, Tarim A, Onur R, Renda N, Sayek I. Effects of CO2 insufflation and laparotomy on wound healing in mice. Aust N Z J Surg. 2000;70(10):739-42.
20. Karataş A, Kocael A, Aytaç E, Gökcal F, Salihoǧlu Z, Uzun H, Paksoy M. Amelogenin (an extracellular matrix protein) application on ischemic colon anastomosis in rats. Ulus Travma Acil Cerrahi Derg. 2010;16(6):487-90.