QSAR study of C allosteric binding site of HCV NS5B polymerase inhibitors by support vector machine

Molecular Diversity

Volumn 15, Issue 3, 2011, Pages 645-653

  Pourbasheer, Eslam ^a   Riahi, Siavash ^a   Ganjali, Mohammad Reza ^a   Norouzi, Parviz ^a  

^a UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Chemometrics; Genetic algorithms; Hepatitis C virus (HCV); Multiple linear regressions; QSAR; Support vector machine

Indexed keywords

2 ME PIPERIDINE; 2 ME PYRROLIDINE; HEPATITIS C VIRUS POLYMERASE INHIBITOR; MORPHOLINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PIPERIDINE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG STRUCTURE; GENETIC ALGORITHM; IC 50; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ALLOSTERIC SITE; ANTIVIRAL AGENTS; DRUG DESIGN; ENZYME INHIBITORS; HEPACIVIRUS; LINEAR MODELS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT VECTOR MACHINES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 80051594196     PISSN: 13811991     EISSN: 1573501X     Source Type: Journal    
DOI: 10.1007/s11030-010-9283-0     Document Type: Article

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