Computed high concentrations of low-density lipoprotein correlate with plaque locations in human coronary arteries

Journal of Biomechanics

Volumn 44, Issue 13, 2011, Pages 2466-2471

  Olgac, Ufuk ^a,d   Knight, Joseph ^a   Poulikakos, Dimos ^a   Saur, Stefan C ^a   Alkadhi, Hatem ^b   Desbiolles, Lotus M ^b   Cattin, Philippe C ^c   Kurtcuoglu, Vartan ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d KOÇ UNIVERSITY   (Turkey)

Author keywords

Atherosclerosis; Computational fluid dynamics; Computed tomography; LDL transport; Patient specific simulations

Indexed keywords

ATHEROSCLEROSIS; COMPUTATIONAL FLUID; COMPUTED TOMOGRAPHY; LDL TRANSPORT; PATIENT-SPECIFIC SIMULATIONS;

BLOOD VESSELS; COMPUTATIONAL FLUID DYNAMICS; COMPUTERIZED TOMOGRAPHY; CONCENTRATION (PROCESS); DISEASES; LIFE CYCLE; TOMOGRAPHY;

HEART;

LOW DENSITY LIPOPROTEIN;

ACCURACY; ADULT; AGED; ARTERY DIAMETER; ARTICLE; ATHEROGENESIS; BIOMECHANICS; BLOOD FLOW VELOCITY; COMPUTATIONAL FLUID DYNAMICS; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER MODEL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; FEMALE; HUMAN; LEFT CORONARY ARTERY; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RIGHT CORONARY ARTERY; SHEAR STRESS; TISSUE DISTRIBUTION;

COMPUTER SIMULATION; CORONARY VESSELS; ENDOTHELIUM; HUMANS; LIPOPROTEINS, HDL; PLAQUE, ATHEROSCLEROTIC;

EID: 80051564676     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2011.06.022     Document Type: Article

References (20)

1. Alkadhi H., Scheffel H., Desbiolles L., Gaemperli O., Stolzmann P., Plass A., Goerres G.W., Luescher T.F., Genoni M., Marincek B., et al. Dual-source computed tomography coronary angiography: influence of obesity, calcium load, and heart rate on diagnostic accuracy. Eur. Heart J. 2008, 29(6):766-776.
2. Austen W.G., Edwards J.E., Frye R.L., Gensini G.G., Gott V.L., Griffith L.S., McGoon D.C., Murphy M.L., Roe B.B. A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc committee for grading of coronary artery disease, council on cardiovascular surgery. Am. Heart Assoc. Circ. 1975, 51(Suppl. 4):5-40.
3. Berne R.M., Levy M.N. Cardiovascular Physiology 1986, Mosby, St. Louis. 5th ed.
4. Bock, S., Kuhnel, C., Boskamp, T., Peitgen, H.O., 2008. Robust vessel segmentation-art. no. 691539. In: Giger, M.L.K.N. (Ed.), Proceedings of the Medical Imaging 2008 Conference, pp. 91539-91539.
5. Cancel L.M., Fitting A., Tarbell J.M. In vitro study of LDL transport under pressurized (convective) conditions. Am. J. Physiol. Heart Circ. Physiol. 2007, 293(1):H126-H132.
6. Cheng C., Helderman F., Tempel D., Segers D., Hierck B., Poelmann R., van Tol A., Duncker D.J., Robbers-Visser D., Ursem N.T., et al. Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis 2007, 195(2):225-235.
7. Goldstein J.L., Brown M.S. The low-density lipoprotein pathway and its relation to atherosclerosis. Annu. Rev. Biochem. 1977, 46:897-930.
8. Knight J., Olgac U., Saur S.C., Poulikakos D., Marshall W., Cattin P.C., Alkadhi H., Kurtcuoglu V. Choosing the optimal wall shear parameter for the prediction of plaque location-a patient-specific computational study in human right coronary arteries. Atherosclerosis 2010, 211(2):445-450.
9. Lusis A.J. Atherosclerosis. Nature 2000, 407(6801):233-241.
10. Milnor W.R. Hemodynamics. 1989, Williams & Wilkins, Baltimore, (419 p.). 2nd ed.
11. Nakashima Y., Fujii H., Sumiyoshi S., Wight T.N., Sueishi K. Early human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration. Arterioscler. Thromb. Vasc. Biol. 2007, 27(5):1159-1165.
12. Olgac U., Kurtcuoglu V., Poulikakos D. Computational modeling of coupled blood-wall mass transport of LDL: effects of local wall shear stress. Am. J. Physiol. Heart Circ. Physiol. 2008, 294(2):H909-H919.
13. Olgac U., Poulikakos D., Saur S.C., Alkadhi H., Kurtcuoglu V. Patient-specific three-dimensional simulation of LDL accumulation in a human left coronary artery in its healthy and atherosclerotic states. Am. J. Physiol. Heart Circ. Physiol. 2009, 296(6):H1969-H1982.
14. Saur S.C., Alkadhi H., Desbiolles L., Szekely G., Cattin P.C. Automatic detection of calcified coronary plaques in computed tomography data sets. Med. Image Comput. Comput. Assist. Interv. Int. Conf. Med. Image Comput. Comput. Assist. Interv. 2008, 11(Part 1):170-177.
15. Saur S.C., Alkadhi H., Stolzmann P., Baumuller S., Leschka S., Scheffel H., Desbiolles L., Fuchs T.J., Szekely G., Cattin P.C. Effect of reader experience on variability, evaluation time and accuracy of coronary plaque detection with computed tomography coronary angiography. Eur. Radiol. 2010, 20(7):1599-1606.
16. Schwenke D.C., Carew T.E. Initiation of atherosclerotic lesions in cholesterol-fed rabbits. 1. Focal increases in arterial LDL concentration precede development of fatty streak lesions. Arteriosclerosis 1989, 9(6):895-907.
17. Skalen K., Gustafsson M., Rydberg E.K., Hulten L.M., Wiklund O., Innerarity T.L., Boren J. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature 2002, 417(6890):750-754.
18. Smedby O. Do plaques grow upstream or downstream? An angiographic study in the femoral artery. Arterioscler. Thromb. Vasc. Biol. 1997, 17(5):912-918.
19. Soulis J.V., Giannoglou G.D., Papaioannou V., Parcharidis G.E., Louridas G.E. Low-density lipoprotein concentration in the normal left coronary artery tree. Biomed. Eng. Online 2008, 7:26.
20. Tompkins R.G., Yarmush M.L., Schnitzer J.J., Colton C.K., Smith K.A., Stemerman M.B. Low-density lipoprotein transport in blood-vessel walls of squirrel-monkeys. Am. J. Physiol. 1989, 257(2):H452-H464.