Antitumor efficacy and amelioration of oxidative stress by Trichosanthes dioica root against Ehrlich ascites carcinoma in mice

Pharmaceutical Biology

Volumn 49, Issue 9, 2011, Pages 927-935

  Bhattacharya, Sanjib ^a   Prasanna, Angelene ^b   Majumdar, Piyali ^b   Kumar, R B Suresh ^b   Haldar, Pallab K ^b  

^a Bengal School of Technology   (India)

^b JADAVPUR UNIVERSITY   (India)

Author keywords

Antioxidant; glutathione; glutathione S transferase; lipid peroxidation

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; CATALASE; FLUOROURACIL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEMOGLOBIN; MALONALDEHYDE; PLANT EXTRACT; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRICHOSANTHES DIOICA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SCREENING; EHRLICH ASCITES TUMOR; ENZYME ACTIVITY; ERYTHROCYTE COUNT; HEMATOCRIT; LEUKOCYTE COUNT; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PLANT ROOT; SURVIVAL TIME; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ASCITES; BODY WEIGHT; CARCINOMA, EHRLICH TUMOR; CELL COUNT; CELL SURVIVAL; DRUG ADMINISTRATION SCHEDULE; GLUTATHIONE; HEMATOLOGIC TESTS; INDIA; MALE; MALONDIALDEHYDE; MICE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; SUPEROXIDE DISMUTASE; TRICHOSANTHES; TUMOR BURDEN;

CUCURBITACEAE; MUS; TRICHOSANTHES DIOICA;

EID: 80051515065     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.557080     Document Type: Article

References (66)

1. Aebi H. (1974). Catalase. In: Packer L, ed. Methods in Enzymatic Analysis. Vol. II. New York: Academic Press, pp. 673-684.
2. Andreani A, Scapini G, Galatulas I, Bossa R. (1983). Potential antitumor agents IX: Synthesis and antitumor activity of two analogues of ketocaine. J Pharm Sci, 72, 814-815. (Pubitemid 13076413)
3. Anonymous. (1976). The Wealth of India: Raw Materials. New Delhi: Publication and Information Directorate, CSIR.
4. Anonymous. (2008). OECD Guidelines for the Testing of Chemicals/ Section 4: Health Effects Test No. 425: Acute Oral Toxicity: Up-and- Down Procedure. Paris: OECD Publishing.
5. Arias IM, Jakoby WB. (1976). Glutathione: Metabolisms and Functions. New York: Raven Press.
6. Balasubramaniyan N, Subramanian S, Govindasamy S. (1994). Status of antioxidant systems in human carcinoma of uterine cervix. Cancer Lett, 87, 187-192.
7. Baumgartner WA, Hill VA, Wright ET. (1978). Antioxidant effects in the development of Ehrlich ascites carcinoma. Am J Clin Nutr, 31, 457-465. (Pubitemid 8300940)
8. Bhattacharya S, Haldar PK, Ghosh AK. (2009). In vitro effects of Trichosanthes dioica leaves on annelids and nematodes. Pharmacologyonline, 5, 242-248.
9. Bhattacharya S, Haldar PK, Ghosh AK. (2010). Paralytic and lethal effects of Trichosanthes dioica root extracts in experimental worms. Pharm Biol, 48, 960-965.
10. Bhattacharya S, Haldar PK. (2010a). Antibacterial activity of Trichosanthes dioica root. Global J Pharmacol, 4, 122-126. Bhattacharya S, Haldar PK. (2010b). Evaluation of in vitro cytotoxic effect of Trichosanthes dioica root. Phcog Res, 2, 355-358.
11. Casado A, de la Torre R, López-Fernández ME, Carrascosa D, Casado MC, Ramírez MV. (1995). Superoxide dismutase and catalase blood levels in patients with malignant diseases. Cancer Lett, 93, 187-192.
12. Chen L, Watkins JF. (1970). Evidence against the presence of H2 histocompatibility antigens in Ehrlich ascites tumour cells. Nature, 225, 734-735
13. Coursin DB, Cihla HP, Sempf J, Oberley TD, Oberley LW. (1996). An immunohistochemical analysis of antioxidant and glutathione S-transferase enzyme levels in normal and neoplastic human lung. Histol Histopathol, 11, 851-860. (Pubitemid 26364206)
14. Clarkson D, Burchneal JH. (1965). Preliminary screening of antineoplastic drugs. Prog Clin Cancer, 1, 625-629.
15. Dacie JV, Lewis SM. (1958). Practical Hematology. 2nd Ed. London: J & A, Churchill Ltd.
16. D'Armour FE, Blood FR, Belden DA. (1965). The Manual for Laboratory Works in Mammalian Physiology. Illinois, Chicago: The University of Chicago Press.
17. da Rocha AB, Lopes RM, Schwartsmann G. (2001). Natural products in anticancer therapy. Curr Opin Pharmacol, 1, 364-369. (Pubitemid 33585985)
18. Devi KN, Reddy CC, Raveendra A, Thyagaraju K. (2002). Effect of ß-methylcholanthrene on glutathione S-transferases of rat testis. Curr Sci, 82, 1282-1287. (Pubitemid 135694178)
19. Ellman GL. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys, 82, 70-77.
20. Evans WC. (2002). Trease and Evans Pharmacognosy. New Delhi: Reed Elsevier India Pvt. Ltd.
21. Fastaia J, Dumont A. (1976). Pathogenesis of ascitis in mice with peritoneal carcinomatosis. J Nat Cancer Inst, 56, 547-549.
22. Ghaisas MM, Tanwar MB, Ninave PB, Navghare VV, Takawale AR, Zope VS, Deshpande AD. (2008). Hepatoprotective activity of aqueous and ethanolic extract of Trichosanthes dioica Roxb. in ferrous sulphate-induced liver injury. Pharmacologyonline, 4, 127-135.
23. Gmünder H, Dröge W. (1991). Differential effects of glutathione depletion on T cell subsets. Cell Immunol, 138, 229-237.
24. Gupta M, Mazumder UK, Kumar RS, Sivakumar T, Vamsi ML. (2004a). Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci, 94, 177-184. (Pubitemid 38405132)
25. Gupta M, Mazumder UK, Kumar RS, Kumar TS. (2004b). Antitumor activity and antioxidant role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice [corrected]. Acta Pharmacol Sin, 25, 1070-1076. (Pubitemid 39071116)
26. Habig WH, Pabst MJ, Jakoby WB. (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem, 249, 7130-7139.
27. Haldar PK, Kar B, Bala A, Bhattacharya S, Mazumder UK. (2010). Antitumor activity of Sansevieria roxburghiana rhizome against Ehrlich ascites carcinoma in mice. Pharm Biol, 48, 1337-1343.
28. Harborne JB. (1998). Phytochemical Methods, a Guide to Modern Techniques of Plant Analysis. 3rd ed. New Delhi: Springer (India) Pvt. Ltd.
29. Hogland HC. (1982). Hematological complications of cancer chemotherapy. Semin Oncol, 9, 95-102.
30. Jiau-Jian L, Larry WO. (1977). Over expression of manganesecontaining superoxide dismutase confers resistance to the cytotoxicity of tumor necrosis factor a and/or hyperthermia. Cancer Res, 57, 1991-1998.
31. Kabir S. (2000). The novel peptide composition of the seeds of Trichosanthes dioica Roxb. Cytobios, 103, 121-131.
32. Kakkar P, Das B, Viswanathan PN. (1984). A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys, 21, 130-132. (Pubitemid 15207169)
33. Kirtikar KR, Basu BD. (1935). Indian Medicinal Plants. New Delhi: Bishen Singh Mahendra Pal Singh.
34. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem, 193, 265-275.
35. Marklund SL, Westman NG, Lundgren E, Roos G. (1982). Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res, 42, 1955-1961. (Pubitemid 12103398)
36. Mascarenhas M. (1994). Structure-activity characterization, a quick method to screen mushrooms for the presence of antitumor glucans. Mushroom Res, 3, 77-80.
37. Meister A, Anderson ME. (1983). Glutathione. Annu Rev Biochem, 52, 711-760. (Pubitemid 13030692)
38. Miro M. (2006). Cucurbitacins and their pharmacological effects. Photother Res, 9, 159-168.
39. Mulder TP, Manni JJ, Roelofs HM, Peters WH, Wiersma A. (1995). Glutathione S-transferases and glutathione in human head and neck cancer. Carcinogenesis, 16, 619-624.
40. Nadkarni KM. (1976). Indian Materia Medica. Bombay: Popular Prakashan.
41. Neilson F, Mikkelson BB, Nielsen JB, Andersen HR, Grandjean P. (1997). Plasma malondialdehyde as biomarker for oxidative stress, reference interval and effects of life-style factors. Clin Chemist, 47, 1209-1214. (Pubitemid 27297265)
42. Nitha B, Meera CR, Janardhanan KK. (2005). Antitumor activity of ethanolic extract of Lentinus dicholamellatus. Amala Res Bull, 25, 165-168.
43. Oberley TD, Oberley LW. (1997). Antioxidant enzyme levels in cancer. Histol Histopathol, 12, 525-535. (Pubitemid 27240324)
44. Oberley TD. (2002). Oxidative damage and cancer. Am J Pathol, 160, 403-408. (Pubitemid 34160315)
45. Ohkawa H, Ohishi N, Yagi K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-358. (Pubitemid 9194347)
46. Pahl HL, Baeuerle PA. (1994). Oxygen and the control of gene expression. Bioessays, 16, 497-502.
47. Price VE, Greenfield RE. (1958). Anemia in cancer. In: Grenstein JP, Haddaw A. eds. Advances in Cancer Research. Vol. V. New York: Academic Press, pp. 199-200.
48. Rai PK, Jaiswal D, Rai DK, Sharma B, Watal G. (2008a). Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats. Indian J Clin Biochem, 23, 387-390.
49. Rai PK, Jaiswal D, Diwakar S, Watal G. (2008b). Antihyperglycemic profile of Trichosanthes dioica seeds in experimental models. Pharm Biol, 46, 360-365. (Pubitemid 351534437)
50. Segura JA, Barbero LG, Marquez J. (2000). Ehrlich ascites tumor unbalances splenic cell populations and reduced responsiveness of T cells to Staphylococcus aureus enterotoxin B Stimulation. Immunomol Lett, 74, 111-115.
51. Sharma G, Pant MC. (1988a). Preliminary observations on serum biochemical parameters of albino rabbits fed on seeds of Trichosanthes dioica (Roxb). Indian J Med Res, 87, 398-400.
52. Sharma G, Pant MC. (1988b). Effect of raw deseeded fruit powder of Trichosanthes dioica (Roxb) on blood sugar, serum cholesterol, high density lipo-protein, phospholipid and triglyceride levels in the normal albino rabbits. Indian J Physiol Pharmacol, 32, 161-163.
53. Sharma G, Pant MC. (1988c). Effect of feeding Trichosanthes dioica (Parval) whole fruits on blood glucose, serum triglycerides, phospholipid, cholesterol and high density lipoprotein-cholesterol levels in the normal albino rabbits. Curr Sci, 57, 1085-1087.
54. Sharma G, Pandey DN, Pant MC. (1990). Biochemical evaluation of feeding Trichosanthes dioica seeds in normal and mild diabetic human subjects in relation to lipid profile. Indian J Physiol Pharmacol, 34, 146-148. (Pubitemid 20331854)
55. Sharma R, Singhal SS, Srivastava SK, Bajpai KK, Frenkel EP, Awasthi S. (1993). Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines. Cancer Lett, 75, 111-119. (Pubitemid 24014534)
56. Sharma PC, Yelne MB, Dennis TJ. (2002). Database on Medicinal Plants Used in Ayurveda. New Delhi: Central Council for Research in Ayurveda and Siddha.
57. Sharmila BG, Kumar G, Rajasekara PM. (2007). Cholesterol lowering activity of the aqueous fruit extract of Trichosanthes dioica Roxb. in normal and streptozotocin diabetic rats. J Clin Diagnostic Res, 1, 561-569.
58. Stewart BS, Kleihues P. (2003). Cancers of female reproductive tract. In: World Cancer Report. Lyon, France: World Health Organization, International Agency for Research in Cancer, IARC Press.
59. Sultan NA, Kenoth R, Swamy MJ. (2004). Purification, physicochemical characterization, saccharide specificity, and chemical modification of a Gal/GalNAc specific lectin from the seeds of Trichosanthes dioica. Arch Biochem Biophys, 432, 212-221 (Pubitemid 39480731)
60. Sultan NA, Swamy MJ. (2005). Fluorescence quenching and timeresolved fluorescence studies on Trichosanthes dioica seed lectin. J Photochem Photobiol B, Biol, 80, 93-100. (Pubitemid 40984407)
61. Sur P, Ganguly DK. (1994). Tea plant root extract (TRE) as an antineoplastic agent. Planta Med, 60, 106-109. (Pubitemid 24120889)
62. Wagner H, Bladt B. (1996). Plant Drug Analysis, A Thin Layer Chromatography Atlas. Berlin Hiedelberg: Springer Verlag.
63. Wintrobe MM, Lee GR, Boggs DR, Bithel TC, Athens JW, Foerster J. (1961). Clinical Hematology. 5th ed. Philadelphia: Les & Febiger.
64. Yagi K. (1987). Lipid peroxides and human diseases. Chem Phys Lipids, 45, 337-351. (Pubitemid 17152340)
65. Yellin SA, Davidson BJ, Pinto JT, Sacks PG, Qiao C, Schantz SP. (1994). Relationship of glutathione and glutathione-S-transferase to cisplatin sensitivity in human head and neck squamous carcinoma cell lines. Cancer Lett, 85, 223-232. (Pubitemid 24302964)
66. Yoshikawa T, Tanaka H, Yoshida H, Sato O, Sugino N, Kondo M. (1983). Adjuvant arthritis and lipid peroxidation protection by superoxide dismutase, Lipid Peroxide Res, 7, 108-112.