The percutaneous permeation of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept®) through skin of different species in vitro

BMC Veterinary Research

Volumn 7, Issue , 2011, Pages

  Stahl, Jessica ^a   Braun, Michael ^b   Siebert, Joerg ^b   Kietzmann, Manfred ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b SCHÜLKE AND MAYR GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BOS; BOVINAE; CANIS FAMILIARIS; EQUIDAE; FELIDAE;

2 PHENOXYETHANOL; ETHYLENE GLYCOL DERIVATIVE; OCTENIDINE; PYRIDINE DERIVATIVE; TOPICAL ANTIINFECTIVE AGENT;

ANIMAL; ARTICLE; IN VITRO STUDY; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; SKIN; SKIN ABSORPTION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ETHYLENE GLYCOLS; PYRIDINES; SKIN; SKIN ABSORPTION;

EID: 80051512901     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-7-44     Document Type: Article

References (28)

1. Kramer A, O A, Mueller G, Reichwagen S, Widulle H, Heldt P, Nuernberg W. Octenidine, Chlorhexidine, Iodine and Iodophores. 2008, Stuttgart, New York: Georg Thieme.
2. Sedlock DM, Bailey DM. Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent. Antimicrob Agents Chemother 1985, 28:786-790. 180329, 3909955.
3. Pitten FA, Werner HP, Kramer A. A standardized test to assess the impact of different organic challenges on the antimicrobial activity of antiseptics. J Hosp Infect 2003, 55:108-115. 10.1016/S0195-6701(03)00260-3, 14529634.
4. Ghannoum MA, Elteen KA, Ellabib M, Whittaker PA. Antimycotic effects of octenidine and pirtenidine. J Antimicrob Chemother 1990, 25:237-245. 10.1093/jac/25.2.237, 2184158.
5. Harke HP. [Octenidine dihydrochloride, properties of a new antimicrobial agent]. Zentralbl Hyg Umweltmed 1989, 188:188-193.
6. Bailey DM, DeGrazia CG, Hoff SJ, Schulenberg PL, O'Connor JR, Paris DA, Slee AM. Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque. J Med Chem 1984, 27:1457-1464. 10.1021/jm00377a014, 6492075.
7. Emilson CG, Bowen WH, Robrish SA, Kemp CW. Effect of the antibacterial agents octenidine and chlorhexidine on the plaque flora in primates. Scand J Dent Res 1981, 89:384-392.
8. Patters MR, Nalbandian J, Nichols FC, Niekrash CE, Kennedy JE, Kiel RA, Trummel CL. Effects of octenidine mouthrinse on plaque formation and gingivitis in humans. J Periodontal Res 1986, 21:154-162. 10.1111/j.1600-0765.1986.tb01447.x, 2937903.
9. Shern RJ, Little WA, Kennedy JB, Mirth DB. Effects of octenidine on dental plaque and gingivitis in monkeys. J Periodontol 1987, 58:628-633.
10. Al-Doori Z, Goroncy-Bermes P, Gemmell CG, Morrison D. Low-level exposure of MRSA to octenidine dihydrochloride does not select for resistance. J Antimicrob Chemother 2007, 59:1280-1281. 10.1093/jac/dkm092, 17439976.
11. Mueller G, Kramer A. Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimicrob Chemother 2008, 61:1281-1287. 10.1093/jac/dkn125, 18364400.
12. Stahl J, Braun M, Siebert J, Kietzmann M. The effect of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) on wound healing in pigs in vivo and its in vitro percutaneous permeation through intact and barrier disrupted porcine skin. International wound journal 2010, 7:62-69. 10.1111/j.1742-481X.2009.00648.x, 20409252.
13. OECD Guideline 428 Skin absorption: in vitro method. 2004, http://www.oecd.org
14. Niedorf F, Schmidt E, Kietzmann M. The automated, accurate and reproducible determination of steady-state permeation parameters from percutaneous permeation data. Altern Lab Anim 2008, 36:201-213.
15. Kligman AM, Christophers E. Preparation of isolated sheets of human stratum corneum 4. Arch Dermatol 1963, 88:702-705.
16. Lademann J, Knorr F, Richter H, Blume-Peytavi U, Vogt A, Antoniou C, Sterry W, Patzelt A. Hair follicles--an efficient storage and penetration pathway for topically applied substances. Summary of recent results obtained at the Center of Experimental and Applied Cutaneous Physiology, Charite -Universitatsmedizin Berlin, Germany. Skin Pharmacol Physiol 2008, 21:150-155. 10.1159/000131079, 18523412.
17. Levit F. Cellophane tape stripping. Effects on guinea pig skin. ArchDermatol 1961, 84:609-612.
18. Pinkus H. Tape stripping in dermatological research. A review with emphasis on epidermal biology. GItalDermatolMinerva Dermatol 1966, 107:1115-1126.
19. Rissmann R, Oudshoorn MH, Hennink WE, Ponec M, Bouwstra JA. Skin barrier disruption by acetone: observations in a hairless mouse skin model. Arch Dermatol Res 2009, 301:609-13. 10.1007/s00403-009-0946-6, 2728065, 19350255.
20. Jun Choi M, Zhai H, Löffler H, Dreher F, Maibach HI. Effect of Tape Stripping on Percutaneous Penetration and Topical Vaccination. Exog Dermatol 2003, 2:262-269.
21. Netzlaff F, Schaefer UF, Lehr CM, Meiers P, Stahl J, Kietzmann M, Niedorf F. Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments 1. AlternLab Anim 2006, 34:499-513.
22. Magnusson BM, Walters KA, Roberts MS. Veterinary drug delivery: potential for skin penetration enhancement. Adv Drug Deliv Rev 2001, 50:205-227. 10.1016/S0169-409X(01)00158-2, 11500228.
23. Stahl J, Niedorf F, Kietzmann M. Characterisation of epidermal lipid composition and skin morphology of animal skin ex vivo. Eur J Pharm Biopharm 2009, 72:310-316. 10.1016/j.ejpb.2008.09.013, 18940254.
24. Bronaugh RL, Stewart RF, Simon M. Methods for in vitro percutaneous absorption studies. VII: Use of excised human skin. JPharmSci 1986, 75:1094-1097.
25. Ahlstrom LA, Cross SE, Mills PC. The effects of freezing skin on transdermal drug penetration kinetics. J Vet Pharmacol Ther 2007, 30:456-463. 10.1111/j.1365-2885.2007.00879.x, 17803739.
26. Roper CS, Howes D, Blain PG, Williams FM. Percutaneous penetration of 2-phenoxyethanol through rat and human skin. Food Chem Toxicol 1997, 35:1009-1016. 10.1016/S0278-6915(97)00109-9, 9463535.
27. Buhrer C, Bahr S, Siebert J, Wettstein R, Geffers C, Obladen M. Use of 2% 2-phenoxyethanol and 0.1% octenidine as antiseptic in premature newborn infants of 23-26 weeks gestation. J Hosp Infect 2002, 51:305-307. 10.1053/jhin.2002.1249, 12183146.
28. Stahl J, Niedorf F, Kietzmann M. The correlation between epidermal lipid composition and morphologic skin characteristics with percutaneous permeation: an interspecies comparison of substances with different lipophilicity. J vet Pharmacol Therap