Genetic vulnerability and premature death in schizophrenia spectrum disorders: A 28-year follow-up of adoptees in the Finnish Adoptive Family Study of Schizophrenia

Nordic Journal of Psychiatry

Volumn 65, Issue 4, 2011, Pages 259-265

  Hakko, Helinä ^a   Wahlberg, Karl Erik ^b   Tienari, Pekka ^b   Räsänen, Sami ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

Adoption study; Environmental risk; Genetic risk; Mortality; Schizophrenia spectrum disorders

Indexed keywords

ADULT; ARTICLE; CLINICAL PRACTICE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ENVIRONMENTAL FACTOR; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; MALE; MENTAL DISEASE; MORTALITY; RISK FACTOR; SCHIZOPHRENIA; SURVIVAL;

ADOLESCENT; ADOPTION; ADULT; CHILD; CHILD, PRESCHOOL; ENVIRONMENT; FAMILY; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIFE EXPECTANCY; MALE; MIDDLE AGED; PARENTS; PSYCHOTIC DISORDERS; RISK; SCHIZOPHRENIA; SOCIAL ENVIRONMENT; YOUNG ADULT;

EID: 80051499889     PISSN: 08039488     EISSN: 15024725     Source Type: Journal    
DOI: 10.3109/08039488.2010.540039     Document Type: Article

References (33)

1. Brown S. Excess mortality of schizophrenia. A meta-analysis. Br J Psychiatry 1997;171:502-8.
2. Harris EC, Barraclough B. Excess mortality of mental disorder. Br J Psychiatry 1998;173:11-53. (Pubitemid 28312203)
3. Joukamaa M, Heli övaara M, Knekt P, Aromaa A, Raitasalo R, Lehtinen V. Mental disorders and cause-specifi c mortality. Br J Psychiatry 2001;179:498-502.
4. Leucht S, Burkard T, Henderson J, Maj M, Sartorius N. Physical illness and schizophrenia: A review of the literature. Acta Psychiatr Scand 2007;116:317-33. (Pubitemid 47537428)
5. R ä s ä nen S, Hakko H, Viilo K, Meyer-Rochow VB, Moring J. Excess mortality among long-stay psychiatric patients in Northern Finland. Soc Psychiatry Psychiatr Epidemiol 2003;38:297-304. (Pubitemid 37160798)
6. Ösby U, Correia N, Brandt L, Ekbom A, Sparen P. Mortality and causes of death in schizophrenia in Stockholm County, Sweden. Schizophr Res 2000;45:21-8.
7. Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia. Is the differential mortality gap worsening over time? Arch Gen Psychiatry 2007;64:1123-31. (Pubitemid 47529346)
8. Brown S, Birtwistle J, Roe I, Thompson C. The unhealthy lifestyle of people with schizophrenia. Psychol Med 1999;29:697-701. (Pubitemid 29261358)
9. Dixon L, Postrado L, Delahanty J, Fischer PJ, Lehman A. The association of medical comorbidity in schizophrenia with poor physical and mental health. J Nerv Ment Dis 2000;187:496-502. (Pubitemid 29422604)
10. Jones DR, Macias C, Barreira PJ, Fisher WH, Hargreaves WA, Harding CM. Prevalence, severity, and co-occurrence of chronic physical health problems of persons with serious mental illness. Psychiatr Serv 2004;55:1250-7.
11. R ä s ä nen S, Meyer-Rochow VB, Moring J, Hakko H. Hospitaltreated physical illness and mortality: An 11-year follow-up study of long-stay psychiatric patients. Eur Psychiatry 2007;22:211-8. (Pubitemid 46727012)
12. Eaton WW, Byrne M, Ewald H, Mors O, Chen CY, Agerbo E, et al. Association of schizophrenia and autoimmune diseases: Linkage of Danish national registers. Am J Psychiatry 2006;163: 521-8. (Pubitemid 44469397)
13. Tienari P, Lahti I, Sorri A, Naarala M, Wahlberg KE, Rönkk öT, et al. The Finnish adoptive family study of schizophrenia: Possible joint effects of genetic vulnerability and family interaction. In: Halweg K, Goldstein MJ, editors. Understanding major mental disorder: The contribution of family interaction research. New York: Family Process Press; 1987. p. 33 - 54.
14. Tienari P, Wynne LC, Moring J, Lä ksy K, Nieminen P, Sorri A, et al. Finnish Adoptive Family Study: Sample selection and adoptee DSM-III-R diagnoses. Acta Psychiatr Scand 2000;101: 433-43. (Pubitemid 30365565)
15. Kendler KS. A twin study of mortality in schizophrenia and neurosis. Arch Gen Psychiatry 1986;43:643-9. (Pubitemid 16094175)
16. Tienari P, Wynne LC, Lä ksy K. Genetic boundaries of the schizophrenia spectrum: Evidence from the Finnish Adoptive Family Study of Schizophrenia. Am J Psychiatry 2003;160: 1587-94. (Pubitemid 41079543)
17. Wing JK, Cooper JE, Sartorius N. Measurement and classifi cation of psychiatric symptoms: An instruction manual for the PSE and Catego Program. Cambridge University Press, Cambridge, 1974.
18. Spizer RL, Williams JBW, Gibbon M, First MB. Structured clinical interview for DSM-II-R personality disorders (SCID-II). Biometrics Research Department, New York State Psychiatric Institute, New York, 1989.
19. Kendler KS, Liberman JA, Waldh D The structured interview for schizotypy (SIS). A preliminary report. Schizophr Bull 1989;15: 559-71. (Pubitemid 20066724)
20. Kendler KS, O'Neill FA, Burke J, Murphy B, Duke F, Straub RE, et al. Irish study of high-density schizophrenia families: Field methods and power to detect linkage. Am J Med Genet 1996;67:179-90.
21. Statistics Finland. Causes of death 2000. Helsinki: Offi cial Statistics of Finland; 2000.
22. L ahti RA, Penttilä A. The validity of death certifi cates: Routine validation of death certifi cation and its effects on mortality statistics. Forensic Sci Int 2001;115:15-32.
23. Tienari P, Wynne LC, Sorri A, Lahti I, Moring J, Nieminen P, et al. Observing relationships in Finnish adoptive families: Oulu Family Rating Scale. Nord J Psychiatry 2005;59:253-63. (Pubitemid 41670872)
24. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4rd edition. Washington DC: American Psychiatric Association; 1994.
25. Central Statistical Offi ce of Finland. Classifi cation of socioeconomic status, handbook 17. Helsinki: The Central Statistical Offi ce of Finland; 1983.
26. Tienari P, Wynne LC, Sorri A, Lahti I, Lä ksy K, Moring J, et al. Genotype-environment interaction in schizophrenia-spectrum disorder. Long-term follow-up study of Finnish adoptees. Br J Psychiatry 2004;184:216-22. (Pubitemid 38333760)
27. Wahlberg KE, Wynne LC, Hakko H, Lä k sy K, Moring J, Miettunen J, et al. Interaction of genetic risk and adoptive parent communication deviance: Longitudinal prediction of adoptee psychiatric disorders. Psychol Med 2004;34:1531-41. (Pubitemid 39599950)
28. Wahlberg KE, Wynne LC, Oja H, Keskitalo P, Pykä l ä inen L, Lahti I, et al. Gene-environment interaction in vulnerability to schizophrenia: Findings from the Finnish Adoptive Family Study of Schizophrenia. Am J Psychiatry 1997;154:355-62. (Pubitemid 27098285)
29. Wynne LC, Tienari P, Nieminen P, Sorri A, Lahti I, Moring J, et al. Genotype - environment interaction in the schizophrenia spectrum: Genetic liability and global family ratings in the Finnish Adoption Study. Fam Process 2006;45:419-34. (Pubitemid 44610883)
30. Q in P, Agerbo E, Mortensen PB. Suicide risk in relation to socioeconomic, demographic, psychiatric, and familial factors: A national register-based study of all suicides in Denmark, 1981 - 1997. Am J Psychiatry 2003;160:765-72.
31. Webb RT, Pickels AR, Appleby L, Mortensen PB, Abel KM. Death byunnatural causes during childhood and early adulthood in offspring of psychiatric inpatients. Arch Gen Psychiatry 2007;64:345-52. (Pubitemid 46376785)
32. Iachine IA, Holm NV, Harris JR, Begun AZ, Iachina MK, Laitinen M, et al. How heritable is the individual susceptibility to death? The results of an analysis of survival data on Danish, Swedish and Finnish twins. Twin Res 1998;1:196-205. (Pubitemid 128560442)
33. Petersen L, Andersen PK, Sorensen TIA Premature death of adult adoptees: Analyses of a case-cohort sample. Genet Epidemiol 2005;28:376-82. (Pubitemid 40559549)