Predictors of thyroid hormone initiation in older adults: Results from the cardiovascular health study

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 66 A, Issue 7, 2011, Pages 809-814

  Somwaru, Lily L ^a   Arnold, Alice M ^b   Cappola, Anne R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Elderly population; Levothyroxine; Thyroid hormone

Indexed keywords

THYROID HORMONE; THYROXINE;

AGED; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; FEMALE; FOLLOW UP; HUMAN; HYPOTHYROIDISM; INCIDENCE; MALE; MULTICENTER STUDY; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDY; RISK FACTOR; SEX DIFFERENCE; TIME; UNITED STATES;

AGED; AGED, 80 AND OVER; BODY MASS INDEX; CARDIOVASCULAR DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOTHYROIDISM; INCIDENCE; MALE; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; THYROID HORMONES; THYROXINE; TIME FACTORS; UNITED STATES;

EID: 80051495474     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr063     Document Type: Article

References (32)

1. Doucet J, Trivalle C, Chassagne P, et al. Does age play a role in clinical presentation of hypothyroidism? J Am Geriatr Soc. 1994;42:984-986. (Pubitemid 24280375)
2. Cappola AR, Fried LP, Arnold AM, et al. Thyroid status, cardiovascular risk, and mortality in older adults. JAMA. 2006;295:1033-1041.
3. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT. Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. J Clin Endocrinol Metab. 2005;90:581-585. (Pubitemid 40116712)
4. Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004;291:228-238. (Pubitemid 38082818)
5. Fried LP, Borhani NO, Enright P, et al. The Cardiovascular Health Study: design and rationale. Ann Epidemiol. 1991;1:263-276.
6. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20:1183-1197.
7. Psaty BM, Kuller LH, Bild D, et al. Methods of assessing prevalent cardiovascular disease in the Cardiovascular Health Study. Ann Epidemiol. 1995;5:270-277.
8. Kanaya AM, Harris F, Volpato S, Perez-Stable EJ, Harris T, Bauer DC. Association between thyroid dysfunction and total cholesterol level in an older biracial population: the health, aging and body composition study. Arch Intern Med. 2002;162:773-779. (Pubitemid 34273299)
9. Bauer DC, Rodondi N, Stone KL, Hillier TA. Thyroid hormone use, hyperthyroidism and mortality in older women. Am J Med. 2007;120:343-349. (Pubitemid 46483309)
10. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87:489-499. (Pubitemid 34158210)
11. Boucai L, Surks MI. Reference limits of serum TSH and free T4 are significantly influenced by race and age in an urban outpatient medical practice. Clin Endocrinol (Oxf). 2009;70:788-793.
12. Hamilton TE, Davis S, Onstad L, Kopecky KJ. Thyrotropin levels in a population with no clinical, autoantibody, or ultrasonographic evidence of thyroid disease: implications for the diagnosis of subclinical hypothyroidism. J Clin Endocrinol Metab. 2008;93:1224-1230. (Pubitemid 351519714)
13. Bagchi N, Brown TR, Parish RF. Thyroid dysfunction in adults over age 55 years. A study in an urban US community. Arch Intern Med. 1990;150:785-787. (Pubitemid 20122054)
14. Asvold BO, Bjoro T, Vatten LJ. Association of serum TSH with high body mass differs between smokers and never-smokers. J Clin Endocrinol Metab. 2009;94:5023-5027.
15. Chikunguwo S, Brethauer S, Nirujogi V, et al. Influence of obesity and surgical weight loss on thyroid hormone levels. Surg Obes Relat Dis. 2007;3:631-635. (Pubitemid 350091416)
16. Gussekloo J, van EE, de Craen AJ, Meinders AE, Frolich M, Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. JAMA. 2004;292:2591-2599. (Pubitemid 39577515)
17. Rozing MP, Westendorp RG, de Craen AJ, et al. Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. J Gerontol A Biol Sci Med Sci. 2010;65:365-368.
18. Formiga F, Ferrer A. Thyrotropin serum values and 3-year mortality in nonagenarians. J Gerontol A Biol Sci Med Sci. 2010;65:1250-1251.
19. Simonsick EM, Newman AB, Ferrucci L, et al. Subclinical hypothyroidism and functional mobility in older adults. Arch Intern Med. 2009;169:2011-2017.
20. Forrest KY, Zmuda JM, Cauley JA. Correlates of decline in lower extremity performance in older women: a 10-year follow-up study. J Gerontol A Biol Sci Med Sci. 2006;61:1194-1200. (Pubitemid 46034472)
21. Somwaru LL, Arnold AM, Joshi N, Fried LP, Cappola AR. High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over. J Clin Endocrinol Metab. 2009;94:1342-1345.
22. Diez JJ. Hypothyroidism in patients older than 55 years: an analysis of the etiology and assessment of the effectiveness of therapy. J Gerontol A Biol Sci Med Sci. 2002;57:M315-M320. (Pubitemid 34464972)
23. Sawin CT, Geller A, Wolf PA, et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med. 1994;331:1249-1252. (Pubitemid 24333188)
24. Bauer DC, Ettinger B, Nevitt MC, Stone KL. Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann Intern Med. 2001;134:561-568. (Pubitemid 32245317)
25. Ceresini G, Lauretani F, Maggio M, et al. Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study. J Am Geriatr Soc. 2009;57:89-93.
26. U.S. Census Bureau. U.S. Interim Projections by Age, Sex, Race, and Hispanic Origin. 2004. U.S. Census Bureau Web site. http://www.census.gov/ipc/ www/usinterimproj. Accessed March 18, 2004.
27. Espino DV, Bazaldua OV, Palmer RF, et al. Suboptimal medication use and mortality in an older adult community-based cohort: results from the Hispanic EPESE Study. J Gerontol A Biol Sci Med Sci. 2006;61:170-175. (Pubitemid 43334613)
28. Bernabei R, Caputi A, Di CL, et al. Need for redesigning pharmacologic research in older individuals. A position statement of the Geriatric Working Group of the Agenzia Italiana del Farmaco (AIFA). J Gerontol A Biol Sci Med Sci. 2011;66:66-67.
29. IMS Health. IMS National Sales Perspectives. 2009. www.imshealth.com. Accessed August 10, 2010.
30. Surks MI, Hollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab. 2007;92:4575-4582. (Pubitemid 350223429)
31. Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304:1365-1374.
32. Rodondi N, Bauer DC, Cappola AR, et al. Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure. The Cardiovascular Health Study. J Am Coll Cardiol. 2008;52:1152-1159.