Synthesis of phenylacetic acid regioisomers possessing an N-substituted 1,2-dihydropyrid-2-one pharmacophore - Evaluation as inhibitors of cyclooxygenases and 5-lipoxygenase

Canadian Journal of Chemistry

Volumn 89, Issue 6, 2011, Pages 617-622

  Yu, Gang ^a   Chowdhury, Morshed A ^a   Huang, Zhangjian ^a   Abdellatif, Khaled R A ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

1,2 dihydropyrid 2 ones; cyclooxygenase (COX) and 5 lipoxygenase (5 LOX) inhibition; Suzuki Miyaura cross coupling reaction

Indexed keywords

1,2-DIHYDROPYRID-2-ONES; CYCLOOXYGENASES; MEDICINAL CHEMISTRY; PHARMACOPHORES; PHENYLACETIC ACID; REGIOISOMERS; RING SYSTEMS; SUZUKI-MIYAURA CROSS-COUPLING REACTION; SYNTHONS;

CARBOXYLIC ACIDS; CHEMICAL BONDS; SUBSTITUTION REACTIONS;

SYNTHESIS (CHEMICAL);

EID: 80051487954     PISSN: 00084042     EISSN: None     Source Type: Journal    
DOI: 10.1139/v11-048     Document Type: Article

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