Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Sales, Katiuchia Uzzun ^a   Hobson, John P ^a,c   Wagenaar Miller, Rebecca ^a   Szabo, Roman ^a   Rasmussen, Amber L ^a   Bey, Alexandra ^a,b   Shah, Maham F ^a   Molinolo, Alfredo A ^a   Bugge, Thomas H ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPSIN; MATRIPTASE; RNA; HUMAN AIRWAY TRYPSIN LIKE PROTEASE; HUMAN AIRWAY TRYPSIN-LIKE PROTEASE; MEMBRANE PROTEIN; MESSENGER RNA; SERINE PROTEINASE; TMPRSS11A PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC ANALYSIS; HAT GENE; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MALE; MOUSE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHENOTYPE; PHYLOGENY; PHYSICAL DEVELOPMENT; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SURVIVAL RATE; TMPRSS11A GENE; AGING; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEALTH; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; SURVIVAL;

MURINAE; MUS;

AGING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GROWTH AND DEVELOPMENT; HEALTH; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; ORGAN SPECIFICITY; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SERINE PROTEASES; SURVIVAL ANALYSIS;

EID: 80051482012     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023261     Document Type: Article

References (45)

1. Hooper JD, Clements JA, Quigley JP, Antalis TM, (2001) Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem 276: 857-860.
2. Antalis TM, Bugge TH, Wu Q, Membrane-anchored serine proteases in health and disease. Prog Mol Biol Transl Sci 99: 1-50.
3. Bugge TH, Antalis TM, Wu Q, (2009) Type II transmembrane serine proteases. J Biol Chem 284: 23177-23181.
4. Szabo R, Wu Q, Dickson RB, Netzel-Arnett S, Antalis TM, et al. (2003) Type II transmembrane serine proteases. Thromb Haemost 90: 185-193.
5. Netzel-Arnett S, Hooper JD, Szabo R, Madison EL, Quigley JP, et al. (2003) Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev 22: 237-258.
6. Szabo R, Bugge TH, (2008) Type II transmembrane serine proteases in development and disease. Int J Biochem Cell Biol 40: 1297-1316.
7. Hobson JP, Netzel-Arnett S, Szabo R, Rehault SM, Church FC, et al. (2004) Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. J Biol Chem.
8. Quesada V, Ordonez GR, Sanchez LM, Puente XS, Lopez-Otin C, (2009) The Degradome database: mammalian proteases and diseases of proteolysis. Nucleic Acids Res 37: D239-243.
9. Stallmach R, Gloor SM, (2008) Neurobin/TMPRSS11c, a novel type II transmembrane serine protease that cleaves fibroblast growth factor-2 in vitro. Biochem J 412: 81-91.
10. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C, (2003) Human and mouse proteases: a comparative genomic approach. Nat Rev Genet 4: 544-558.
11. Lang JC, Schuller DE, (2001) Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck. Br J Cancer 84: 237-243.
12. Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, et al. (1998) Cloning and characterization of the cDNA for human airway trypsin-like protease. J Biol Chem 273: 11895-11901.
13. Zheng XL, Kitamoto Y, Sadler JE, (2009) Enteropeptidase, a type II transmembrane serine protease. Front Biosci (Elite Ed) 1: 242-249.
14. List K, Haudenschild CC, Szabo R, Chen W, Wahl SM, et al. (2002) Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene 21: 3765-3779.
15. Basel-Vanagaite L, Attia R, Ishida-Yamamoto A, Rainshtein L, Ben Amitai D, et al. (2007) Autosomal Recessive Ichthyosis with Hypotrichosis Caused by a Mutation in ST14, Encoding Type II Transmembrane Serine Protease Matriptase. Am J Hum Genet 80: 467-477.
16. Du X, She E, Gelbart T, Truksa J, Lee P, et al. (2008) The serine protease TMPRSS6 is required to sense iron deficiency. Science 320: 1088-1092.
17. Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, et al. (2008) Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 40: 569-571.
18. Folgueras AR, de Lara FM, Pendas AM, Garabaya C, Rodriguez F, et al. (2008) Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood 112: 2539-2545.
19. Guipponi M, Tan J, Cannon PZ, Donley L, Crewther P, et al. (2007) Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss. Am J Pathol 171: 608-616.
20. Scott HS, Kudoh J, Wattenhofer M, Shibuya K, Berry A, et al. (2001) Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness. Nat Genet 27: 59-63.
21. Guipponi M, Toh MY, Tan J, Park D, Hanson K, et al. (2008) An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Hum Mutat 29: 130-141.
22. Wu F, Yan W, Pan J, Morser J, Wu Q, (2002) Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes. J Biol Chem 277: 16900-16905.
23. Yan W, Wu F, Morser J, Wu Q, (2000) Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. Proc Natl Acad Sci U S A 97: 8525-8529.
24. Dries DL, Victor RG, Rame JE, Cooper RS, Wu X, et al. (2005) Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. Circulation 112: 2403-2410.
25. Chan JC, Knudson O, Wu F, Morser J, Dole WP, et al. (2005) Hypertension in mice lacking the proatrial natriuretic peptide convertase corin. Proc Natl Acad Sci U S A 102: 785-790.
26. Enshell-Seijffers D, Lindon C, Morgan BA, (2008) The serine protease Corin is a novel modifier of the Agouti pathway. Development 135: 217-225.
27. Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, et al. (1997) Purification, characterization, and localization of a novel trypsin-like protease found in the human airway. Am J Respir Cell Mol Biol 16: 300-308.
28. Yoshinaga S, Nakahori Y, Yasuoka S, (1998) Fibrinogenolytic activity of a novel trypsin-like enzyme found in human airway. J Med Invest 45: 77-86.
29. Iwakiri K, Ghazizadeh M, Jin E, Fujiwara M, Takemura T, et al. (2004) Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris. J Invest Dermatol 122: 937-944.
30. Matsushima R, Takahashi A, Nakaya Y, Maezawa H, Miki M, et al. (2006) Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway. Am J Physiol Lung Cell Mol Physiol 290: L385-395.
31. Chokki M, Eguchi H, Hamamura I, Mitsuhashi H, Kamimura T, (2005) Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. Febs J 272: 6387-6399.
32. Chokki M, Yamamura S, Eguchi H, Masegi T, Horiuchi H, et al. (2004) Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells. Am J Respir Cell Mol Biol 30: 470-478.
33. Beaufort N, Leduc D, Eguchi H, Mengele K, Hellmann D, et al. (2007) The human airway trypsin-like protease modulates the urokinase receptor (uPAR, CD87) structure and functions. Am J Physiol Lung Cell Mol Physiol 292: L1263-1272.
34. Bicknell AB, Lomthaisong K, Woods RJ, Hutchinson EG, Bennett HP, et al. (2001) Characterization of a serine protease that cleaves pro-gamma-melanotropin at the adrenal to stimulate growth. Cell 105: 903-912.
35. Hansen IA, Fassnacht M, Hahner S, Hammer F, Schammann M, et al. (2004) The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease. Endocrinology 145: 1898-1905.
36. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC, (1993) Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A 90: 8424-8428.
37. Adams DJ, Biggs PJ, Cox T, Davies R, van der Weyden L, et al. (2004) Mutagenic insertion and chromosome engineering resource (MICER). Nat Genet 36: 867-871.
38. Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, et al. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol 9: e1000582.
39. Szabo R, Bugge TH, (2011) Membrane anchored serine proteases in cell and developmental biology. Annu Rev Cell and Developmental Biology In press.
40. Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, et al. (2010) Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell 18: 25-38.
41. Meyer M, de Angelis MH, Wurst W, Kuhn R, Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci U S A 107: 15022-15026.
42. Fasquelle L, Scott HS, Lenoir M, Wang J, Rebillard G, et al. Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing. J Biol Chem.
43. Kim TS, Heinlein C, Hackman RC, Nelson PS, (2006) Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Mol Cell Biol 26: 965-975.
44. Ben-Yosef T, Wattenhofer M, Riazuddin S, Ahmed ZM, Scott HS, et al. (2001) Novel mutations of TMPRSS3 in four DFNB8/B10 families segregating congenital autosomal recessive deafness. J Med Genet 38: 396-400.
45. Holzinger A, Maier EM, Buck C, Mayerhofer PU, Kappler M, et al. (2002) Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency. Am J Hum Genet 70: 20-25.