Triggered release of pharmacophores from [Ni(HAsO3)]-loaded polymer-caged nanobin enhances pro-apoptotic activity: A combined experimental and theoretical study

ACS Nano

Volumn 5, Issue 5, 2011, Pages 3961-3969

  Lee, Sang Min ^a   Lee, One Sun ^a   O'Halloran, Thomas V ^a   Schatz, George C ^a   Nguyen, SonBinh T ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Arsenic trioxide; Drug delivery; Liposome; Molecular modeling; pH sensitive release; Polymer

Indexed keywords

ACIDIC CONDITIONS; ACTIVE AGENTS; ACUTE TOXICITY; ADVERSE SIDE EFFECTS; AMPHIPATHIC; ANTI-CANCER AGENTS; ARSENIC TRIOXIDE; ATTRACTIVE STRATEGIES; COMPUTATIONAL MODELING; CONFORMATION CHANGE; CROSS-LINKED POLYMERS; DRUG RELEASE; LATE ENDOSOMES; MEMBRANE-PERMEABLE; MULTICOMPONENTS; NANO SCALE; PH SENSITIVE; PHARMACOPHORES; POLYMER NETWORKS; SIDE EFFECT; SMALL MOLECULES; TEMPERATURE-RESPONSIVE; THEORETICAL STUDY; THERAPEUTIC EFFICACY; THERAPEUTIC STRATEGY; TRIGGERED RELEASE; TUMOR TISSUES;

ARSENIC; DRUG DELIVERY; DRUG INTERACTIONS; NANOSTRUCTURED MATERIALS; NANOTECHNOLOGY; PH EFFECTS; TUMORS;

FUNCTIONAL POLYMERS;

ANTINEOPLASTIC AGENT; NANOCAPSULE; NICKEL; POLYMER;

APOPTOSIS; ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DELAYED RELEASE FORMULATION; DRUG EFFECT; DRUG POTENTIATION; HELA CELL; HUMAN; MATERIALS TESTING; PH;

ANTINEOPLASTIC AGENTS; APOPTOSIS; COMPUTER SIMULATION; DELAYED-ACTION PREPARATIONS; DRUG SYNERGISM; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MATERIALS TESTING; MODELS, CHEMICAL; NANOCAPSULES; NICKEL; POLYMERS;

EID: 80051478841     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn200478m     Document Type: Article

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