메뉴 건너뛰기




Volumn 58, Issue 2, 2012, Pages 385-398

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

Author keywords

Computational fluid dynamics; Crystallization (precipitation); Supercritical processes; Turbulence

Indexed keywords

MICRO-SCALES; MIXING DEVICES; MIXING DYNAMICS; MIXING EFFECTS; NUTRACEUTICALS; PARTICLE FORMATIONS; PARTICLE PRODUCTION; PARTICULATE SYSTEMS; PROPER DESIGN; SMALL PARTICLES; SUPERCRITICAL ANTISOLVENT PRECIPITATION; SUPERCRITICAL ANTISOLVENTS; SUPERCRITICAL PROCESS;

EID: 80051473422     PISSN: 00011541     EISSN: 15475905     Source Type: Journal    
DOI: 10.1002/aic.12594     Document Type: Article
Times cited : (48)

References (47)
  • 1
    • 0034964315 scopus 로고    scopus 로고
    • Particle design using supercritical fluids: Literature and patent survey
    • Jung J, Perrut M. Particle design using supercritical fluids: Literature and patent survey. J Supercrit Fluids. 2001; 20: 179-219.
    • (2001) J Supercrit Fluids. , vol.20 , pp. 179-219
    • Jung, J.1    Perrut, M.2
  • 2
    • 29144504424 scopus 로고    scopus 로고
    • Nanomaterials and supercritical fluids
    • Reverchon E, Adami R. Nanomaterials and supercritical fluids. J Supercrit Fluids. 2006; 37: 1-22.
    • (2006) J Supercrit Fluids. , vol.37 , pp. 1-22
    • Reverchon, E.1    Adami, R.2
  • 3
    • 38949158749 scopus 로고    scopus 로고
    • Micronization processes with supercritical fluids: Fundamentals and mechanisms
    • Martín A, Cocero M. Micronization processes with supercritical fluids: Fundamentals and mechanisms. Adv Drug Delivery Rev. 2008; 60: 339-350.
    • (2008) Adv Drug Delivery Rev. , vol.60 , pp. 339-350
    • Martín, A.1    Cocero, M.2
  • 5
    • 22944455557 scopus 로고    scopus 로고
    • Interaction between mixing, chemical reactions, and precipitation
    • Bałdyga J, Makowski L, Orciuch W. Interaction between mixing, chemical reactions, and precipitation. Ind Eng Chem Res. 2005; 44: 5342-5352.
    • (2005) Ind Eng Chem Res. , vol.44 , pp. 5342-5352
    • Bałdyga, J.1    Makowski, L.2    Orciuch, W.3
  • 6
    • 0343807209 scopus 로고    scopus 로고
    • Particle formation by mixing with supercritical antisolvent at high Reynolds numbers
    • Shekunov BY, Baldyga J, York P. Particle formation by mixing with supercritical antisolvent at high Reynolds numbers. Chem Eng Sci. 2001; 56: 2421-2433.
    • (2001) Chem Eng Sci. , vol.56 , pp. 2421-2433
    • Shekunov, B.Y.1    Baldyga, J.2    York, P.3
  • 7
    • 0034632664 scopus 로고    scopus 로고
    • Numerical modeling of mass transfer in the supercritical antisolvent process: miscible conditions
    • Werling J, Debenedetti P. Numerical modeling of mass transfer in the supercritical antisolvent process: miscible conditions. J Supercrit Fluids. 2000; 18: 11-24.
    • (2000) J Supercrit Fluids. , vol.18 , pp. 11-24
    • Werling, J.1    Debenedetti, P.2
  • 8
    • 0038310805 scopus 로고    scopus 로고
    • Estimation of the characteristic time scales in the supercritical antisolvent process
    • Chavez F, Debenedetti P, Luo J, Dave R, Pfeffer R. Estimation of the characteristic time scales in the supercritical antisolvent process. Ind Eng Chem Res. 2003; 42: 3156-3162.
    • (2003) Ind Eng Chem Res , vol.42 , pp. 3156-3162
    • Chavez, F.1    Debenedetti, P.2    Luo, J.3    Dave, R.4    Pfeffer, R.5
  • 9
    • 14344266592 scopus 로고    scopus 로고
    • Numerical modeling of jet hydrodynamics, mass transfer and crystallization kinetics in the supercritical antisolvent (SAS) process
    • Martín A, Cocero MJ. Numerical modeling of jet hydrodynamics, mass transfer and crystallization kinetics in the supercritical antisolvent (SAS) process. J Supercritical Fluids. 2004; 32: 203-219.
    • (2004) J Supercritical Fluids. , vol.32 , pp. 203-219
    • Martín, A.1    Cocero, M.J.2
  • 10
    • 0024064150 scopus 로고
    • Simultaneous nucleation, condensation, and coagulation in aerosol reactors
    • Pratsinis SE. Simultaneous nucleation, condensation, and coagulation in aerosol reactors. J Colloid Interface Sci. 1988; 124: 416-427.
    • (1988) J Colloid Interface Sci. , vol.124 , pp. 416-427
    • Pratsinis, S.E.1
  • 11
    • 14544306500 scopus 로고    scopus 로고
    • Particle formation by turbulent mixing with supercritical antisolvent
    • Henczka M, Bałdyga J, Shekunov B. Particle formation by turbulent mixing with supercritical antisolvent. Chem Eng Sci. 2005; 60: 2193-2201.
    • (2005) Chem Eng Sci. , vol.60 , pp. 2193-2201
    • Henczka, M.1    Bałdyga, J.2    Shekunov, B.3
  • 12
    • 0024940983 scopus 로고
    • Turbulent mixer model with application to homogeneous, instantaneous chemical reactions
    • Bałdyga J. Turbulent mixer model with application to homogeneous, instantaneous chemical reactions. Chem Eng Sci. 1989; 44: 1175-82.
    • (1989) Chem Eng Sci. , vol.44 , pp. 1175-1182
    • Bałdyga, J.1
  • 14
    • 0022699554 scopus 로고
    • PRSV: An improved Peng-Robinson equation of state for pure compounds and mixtures
    • Stryjek R, Vera JH. PRSV: An improved Peng-Robinson equation of state for pure compounds and mixtures. Can J Chem Eng. 1986; 64: 323-333.
    • (1986) Can J Chem Eng. , vol.64 , pp. 323-333
    • Stryjek, R.1    Vera, J.H.2
  • 15
    • 0031339103 scopus 로고    scopus 로고
    • A thermodynamic analysis of three-phase equilibria in binary and ternary systems for applications in rapid expansion of a supercritical solution (RESS), particles from gas-saturated solutions (PGSS), and supercritical antisolvent (SAS)
    • Kikic I, Lora M, Bertucco A. A thermodynamic analysis of three-phase equilibria in binary and ternary systems for applications in rapid expansion of a supercritical solution (RESS), particles from gas-saturated solutions (PGSS), and supercritical antisolvent (SAS). Ind Eng Chem Res. 1997; 36: 5507-5515.
    • (1997) Ind Eng Chem Res. , vol.36 , pp. 5507-5515
    • Kikic, I.1    Lora, M.2    Bertucco, A.3
  • 16
    • 67349162938 scopus 로고    scopus 로고
    • Particle diameter prediction in supercritical nanoparticle synthesis using three-dimensional CFD simulations. Validation for anatase titanium dioxide production
    • Sierra-Pallares J, Alonso E, Montequi I, Cocero M. Particle diameter prediction in supercritical nanoparticle synthesis using three-dimensional CFD simulations. Validation for anatase titanium dioxide production. Chem Eng Sci. 2009; 64: 3051-3059.
    • (2009) Chem Eng Sci. , vol.64 , pp. 3051-3059
    • Sierra-Pallares, J.1    Alonso, E.2    Montequi, I.3    Cocero, M.4
  • 17
    • 0026867521 scopus 로고
    • A theoretically correct mixing rule for cubic equations of state
    • Wong D, Sandler S. A theoretically correct mixing rule for cubic equations of state. AIChE J. 1992; 38: 671-680.
    • (1992) AIChE J. , vol.38 , pp. 671-680
    • Wong, D.1    Sandler, S.2
  • 18
    • 0030184191 scopus 로고    scopus 로고
    • A comparison of various cubic equation of state mixing rules for the simultaneous description of excess enthalpies and vapor-liquid equilibria
    • Orbey H, Sandler SI. A comparison of various cubic equation of state mixing rules for the simultaneous description of excess enthalpies and vapor-liquid equilibria. Fluid Phase Equilib. 1996; 121: 67-83.
    • (1996) Fluid Phase Equilib. , vol.121 , pp. 67-83
    • Orbey, H.1    Sandler, S.I.2
  • 19
    • 0035925280 scopus 로고    scopus 로고
    • Prediction of Excess Enthalpies Using a Gex/EOS Model
    • Escobedo-Alvarado G, Sandler S. Prediction of Excess Enthalpies Using a Gex/EOS Model. Ind Eng Chem Res. 2001; 40: 1261-1270.
    • (2001) Ind Eng Chem Res. , vol.40 , pp. 1261-1270
    • Escobedo-Alvarado, G.1    Sandler, S.2
  • 20
    • 84984084157 scopus 로고
    • Local compositions in thermodynamic excess functions for liquid mixtures
    • Renon H, Prausnitz J. Local compositions in thermodynamic excess functions for liquid mixtures. AIChE J. 1968; 14: 135-144.
    • (1968) AIChE J. , vol.14 , pp. 135-144
    • Renon, H.1    Prausnitz, J.2
  • 22
    • 0038454584 scopus 로고    scopus 로고
    • A unified treatment of general fluid thermodynamics and its application to a preconditioning scheme
    • Meng H, Yang V. A unified treatment of general fluid thermodynamics and its application to a preconditioning scheme. J Comput Phys. 2003; 189: 277-304.
    • (2003) J Comput Phys. , vol.189 , pp. 277-304
    • Meng, H.1    Yang, V.2
  • 24
    • 0029277647 scopus 로고
    • A new k-ε{lunate} eddy viscosity model for high Reynolds number turbulent flows
    • Shih T, Liou W, Shabbir A, Yang Z. A new k-ε{lunate} eddy viscosity model for high Reynolds number turbulent flows. Comput Fluids. 1995; 24: 227-227.
    • (1995) Comput Fluids. , vol.24 , pp. 227-227
    • Shih, T.1    Liou, W.2    Shabbir, A.3    Yang, Z.4
  • 25
    • 67349284371 scopus 로고    scopus 로고
    • Numerical analysis of high-pressure fluid jets: Application to RTD prediction in supercritical reactors
    • Sierra-Pallares J, Parra-Santos M, García-Serna J, Castro F, Cocero M. Numerical analysis of high-pressure fluid jets: Application to RTD prediction in supercritical reactors. J Supercrit Fluids. 2009; 49: 249-255.
    • (2009) J Supercrit Fluids. , vol.49 , pp. 249-255
    • Sierra-Pallares, J.1    Parra-Santos, M.2    García-Serna, J.3    Castro, F.4    Cocero, M.5
  • 26
    • 0025957656 scopus 로고
    • Fundamentals of crystallization: kinetic effects on particle size distributions and morphology
    • Dirksen J, Ring T. Fundamentals of crystallization: kinetic effects on particle size distributions and morphology. Cheml Eng Sci. 1991; 46: 2389-2427.
    • (1991) Cheml Eng Sci. , vol.46 , pp. 2389-2427
    • Dirksen, J.1    Ring, T.2
  • 28
    • 32444451190 scopus 로고    scopus 로고
    • CFD predictions for chemical processing in a confined impinging-jets reactor
    • Liu Y, Fox R. CFD predictions for chemical processing in a confined impinging-jets reactor. AIChE J. 2006; 52: 731-744.
    • (2006) AIChE J. , vol.52 , pp. 731-744
    • Liu, Y.1    Fox, R.2
  • 29
    • 33947152452 scopus 로고    scopus 로고
    • CFD modelling and scale-up of Confined Impinging Jet Reactors
    • Gavi E, Marchisio D, Barresi A. CFD modelling and scale-up of Confined Impinging Jet Reactors. Chem Eng Sci. 2007; 62: 2228-2241.
    • (2007) Chem Eng Sci. , vol.62 , pp. 2228-2241
    • Gavi, E.1    Marchisio, D.2    Barresi, A.3
  • 31
    • 36148963014 scopus 로고
    • The isotropic turbulent mixer: Part II. Arbitrary Schmidt number
    • Corrsin S. The isotropic turbulent mixer: Part II. Arbitrary Schmidt number. AIChE J. 1964; 10: 870-877.
    • (1964) AIChE J. , vol.10 , pp. 870-877
    • Corrsin, S.1
  • 32
    • 0038625401 scopus 로고    scopus 로고
    • Quadrature method of moments for population-balance equations
    • Marchisio D, Pikturna J, Fox R, Vigil R, Barresi A. Quadrature method of moments for population-balance equations. AIChE J. 2003; 49: 1266-1276.
    • (2003) AIChE J. , vol.49 , pp. 1266-1276
    • Marchisio, D.1    Pikturna, J.2    Fox, R.3    Vigil, R.4    Barresi, A.5
  • 33
    • 0031214085 scopus 로고    scopus 로고
    • Description of aerosol dynamics by the quadrature method of moments
    • McGraw R. Description of aerosol dynamics by the quadrature method of moments. Aerosol Sci Technol. 1997; 27: 255-265.
    • (1997) Aerosol Sci Technol. , vol.27 , pp. 255-265
    • McGraw, R.1
  • 34
    • 0027213325 scopus 로고
    • Application of supercritical fluids for the production of sustained delivery devices
    • Debenedetti P, Tom J, Sang-Do Y, Gio-Bin L. Application of supercritical fluids for the production of sustained delivery devices. J Controlled Release. 1993; 24: 27-44.
    • (1993) J Controlled Release. , vol.24 , pp. 27-44
    • Debenedetti, P.1    Tom, J.2    Sang-Do, Y.3    Gio-Bin, L.4
  • 35
    • 0026239830 scopus 로고
    • Molecular thermodynamics of solubilities in gas antisolvent crystallization
    • Dixon D, Johnston K. Molecular thermodynamics of solubilities in gas antisolvent crystallization. AIChE J. 1991; 37: 1441-1449.
    • (1991) AIChE J. , vol.37 , pp. 1441-1449
    • Dixon, D.1    Johnston, K.2
  • 37
    • 84855509934 scopus 로고    scopus 로고
    • Investigation of turbulent precipitation of nanoparticles in a confined impinging-jets reactor. Ph.D. thesis, Politecnico di Torino (Italy). Dipartimento di Scienza Materiali e Ingegnieria Chimica.
    • Gavi E. Investigation of turbulent precipitation of nanoparticles in a confined impinging-jets reactor. Ph.D. thesis, Politecnico di Torino (Italy). Dipartimento di Scienza Materiali e Ingegnieria Chimica. 2009.
    • (2009)
    • Gavi, E.1
  • 39
    • 0019025801 scopus 로고
    • Mass transfer from small particles suspended in turbulent fluid
    • Batchelor G. Mass transfer from small particles suspended in turbulent fluid. J Fluid Mechs. 1980; 98: 609-623.
    • (1980) J Fluid Mechs. , vol.98 , pp. 609-623
    • Batchelor, G.1
  • 40
    • 0024876879 scopus 로고
    • Mass transfer to microparticles in agitated systems
    • Armenante P, Kirwan D. Mass transfer to microparticles in agitated systems. Chem Eng Sci. 1989; 44: 2781-2796.
    • (1989) Chem Eng Sci. , vol.44 , pp. 2781-2796
    • Armenante, P.1    Kirwan, D.2
  • 41
    • 0023999808 scopus 로고
    • Generalized multiparameter correlation for nonpolar and polar fluid transport properties
    • Chung T, Ajlan M, Lee L, Starling K. Generalized multiparameter correlation for nonpolar and polar fluid transport properties. Ind Eng Chem Res. 1988; 27: 671-679.
    • (1988) Ind Eng Chem Res. , vol.27 , pp. 671-679
    • Chung, T.1    Ajlan, M.2    Lee, L.3    Starling, K.4
  • 42
    • 0008601195 scopus 로고    scopus 로고
    • New equation for infinite-dilution diffusion coefficients in supercritical and high-temperature liquid solvents
    • He C, Yu Y. New equation for infinite-dilution diffusion coefficients in supercritical and high-temperature liquid solvents. Ind Eng Chem Res. 1998; 37: 3793-3798.
    • (1998) Ind Eng Chem Res. , vol.37 , pp. 3793-3798
    • He, C.1    Yu, Y.2
  • 44
    • 27444438177 scopus 로고    scopus 로고
    • Supercritical anti solvent precipitation of lycopene:: Effect of the operating parameters
    • Miguel F, Martin A, Gamse T, Cocero M. Supercritical anti solvent precipitation of lycopene:: Effect of the operating parameters. J Supercrit Fluids. 2006; 36: 225-235.
    • (2006) J Supercrit Fluids. , vol.36 , pp. 225-235
    • Miguel, F.1    Martin, A.2    Gamse, T.3    Cocero, M.4
  • 45
    • 33947381045 scopus 로고    scopus 로고
    • Co-precipitation of carotenoids and bio-polymers with the supercritical anti-solvent process
    • Martin A, Mattea F, Gutierrez L, Miguel F, Cocero M. Co-precipitation of carotenoids and bio-polymers with the supercritical anti-solvent process. J Supercrit Fluids. 2007; 41: 138-147.
    • (2007) J Supercrit Fluids. , vol.41 , pp. 138-147
    • Martin, A.1    Mattea, F.2    Gutierrez, L.3    Miguel, F.4    Cocero, M.5
  • 46
    • 44949194011 scopus 로고    scopus 로고
    • Precipitation of lutein and co-precipitation of lutein and poly-lactic acid with the supercritical anti-solvent process
    • Miguel F, Martin A, Mattea F, Cocero M. Precipitation of lutein and co-precipitation of lutein and poly-lactic acid with the supercritical anti-solvent process. Chem Eng Process: Process Intensification. 2008; 47: 1594-1602.
    • (2008) Chem Eng Process: Process Intensification. , vol.47 , pp. 1594-1602
    • Miguel, F.1    Martin, A.2    Mattea, F.3    Cocero, M.4
  • 47
    • 0036558090 scopus 로고    scopus 로고
    • High-Pressure Vapor-Liquid Equilibrium for the Binary Systems Carbon Dioxide+ Dimethyl Sulfoxide and Carbon Dioxide+ Dichloromethane
    • Gonzalez A, Tufeu R, Subra P. High-Pressure Vapor-Liquid Equilibrium for the Binary Systems Carbon Dioxide+ Dimethyl Sulfoxide and Carbon Dioxide+ Dichloromethane. J Chem Eng Data. 2002; 47: 492-495.
    • (2002) J Chem Eng Data. , vol.47 , pp. 492-495
    • Gonzalez, A.1    Tufeu, R.2    Subra, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.