Hepatocyte growth factor attenuates transforming growth factor-β-angiotensin II crosstalk through inhibition of the PTEN/Akt pathway

Hypertension

Volumn 58, Issue 2, 2011, Pages 190-196

  Iekushi, Kazuma ^a   Taniyama, Yoshiaki ^a   Kusunoki, Hiroshi ^a   Azuma, Junya ^a   Sanada, Fumihiro ^a   Okayama, Keita ^a   Koibuchi, Nobutaka ^b   Iwabayashi, Masaaki ^a   Rakugi, Hiromi ^a   Morishita, Ryuichi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

CKD; Fibrosis; PTEN; TGF HGF

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; HYDRALAZINE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SCATTER FACTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY FIBROSIS; KIDNEY INJURY; MESANGIUM CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL PROTECTION; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE; TRANSGENIC MOUSE; WILD TYPE;

ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; HEPATOCYTE GROWTH FACTOR; HUMANS; MESANGIAL CELLS; MICE; MICE, TRANSGENIC; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 80051471866     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.173013     Document Type: Article

References (31)

1. Egido J. Vasoactive hormones and renal sclerosis. Kidney Int. 1996;49: 578-597. (Pubitemid 26051838)
2. Ruiz-Ortega M, Lorenzo O, Suzuki Y, Ruperez M, Egido J. Proinflammatory actions of angiotensins. Curr Opin Nephrol Hypertens. 2001;10: 321-329. (Pubitemid 32424019)
3. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology: XXIII-the angiotensin II receptors. Pharmacol Rev. 2000;52:415-472.
4. Liu Y. Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action. Am J Physiol Renal Physiol. 2004;287: F7-F16. (Pubitemid 38780577)
5. Iekushi K, Taniyama Y, Azuma J, Sanada F, Kusunoki H, Yokoi T, Koibuchi N, Okayama K, Rakugi H, Morishita R. Hepatocyte growth factor attenuates renal fibrosis through tgf-1 suppression by apoptosis of myofibroblasts. J Hypertens. 2010;28:2454-2461.
6. Iekushi K, Taniyama Y, Azuma J, Katsuragi N, Dosaka N, Sanada F, Koibuchi N, Nagao K, Ogihara T, Morishita R. Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin. Hypertension. 2007;49: 1409-1414. (Pubitemid 46809387)
7. Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T, Koibuchi N, Kusunoki H, Aizawa Y, Morishita R. Hepatocyte growth factor, but not vascular endothelial growth factor, attenuates angiotensin ii-induced endothelial progenitor cell senescence. Hypertension. 2009;53: 77-82.
8. Derynck R, Zhang YE. Smad-dependent and smad-independent pathways in tgf-family signalling. Nature. 2003;425:577-584. (Pubitemid 37280136)
9. Moustakas A, Heldin CH. Non-smad TGF-signals. J Cell Sci. 2005; 118:3573-3584.
10. Sulis ML, Parsons R. Pten: from pathology to biology. Trends Cell Biol. 2003;13:478-483. (Pubitemid 37289398)
11. Maehama T, Dixon JE. The tumor suppressor, pten/mmac1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998;273:13375-13378. (Pubitemid 28268370)
12. Border WA, Noble NA. Interactions of transforming growth factor-and angiotensin II in renal fibrosis. Hypertension. 1998;31:181-188.
13. Brooke BS, Habashi JP, Judge DP, Patel N, Loeys B, Dietz HC III. Angiotensin II blockade and aortic-root dilation in marfan's syndrome. N Engl J Med. 2008;358:2787-2795. (Pubitemid 351930853)
14. Lavoie P, Robitaille G, Agharazii M, Ledbetter S, Lebel M, Lariviere R. Neutralization of transforming growth factor-attenuates hypertension and prevents renal injury in uremic rats. J Hypertens. 2005;23: 1895-1903. (Pubitemid 41830430)
15. Lim DS, Lutucuta S, Bachireddy P, Youker K, Evans A, Entman M, Roberts R, Marian AJ. Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy. Circulation. 2001;103:789-791. (Pubitemid 32163874)
16. White ES, Atrasz RG, Hu B, Phan SH, Stambolic V, Mak TW, Hogaboam CM, Flaherty KR, Martinez FJ, Kontos CD, Toews GB. Negative regulation of myofibroblast differentiation by pten (phosphatase and tensin homolog deleted on chromosome 10). Am J Respir Crit Care Med. 2006;173:112-121. (Pubitemid 43069796)
17. Dai CS, Liu YH. Hepatocyte growth factor antagonizes the profibrotic action of TGF-1 in mesangial cells by stabilizing smad transcriptional corepressor tgif. J Am Soc Nephrol. 2004;15:1402-1412.
18. Kim WH, Matsumoto K, Bessho K, Nakamura T. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol. 2005;166: 1017-1028. (Pubitemid 40524427)
19. Mizuno S, Matsumoto K, Li MY, Nakamura T. HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis. FASEB J. 2005;19:580-582. (Pubitemid 40471250)
20. Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Matsumoto K, Nakamura T, Kaneda Y, Horiuchi M, Ogihara T. Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells. Hypertension. 2001;37:581-586. (Pubitemid 32199031)
21. Liu Y, Sun AM, Dworkin LD. Hepatocyte growth factor protects renal epithelial cells from apoptotic cell death. Biochem Biophys Res Commun. 1998;246:821-826. (Pubitemid 28420942)
22. Yo Y, Morishita R, Nakamura S, Tomita N, Yamamoto K, Moriguchi A, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential role of hepatocyte growth factor in the maintenance of renal structure: anti-apoptotic action of hgf on epithelial cells. Kidney Int. 1998;54:1128-1138. (Pubitemid 28449899)
23. Conner EA, Wirth PJ, Kiss A, SantoniRugiu E, Thorgeirsson SS. Growth inhibition and induction of apoptosis by hgf in transformed rat liver epithelial cells. Biochem Bioph Res Co. 1997;236:396-401. (Pubitemid 27373307)
24. Sanada F, Taniyama Y, Iekushi K, Azuma J, Okayama K, Kusunoki H, Koibuchi N, Doi T, Aizawa Y, Morishita R. Negative action of hepatocyte growth factor/c-met system on angiotensin II signaling via liganddependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells. Circ Res. 2009;105:U667-U653.
25. Taniyama Y, Morishita R, Nakagami H, Moriguchi A, Sakonjo H, Shokei K, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters. Circulation. 2000;102:246-252. (Pubitemid 30451784)
26. Nakagami H, Osako MK, Nakagami F, Shimosato T, Minobe N, Moritani T, Shimamura M, Miyake T, Shimizu H, Takeya Y, Morishita R. Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan. Int J Mol Med. 2010;26:477-481.
27. Matsumoto K, Morishita R, Moriguchi A, Tomita N, Yo Y, Nishii T, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats. Hypertension. 1999;34: 279-284. (Pubitemid 29409228)
28. Ernsberger P, Koletsky RJ. Metabolic actions of angiotensin receptor antagonists: PPAR-agonist actions or a class effect? Curr Opin Pharmacol. 2007;7:140-145. (Pubitemid 46404747)
29. Bock JS, Gottlieb SS. Cardiorenal syndrome: new perspectives. Circulation. 2010;121:2592-2600.
30. Yang J, Dai C, Liu Y. Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J Am Soc Nephrol. 2002;13:2464-2477.
31. Nakamura T, Mizuno S, Matsumoto K, Sawa Y, Matsuda H. Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. J Clin Invest. 2000;106:1511-1519. (Pubitemid 32038589)