Cytoplasmic oxysterol-binding proteins: Sterol sensors or transporters?

Chemistry and Physics of Lipids

Volumn 164, Issue 6, 2011, Pages 443-450

  Vihervaara, Terhi ^a   Jansen, Maurice ^b   Uronen, Riikka Liisa ^b   Ohsaki, Yuki ^b   Ikonen, Elina ^b   Olkkonen, Vesa M ^a,b  

^a MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cholesterol; Lipid metabolism; Membrane contact site; OSBP; Oxysterol; Phosphoinositide

Indexed keywords

BINDING PROTEIN; OXYSTEROL BINDING PROTEIN; PHOSPHATIDYLINOSITIDE; STEROL; UNCLASSIFIED DRUG;

CELL MIGRATION; CYTOPLASM; GENE EXPRESSION; HUMAN; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; SENSOR;

ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CYTOPLASM; HUMANS; PHOSPHATIDYLINOSITOLS; RECEPTORS, STEROID; STEROLS;

EUKARYOTA;

EID: 80051471035     PISSN: 00093084     EISSN: 18732941     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2011.03.002     Document Type: Review

References (66)

1. A.M. Anniss, J. Apostolopoulos, S. Dworkin, L.E. Purton, and R.L. Sparrow An oxysterol-binding protein family identified in the mouse DNA Cell Biol. 21 2002 571 580
2. B.P. Atshaves, S.M. Storey, A.L. McIntosh, A.D. Petrescu, O.I. Lyuksyutova, A.S. Greenberg, and F. Schroeder Sterol carrier protein-2 expression modulates protein and lipid composition of lipid droplets J. Biol. Chem. 276 2001 25324 25335
3. C.T. Beh, G. Alfaro, G. Duamel, D.P. Sullivan, M.C. Kersting, S. Dighe, K.G. Kozminski, and A.K. Menon Yeast oxysterol-binding proteins: sterol transporters or regulators of cell polarization? Mol. Cell. Biochem. 326 2009 9 13
4. C.T. Beh, and J. Rine A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution J. Cell Sci. 117 2004 2983 2996 (Pubitemid 39117673)
5. C.T. Beh, L. Cool, J. Phillips, and J. Rine Overlapping functions of the yeast oxysterol-binding protein homologues Genetics 157 2001 1117 1140 (Pubitemid 32225007)
6. F.M. Collier, C.C. Gregorio-King, J. Apostolopoulos, K. Walder, and M.A. Kirkland ORP3 splice variants and their expression in human tissues and hematopoietic cells DNA Cell Biol. 22 2003 1 9 (Pubitemid 36570513)
7. X. Du, J. Kumar, C. Ferguson, T.A. Schulz, Y.S. Ong, W. Hong, W.A. Prinz, R.G. Parton, A.J. Brown, and H. Yang A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking J. Cell Biol. 192 2011 121 135
8. T. Engel, F. Kannenberg, M. Fobker, J.R. Nofer, G. Bode, A. Lueken, G. Assmann, and U. Seedorf Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol FEBS Lett. 581 2007 1673 1680 (Pubitemid 46528932)
9. G.D. Fairn, and C.R. McMaster Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling Cell. Mol. Life Sci. 65 2008 228 236 (Pubitemid 351161484)
10. G.D. Fairn, A.J. Curwin, C.J. Stefan, and C.R. McMaster The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function Proc. Natl. Acad. Sci. U.S.A. 104 2007 15352 15357 (Pubitemid 47502921)
11. G.D. Fairn, and C.R. McMaster The roles of the human lipid-binding proteins ORP9S and ORP10S in vesicular transport Biochem. Cell Biol. 83 2005 631 636 (Pubitemid 41812840)
12. G.D. Fairn, and C.R. McMaster Identification and assessment of the role of a nominal phospholipid binding region of ORP1S (oxysterol-binding-protein- related protein 1 short) in the regulation of vesicular transport Biochem. J. 387 2005 889 896 (Pubitemid 40685726)
13. A. Fraldi, F. Annunziata, A. Lombardi, H.J. Kaiser, D.L. Medina, C. Spampanato, A.O. Fedele, R. Polishchuk, N.C. Sorrentino, K. Simons, and A. Ballabio Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders EMBO J. 29 2010 3607 3620
14. R. Hynynen, M. Suchanek, J. Spandl, N. Bäck, C. Thiele, and V.M. Olkkonen OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids J. Lipid Res. 50 2009 1305 1315
15. R. Hynynen, S. Laitinen, R. Käkelä, K. Tanhuanpaa, S. Lusa, C. Ehnholm, P. Somerharju, E. Ikonen, and V.M. Olkkonen Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis Biochem. J. 390 2005 273 283 (Pubitemid 41192253)
16. E. Ikonen Cellular cholesterol trafficking and compartmentalization Nat. Rev. Mol. Cell Biol. 9 2008 125 138 (Pubitemid 351158918)
17. Y.J. Im, S. Raychaudhuri, W.A. Prinz, and J.H. Hurley Structural mechanism for sterol sensing and transport by OSBP-related proteins Nature 437 2005 154 158 (Pubitemid 41613443)
18. M. Jansen, Y. Ohsaki, L. Rita Rega, R. Bittman, V.M. Olkkonen, and E. Ikonen Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells Traffic 12 2011 218 231
19. N.B. Javitt Oxysterols: novel biologic roles for the 21st century Steroids 73 2008 149 157
20. C.J. Jaworski, E. Moreira, A. Li, R. Lee, and I.R. Rodriguez A family of 12 human genes containing oxysterol-binding domains Genomics 78 2001 185 196 (Pubitemid 34001422)
21. M. Johansson, N. Rocha, W. Zwart, I. Jordens, L. Janssen, C. Kuijl, V.M. Olkkonen, and J. Neefjes Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued ORP1L, and the receptor betalll spectrin J. Cell Biol. 176 2007 459 471
22. M. Johansson, M. Lehto, K. Tanhuanpää, T.L. Cover, and V.M. Olkkonen The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments Mol. Biol. Cell 16 2005 5480 5492 (Pubitemid 41752200)
23. M. Johansson, V. Bocher, M. Lehto, G. Chinetti, E. Kuismanen, C. Ehnholm, B. Staels, and V.M. Olkkonen The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct Mol. Biol. Cell 14 2003 903 915 (Pubitemid 36337441)
24. M. Kawano, K. Kumagai, M. Nishijima, and K. Hanada Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT J. Biol. Chem. 281 2006 30279 30288 (Pubitemid 44537035)
25. H. Kobuna, T. Inoue, M. Shibata, K. Gengyo-Ando, A. Yamamoto, S. Mitani, and H. Arai Multivesicular body formation requires OSBP-related proteins and cholesterol PLoS Genet. 6 2010 e1001055
26. K.G. Kozminski, G. Alfaro, S. Dighe, and C.T. Beh Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae Traffic 2006
27. E. Kvam, and D.S. Goldfarb Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae J. Cell Sci. 117 2004 4959 4968 (Pubitemid 39517512)
28. Y. Lange, J. Ye, and F. Strebel Movement of 25-hydroxycholesterol from the plasma membrane to the rough endoplasmic reticulum in cultured hepatoma cells J. Lipid Res. 36 1995 1092 1097
29. C. Lebrand, M. Corti, H. Goodson, P. Cosson, V. Cavalli, N. Mayran, J. Faure, and J. Gruenberg Late endosome motility depends on lipids via the small GTPase Rab7 EMBO J. 21 2002 1289 1300 (Pubitemid 34246508)
30. M. Lehto, R. Hynynen, K. Karjalainen, E. Kuismanen, K. Hyvärinen, and V.M. Olkkonen Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants Exp. Cell Res. 310 2005 445 462 (Pubitemid 41457347)
31. M. Lehto, S. Laitinen, G. Chinetti, M. Johansson, C. Ehnholm, B. Staels, E. Ikonen, and V.M. Olkkonen The OSBP-related protein family in humans J. Lipid Res. 42 2001 1203 1213 (Pubitemid 32744243)
32. E. Lessmann, M. Ngo, M. Leitges, S. Minguet, N.D. Ridgway, and M. Huber Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation Cell. Signal. 19 2007 384 392 (Pubitemid 44969988)
33. T. Levine, and C. Loewen Inter-organelle membrane contact sites: through a glass, darkly Curr. Opin. Cell Biol. 18 2006 371 378 (Pubitemid 44016060)
34. T.P. Levine, and S. Munro The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes Curr. Biol. 8 1998 729 739 (Pubitemid 28301159)
35. J. Li, A. Mahajan, and M.D. Tsai Ankyrin repeat: a unique motif mediating protein-protein interactions Biochemistry 45 2006 15168 15178 (Pubitemid 46032443)
36. X. Li, M.P. Rivas, M. Fang, J. Marchena, B. Mehrotra, A. Chaudhary, L. Feng, G.D. Prestwich, and V.A. Bankaitis Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex J. Cell Biol. 157 2002 63 77 (Pubitemid 34847830)
37. D. Lingwood, and K. Simons Lipid rafts as a membrane-organizing principle Science 327 2010 46 50
38. C.J. Loewen, A. Roy, and T.P. Levine A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP EMBO J. 22 2003 2025 2035 (Pubitemid 36565528)
39. D.W. Morel, M.E. Edgerton, G.E. Warner, W.J. Johnson, M.C. Phillips, and G.H. Rothblat Comparison of the intracellular metabolism and trafficking of 25-hydroxycholesterol and cholesterol in macrophages J. Lipid Res. 37 1996 2041 2051 (Pubitemid 26307684)
40. M. Ngo, and N.D. Ridgway Oxysterol binding protein-related protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function Mol. Biol. Cell 20 2009 1388 1399
41. M.H. Ngo, T.R. Colbourne, and N.D. Ridgway Functional implications of sterol transport by the oxysterol-binding protein gene family Biochem. J. 429 2010 13 24
42. V.M. Olkkonen New functions for oxysterols and their cellular receptors Lipid Insights 2008 1
43. D. Peretti, N. Dahan, E. Shimoni, K. Hirschberg, and S. Lev Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport Mol. Biol. Cell 19 2008 3871 3884
44. R.J. Perry, and N.D. Ridgway Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein Mol. Biol. Cell 17 2006 2604 2616 (Pubitemid 43825498)
45. S. Raychaudhuri, and W.A. Prinz The diverse functions of oxysterol-binding proteins Annu. Rev. Cell Dev. Biol. 2010
46. S. Raychaudhuri, Y.J. Im, J.H. Hurley, and W.A. Prinz Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides J. Cell Biol. 173 2006 107 119
47. N.D. Ridgway, P.A. Dawson, Y.K. Ho, M.S. Brown, and J.L. Goldstein Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding J. Cell Biol. 116 1992 307 319
48. N. Rocha, C. Kuijl, R. van der Kant, L. Janssen, D. Houben, H. Janssen, W. Zwart, and J. Neefjes Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning J. Cell Biol. 185 2009 1209 1225
49. G.R. Romeo, and A. Kazlauskas Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1 J. Biol. Chem. 283 2008 9595 9605
50. T.A. Schulz, M.G. Choi, S. Raychaudhuri, J.A. Mears, R. Ghirlando, J.E. Hinshaw, and W.A. Prinz Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues J. Cell Biol. 187 2009 889 903
51. C.J. Stefan, A.G. Manford, D. Baird, J. Yamada-Hanff, Y. Mao, and S.D. Emr Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites Cell 144 2011 389 401
52. M. Suchanek, R. Hynynen, G. Wohlfahrt, M. Lehto, M. Johansson, H. Saarinen, A. Radzikowska, C. Thiele, and V.M. Olkkonen The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket Biochem. J. 405 2007 473 480 (Pubitemid 47172044)
53. D.P. Sullivan, H. Ohvo-Rekilä, N.A. Baumann, C.T. Beh, and A.K. Menon Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast Biochem. Soc. Trans. 34 2006 356 358 (Pubitemid 43953985)
54. S.P. Tam, L. Mok, G. Chimini, M. Vasa, and R.G. Deeley ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells Am. J. Physiol. Cell Physiol. 291 2006 C490 502
55. N. Terasaka, N. Wang, L. Yvan-Charvet, and A.R. Tall High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1 Proc. Natl. Acad. Sci. U.S.A. 104 2007 15093 15098 (Pubitemid 47619598)
56. J.J. Theunissen, R.L. Jackson, H.J. Kempen, and R.A. Demel Membrane properties of oxysterols. Interfacial orientation, influence on membrane permeability and redistribution between membranes Biochim. Biophys. Acta 860 1986 66 74
57. M. Vicinanza, G. D'Angelo, A. Di Campli, and M.A. De Matteis Phosphoinositides as regulators of membrane trafficking in health and disease Cell. Mol. Life Sci. 65 2008 2833 2841
58. T. Vihervaara, R.L. Uronen, G. Wohlfahrt, I. Björkhem, E. Ikonen, and V.M. Olkkonen Sterol binding by OSBP-related protein 1L regulates late endosome motility and function Cell. Mol. Life Sci. 68 2011 537 551
59. A. Vila, W. Korytowski, and A.W. Girotti Spontaneous intermembrane transfer of various cholesterol-derived hydroperoxide species: kinetic studies with model membranes and cells Biochemistry 40 2001 14715 14726 (Pubitemid 33111756)
60. C. Wang, L. JeBailey, and N.D. Ridgway Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments Biochem. J. 361 2002 461 472 (Pubitemid 34177815)
61. P.Y. Wang, J. Weng, S. Lee, and R.G. Anderson The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP J. Biol. Chem. 283 2008 8034 8045
62. P.Y. Wang, J. Weng, and R.G. Anderson OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation Science 307 2005 1472 1476 (Pubitemid 40321946)
63. J.P. Wyles, R.J. Perry, and N.D. Ridgway Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization Exp. Cell Res. 313 2007 1426 1437 (Pubitemid 46507448)
64. Y. Xu, Y. Liu, N.D. Ridgway, and C.R. McMaster Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport J. Biol. Chem. 276 2001 18407 18414
65. D. Yan, M.I. Mäyränpää, J. Wong, J. Perttilä, M. Lehto, M. Jauhiainen, P.T. Kovanen, C. Ehnholm, A.J. Brown, and V.M. Olkkonen OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages J. Biol. Chem. 283 2008 332 340
66. D. Yan, M. Jauhiainen, R.B. Hildebrand, K. Willems van Dijk, T.J. Van Berkel, C. Ehnholm, M. Van Eck, and V.M. Olkkonen Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice Arterioscler. Thromb. Vasc. Biol. 27 2007 1618 1624 (Pubitemid 46986118)