Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin

Tsitologiya

Volumn 53, Issue 5, 2011, Pages 404-410

  Filatova, N A ^a   Kirpichnikova, K M ^a   Aksenov, N D ^a   Vakhromova, E A ^a   Gamaley, I A ^a  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

Author keywords

Alpha lipoic acid; Cell cycle; Melatonin; Murine hepatoma; N acetylcysteine; Tumorigenic cells MH22a

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; MELATONIN; THIOCTIC ACID;

ANIMAL; ARTICLE; C3H MOUSE; CELL CYCLE; DRUG EFFECT; DRUG SCREENING; FLOW CYTOMETRY; HUMAN; ISOGRAFT; LIVER CELL CARCINOMA; LIVER TUMOR; MOUSE; PATHOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR CELL CULTURE;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; FLOW CYTOMETRY; HUMANS; INJECTIONS, SUBCUTANEOUS; LIVER NEOPLASMS; MELATONIN; MICE; MICE, INBRED C3H; THIOCTIC ACID; TRANSPLANTATION, ISOGENEIC; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79961241676     PISSN: 00413771     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Russian sources.
2. Russian sources.
3. Russian sources.
4. Russian sources.
5. Russian sources.
6. Russian sources.
7. Russian sources.
8. Russian sources.
9. Russian sources.
10. Russian sources.
11. Russian sources.
12. Russian sources
13. Russian sources.
14. Russian sources.
15. Russian sources.
16. Acuña-Castroviejo D., Escames G., Carozo A., Leon J., Khaldy H., Reiter R.J. 2002. Melatonin, mitochondrial homeostasis and mitochondrial-related diseases. Curr. Topics Med. Chem. 2: 133-152.
17. Aluigi M. G., De Flora S., D'Agostini F., Albini A., Fassina G. 2000. Antiapoptotic and antigenotoxic effects of N-acetylcysteine in human cells of endothelial origin. Anticancer Res. 20: 3183-3187.
18. Anisimov S. V., Popovic N. 2004. Genetic aspects of melatonin biology. Rev. Neurosci. 15: 209-230.
19. Blask D. E., Dauchy R. T., Sauer L. A., Krause J. A. 2004. Melatonin uptake and growth prevention in rat hepatoma 7288CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxyoctadecadienoic acid and the potential role of phytomelatonin. Carcinogenesis. 25: 951-960.
20. Blask D. E., Sauer L. A., Dauchy R. T. 2002. Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr. Top. Med. Chem. 2: 113-132.
21. Dean P. N. 1985. Methods of data analysis in flow cytometry. In: Flow cytometry-instrumentation and data analysis. New York: Acad. Press. 114-124.
22. Dubocovich M. L. 2007. Melatonin receptors: role on sleep and circadian rhythm regulation. Sleep Med. 8. Suppl 3: 34-42.
23. Ferrari G., Yan C. Y., Greene L. A. 1995. N-acetylcysteine (Dand L-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci. 15: 2857-2866.
24. Finkel T., Holbrook N. J. 2000. Oxidants, oxidative stress and the biology of ageing. Nature. 408: 239-247.
25. Gamaley I. A., Klyubin I.V. 1999. Roles of reactive oxygen species: signaling and regulation of cellular functions. Int. Rev. Cytol. 188: 203-255.
26. Han D., Sen C. K., Roy S., Kobayashi M. S., Tritschler H. J., Packer L. 1997. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Amer. J. Physiol. 273: R1771-R1778.
27. Kawakami S., Kageyama Y., Fujii Y., Kihara K., Oshima H. 2001. Inhibitory effect of N-acetylcysteine on invasion and MMP-9 production of T24 human bladder cancer cells. Anticancer Res. 21: P. 213-219.
28. Kelly G. S. 1998. Clinical applications of N-acetylcysteine. Altern. Med. Rev. 3(2): 114-127.
29. Kimura H., Sawada T., Oshima S., Kozawa K., Ishioka T., Kato M. 2005. Toxicity and roles of reactive oxygen species. Curr. Drug Targets Inflamm. Allergy. 4: 489-495.
30. Mikhelson V. M., Gamaley I. A. 2008. Telomere shortening is the sole mechanism of aging. Open Aging J. 2: 30-38.
31. Moini H., Packer L., Saris N. E. 2002. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol. Appl. Pharmacol. 182: 84-90.
32. Moretta L., Moretta A. 2004. Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 23: 255-259.
33. Munoz A. M., Rey P., Soto-Otero R., Guerra M. J., Labandeira- Garcia J. L. 2004. Systemic administration of N-acetylcysteine protects dopaminergic neurons against 6-hydroxydopamine-induced degeneration. J. Neurosci. Res. 76: 551-562.
34. Packer L., Witt E. H., Tritschler H. J. 1995. Alpha-lipoic acid as a biological antioxidant. Free Rad. Biol. Med. 19: 227-250.
35. Parasassi T., Brunelli R., Costa G., De Spirito M., Krasnowsk E. K., Lundeberg T., Pittaluga E., Ursini F. 2010. Thiol redox transitions in cell signaling: a lesson from N-acetylcysteine. Scientific World J. 10: 1192-1202.
36. Rahimi R., Nikfar S., Larijani B., Abdollahi M. 2005. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother. 59: 365-373.
37. Reiter R. J., Tan D., Mayo J. C., Sainz R. M., Leon J., Czarnocki Z. 2003. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim. Pol. 50: 1129-1146.
38. Rivabene R., Viora M., Matarrese P., Rainaldi G., D'Ambrosio A., Malorni W. 1995. N-acetyl-cysteine enhances cell adhesion properties of epithelial and lymphoid cells. Cell Biol. Int. 19: 681-686.
39. Rodriquez C., Mayo J. C., Sainz R. M., Antolin I., Herrera F., Martin V., Reiter R. J. 2004. Regulation of antioxidant enzymes: a significant role for melatonin. J. Pineal Res. 36: 1-9.
40. Roy S., Packer L. 1998. Redox regulation of cell functions by alpha- lipoate: biochemical and molecular aspects. Biofactors. 8: 17-21.
41. Sochman J. 2002. N-acetylcysteine in acute cardiology: 10 years later: what do we know and what would we like to know?! J. Amer. Coll. Cardiol. 39: 1422-1428.
42. Tylicki L., Rutkowski B., Hörl W. H. 2003. Antioxidants: a possible role in kidney protection. Kidney Blood Press Res. 26: 303-314.
43. Whiteman M., Tritschler H., Halliwell B. 1996. Protection against peroxynitrite-dependent tyrosine nitration and a1-antiproteinase inactivation by oxidized and reduced lipoic acid. FEBS Lett. 379: 74-76.
44. Zafarullah M., Li W. Q., Sylvester J., Ahmad M. 2003. Molecular mechanisms of N-acetylcysteine actions. CMLS Cell Mol. Life Sci. 60: 6-20.