Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 31, 2011, Pages 12584-12590

  Falk, Jill E ^a   Chan, Leon Y ^a,b   Amon, Angelika ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDES AND PROTEINS; PROTEIN KINASE KIN4; PROTEIN LTE1; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; BUD; DAUGHTER CELL; ENZYME INHIBITION; FEEDBACK SYSTEM; GENE OVEREXPRESSION; LOW TEMPERATURE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; POLLEN MOTHER CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SPINDLE POLE BODY; SPINDLE POSITION CHECKPOINT; YEAST;

BLOTTING, WESTERN; GREEN FLUORESCENT PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; IMMUNOPRECIPITATION; MICROSCOPY, FLUORESCENCE; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCETALES;

EID: 79961239226     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1107784108     Document Type: Article

References (32)

1. Yeh E, Skibbens RV, Cheng JW, Salmon ED, Bloom K (1995) Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae. J Cell Biol 130:687-700.
2. Cheng J, et al. (2008) Centrosome misorientation reduces stem cell division during ageing. Nature 456:599-604.
3. O'Connell CB, Wang YL (2000) Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion. Mol Biol Cell 11:1765-1774.
4. Bardin AJ, Visintin R, Amon A (2000) A mechanism for coupling exit from mitosis to partitioning of the nucleus. Cell 102:21-31.
5. Bloecher A, Venturi GM, Tatchell K (2000) Anaphase spindle position is monitored by the BUB2 checkpoint. Nat Cell Biol 2:556-558.
6. Daum JR, Gomez-Ospina N, Winey M, Burke DJ (2000) The spindle checkpoint of Saccharomyces cerevisiae responds to separable microtubule-dependent events. Curr Biol 10:1375-1378.
7. Pereira G, Höfken T, Grindlay J, Manson C, Schiebel E (2000) The Bub2p spindle checkpoint links nuclear migration with mitotic exit. Mol Cell 6:1-10.
8. Stegmeier F, Amon A (2004) Closing mitosis: The functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet 38:203-232.
9. Maekawa H, Priest C, Lechner J, Pereira G, Schiebel E (2007) The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal. J Cell Biol 179:423-436.
10. Moore JK, Chudalayandi P, Heil-Chapdelaine RA, Cooper JA (2010) The spindle position checkpoint is coordinated by the Elm1 kinase. J Cell Biol 191:493-503.
11. Caydasi AK, et al. (2010) Elm1 kinase activates the spindle position checkpoint kinase Kin4. J Cell Biol 190:975-989.
12. Chan LY, Amon A (2009) The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4. Genes Dev 23:1639-1649.
13. Adames NR, Oberle JR, Cooper JA (2001) The surveillance mechanism of the spindle position checkpoint in yeast. J Cell Biol 153:159-168.
14. D'Aquino KE, et al. (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 19:223-234.
15. Pereira G, Schiebel E (2005) Kin4 kinase delays mitotic exit in response to spindle alignment defects. Mol Cell 19:209-221.
16. Shirayama M, Matsui Y, Tanaka K, Toh-e A (1994) Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Yeast 10:451-461.
17. Geymonat M, Spanos A, de Bettignies G, Sedgwick SG (2009) Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1. J Cell Biol 187:497-511.
18. Castillon GA, et al. (2003) Septins have a dual role in controlling mitotic exit in budding yeast. Curr Biol 13:654-658.
19. Chan LY, Amon A (2010) Spindle position is coordinated with cell-cycle progression through establishment of mitotic exit-activating and -inhibitory zones. Mol Cell 39:444-454.
20. Jensen S, Johnson AL, Johnston LH, Segal M (2004) Temporal coupling of spindle disassembly and cytokinesis is disrupted by deletion of LTE1 in budding yeast. Cell Cycle 3:817-822.
21. Yoshida S, Ichihashi R, Toh-e A (2003) Ras recruits mitotic exit regulator Lte1 to the bud cortex in budding yeast. J Cell Biol 161:889-897.
22. Geymonat M, Spanos A, Jensen S, Sedgwick SG (2010) Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae. J Cell Biol 191:1097-1112.
23. Farkasovsky M, Küntzel H (1995) Yeast Num1p associates with the mother cell cortex during S/G2 phase and affects microtubular functions. J Cell Biol 131:1003-1014.
24. Audhya A, Emr SD (2002) Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev Cell 2:593-605.
25. Philips J, Herskowitz I (1998) Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae. J Cell Biol 143:375-389.
26. Snyder M (1989) The SPA2 protein of yeast localizes to sites of cell growth. J Cell Biol 108:1419-1429.
27. Höfken T, Schiebel E (2002) A role for cell polarity proteins in mitotic exit. EMBO J 21:4851-4862.
28. García-Cortés JC, McCollum D (2009) Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1. J Cell Biol 186:739-753.
29. Longtine MS, et al. (1998) Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953-961.
30. Kaiser CA, Chen EJ, Losko S (2002) Subcellular fractionation of secretory organelles. Methods Enzymol 351:325-338.
31. Kilmartin JV, Adams AE (1984) Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces. J Cell Biol 98:922-933.
32. Seshan A, Bardin AJ, Amon A (2002) Control of Lte1 localization by cell polarity determinants and Cdc14. Curr Biol 12:2098-2110.