Human L1CAM carrying the missense mutations of the fibronectin-like type III domains is localized in the endoplasmic reticulum and degraded by polyubiquitylation

Journal of Neuroscience Research

Volumn 89, Issue 10, 2011, Pages 1637-1645

  Itoh, Kouichi ^a,b   Fujisaki, Kanako ^a,b   Watanabe, Masatomo ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b OITA UNIVERSITY HOSPITAL   (Japan)

Author keywords

ERAD; Human disease; L1CAM; Missense mutation; Ubiquitin

Indexed keywords

1 DEOXYMANNONOJIRIMYCIN; CASTANOSPERMINE; FIBRONECTIN; MANNOSE OLIGOSACCHARIDE; NERVE CELL ADHESION MOLECULE L1; PLASMID DNA; PROTEASOME;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CELL CULTURE; CONFOCAL LASER MICROSCOPY; DEGLYCOSYLATION; ENDOPLASMIC RETICULUM; GENE CONSTRUCT; GLYCOSYLATION; HUMAN; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MISSENSE MUTATION; MOLECULAR WEIGHT; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SITE DIRECTED MUTAGENESIS; TRANSIENT TRANSFECTION; UBIQUITINATION;

ANIMALS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; FIBRONECTINS; HUMANS; INTRACELLULAR SPACE; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NEURAL CELL ADHESION MOLECULE L1; NEUROBLASTOMA; NEURONS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; UBIQUITINATION;

EID: 79961208828     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22695     Document Type: Article

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