ADH1 expression inversely correlates with CDR1 and CDR2 in Candida albicans from chronic oral candidosis in APECED (APS-I) patients

FEMS Yeast Research

Volumn 11, Issue 6, 2011, Pages 494-498

  Siikala, Emilia ^a,b,c   Bowyer, Paul ^d   Richardson, Malcolm ^e   Saxen, Harri ^f   Sanglard, Dominique ^b   Rautemaa, Riina ^a,c,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^f HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Acetaldehyde; ADH1; CDR1; CDR2; Resistance

Indexed keywords

ACETALDEHYDE; ADH1 PROTEIN; ALCOHOL; CDR1 PROTEIN; CDR2 PROTEIN; FUNGAL PROTEIN; PYRROLE; UNCLASSIFIED DRUG;

ANTIFUNGAL RESISTANCE; ARTICLE; AUTOIMMUNE POLYENDOCRINOPATHY; CANDIDA ALBICANS; CANDIDIASIS; CARBON METABOLISM; CARCINOGENICITY; CONTROLLED STUDY; CORRELATIONAL STUDY; DYSTROPHY; FUNGAL METABOLISM; FUNGUS ISOLATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

ACETALDEHYDE; ALCOHOL DEHYDROGENASE; ALCOHOLS; ANTIFUNGAL AGENTS; AZOLES; CANDIDA ALBICANS; CANDIDIASIS, ORAL; CARCINOGENS; CHRONIC DISEASE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; POLYENDOCRINOPATHIES, AUTOIMMUNE;

CANDIDA ALBICANS;

EID: 79961208461     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2011.00739.x     Document Type: Article

References (16)

1. Arendrup M, Lundgren B, Jensen IM, Hansen BS & Frimodt-Møller N (2001) Comparison of Etest and a tablet diffusion test with the NCCLS broth microdilution method for fluconazole and amphotericin B susceptibility testing of Candida isolates. J Antimicrob Chemoth 47: 521-526.
2. Banerjee D, Martin N, Nandi S, Shukla S, Dominiquez A, Mukhopadhyay G & Prasad R (2007) A genome-wide steroid response study of the major human fungal pathogen Candida albicans. Mycopathologia 164: 1-17.
3. Bertram G, Swoboda RK, Gooday GW, Gow NAR & Brown AJP (1996) Structure and regulation of the Candida albicansADH1 gene encoding an immunogenic alcohol dehydrogenase. Yeast 12: 115-127.
4. Chandra J, Kuhn DM, Mukherjee PK, Hoyer LL, McCormick T & Ghannoum MA (2001) Biofilm formation by the fungal pathogen Candida albicans- development, architecture and drug resistance. J Bacteriol 183: 5385-5394.
5. De Monte S, d'Ovidio F, Danø S & Sørensen PG (2007) Dynamical quorum sensing: population density encoded in cellular dynamics. P Natl Acad Sci USA 104: 18377-18381.
6. Husebye ES, Perheentupa J, Rautemaa R & Kämpe O (2009) Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J Intern Med 265: 514-529 (review).
7. Mukherjee PK, Mohamed S, Chandra J et al. (2006) Alcohol dehydrogenase restricts the ability of the pathogen Candida albicans to form biofilm on catheter surfaces through an ethanol-based mechanism. Infect Immun 74: 3804-3816.
8. National Committee for Clinical Laboratory Standards (2002) Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts - Second Edition: Approved Standard M27-A2. NCCLS, Wayne, PA.
9. Rautemaa R, Hietanen J, Niissalo S, Pirinen S & Perheentupa J (2007a) Oral and oesophageal squamous cell carcinoma - a complication or component of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, APS-I). Oral Oncol 43: 607-613.
10. Rautemaa R, Richardson M, Pfaller M, Koukila-Kähkölä P, Perheentupa J & Saxén H (2007b) Decreased susceptibility of Candida albicans to azole antifungals: a complication of long-term treatment in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients. J Antimicrob Chemoth 60: 889-892.
11. Sanglard D, Kuchler K, Ischer F, Pagani J-L, Monod M & Bille J (1995) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Ch 39: 2378-2386.
12. Sanglard D, Ischer F, Monod M & Bille J (1997) Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143: 405-416.
13. Secretan B, Straif K, Baan R et al. (2009) A review of human carcinogens - Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 10: 1033-1034.
14. Siikala E, Richardson M, Pfaller MA, Diekema DJ, Messer SA, Perheentupa J, Saxén H & Rautemaa R (2009) Candida albicans isolates from APECED patients show decreased susceptibility to miconazole. Int J Antimicrob Ag 34: 607-609.
15. Siikala E, Rautemaa R, Richardson M, Saxén H, Bowyer P & Sanglard D (2010) Persistent Candida albicans colonization and molecular mechanisms of azole resistance in APECED. J Antimicrob Chemoth 65: 2505-2513.
16. Uittamo J, Siikala E, Kaihovaara P, Salaspuro M & Rautemaa R (2009) Chronic candidosis and oral cancer in APECED-patients: production of carcinogenic acetaldehyde from glucose and ethanol by Candida albicans. Int J Cancer 124: 754-756.