DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71

Cell Research

Volumn 21, Issue 8, 2011, Pages 1271-1275

  Xie, Shiqi ^a   Wang, Kai ^a   Yu, Wenjing ^a   Lu, Wei ^a,h   Xu, Ke ^a   Wang, Jianwei ^b   Ye, Bin ^c   Schwarz, Wolfgang ^d,e,f   Jin, Qi ^b   Sun, Bing ^a,g  

^a INSTITUTE PASTEUR OF SHANGHAI   (China)

^b INSTITUTE OF PATHOGEN BIOLOGY   (China)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^e MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^f Shanghai Research Center for Acupuncture and Meridians   (China)

^g INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^h NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CHLORIDE CHANNEL; SODIUM CHLORIDE; VIRUS PROTEIN;

ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENTEROVIRUS; GENETICS; GOLGI COMPLEX; HUMAN; LETTER; METABOLISM; OOCYST; PATCH CLAMP; VIRUS REPLICATION; XENOPUS;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANIMALS; CHLORIDE CHANNELS; ENTEROVIRUS A, HUMAN; GOLGI APPARATUS; HUMANS; OOCYSTS; PATCH-CLAMP TECHNIQUES; SODIUM CHLORIDE; VIRAL PROTEINS; VIRUS REPLICATION; XENOPUS;

HUMAN ENTEROVIRUS 71;

EID: 79961207692     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.112     Document Type: Letter

References (15)

1. Weng KF, Chen LL, Huang PN, Shih SR. Neural pathogenesis of enterovirus 71 infection. Microbes Infect 2010; 12:505-510.
2. Carrasco L. Modification of membrane permeability by animal viruses. Adv Virus Res 1995; 45:61-112.
3. Gonzalez ME, Carrasco L. Viroporins. FEBS Lett 2003; 552:28-34.
4. Fischer WB, Kruger J. Viral channel-forming proteins. Int Rev Cell Mol Biol 2009; 275:35-63.
5. Wang K, Xie S, Sun B. Viral proteins function as ion channels. Biochim Biophys Acta 2011; 1808:510-515.
6. Doedens JR, Kirkegaard K. Inhibition of cellular protein secretion by poliovirus proteins 2B and 3A. EMBO J 1995; 14:894-907.
7. van Kuppeveld FJ, Melchers WJ, Kirkgaard K, Doedens JR. Structure-function analysis of coxsackie B3 virus protein 2B. Virology 1997; 227:111-118.
8. van Kuppeveld FJ, Hoenderop JG, Smeets RL, et al. Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release. EMBO J 1997; 16:3519-3532.
9. de Jong AS, Melchers WJ, Glaudemans DH, Willems PH, van Kuppeveld FJ. Mutational analysis of different regions in the coxsackievirus 2B protein: Requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication. J Biol Chem 2004; 279:19924-19935.
10. de Jong AS, Wessels E, Dijkman HB, et al. Determinants for membrane association and permeabilization of the coxsackievirus 2B protein and the identification of the Golgi complex as the target organelle. J Biol Chem 2003; 278:1012-1021.
11. Suhy DA, Giddings TH, Kirkegaard K. Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: An autophagy-like origin for virus-induced vesicles. J Virol 2000; 74:8953-8965.
12. Nordeen MH, Jones SM, Howell KE, Caldwell JH. GOLAC: An endogenous anion channel of the Golgi complex. Biophys J 2000; 78:2918-2928.
13. Van Baelen K, Dode L, Vanoevelen J, et al. The Ca2+/Mn2+ pumps in the Golgi apparatus. Biochim Biophys Acta 2004; 1742:103-112.
14. Madan V, Castello A, Carrasco L. Viroporins from RNA viruses induce caspase-dependent apoptosis. Cell Microbiol 2008; 10:437-451.
15. Jessen F, Sjoholm C, Hoffmann EK. Identification of the anion exchange protein of Ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4'-diisothiocyano-2,2'-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with 3HDIDS. J Membr Biol 1986; 92:195-205.