Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats

Mechanisms of Ageing and Development

Volumn 132, Issue 6-7, 2011, Pages 298-304

  Pinto, Vanda ^a   Amaral, João ^a   Silva, Elisabete ^a   Simão, Sónia ^a   Cabral, José Miguel ^a   Afonso, Joana ^a   Serrão, Maria Paula ^a   Gomes, Pedro ^a   Pinho, Maria João ^a   Soares da Silva, Patrício ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Aging; Amino acid transporters; Hypertension; Neurohumoral activity; Renal dopaminergic system

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 4F2 HEAVY CHAIN PROTEIN; ALDOSTERONE; AMINO ACID TRANSPORTER; DOPAMINE; L TYPE AMINO ACID TRANSPORTER 1; L TYPE AMINO ACID TRANSPORTER 2; LEVODOPA; NORADRENALIN; PROTEIN ASCT2; SODIUM ION; UNCLASSIFIED DRUG;

AGING; ALDOSTERONE BLOOD LEVEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; DIASTOLIC BLOOD PRESSURE; DOPAMINERGIC ACTIVITY; DOPAMINERGIC SYSTEM; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; NORADRENALIN URINE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPECIES DIFFERENTIATION; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; UPREGULATION; WISTAR KYOTO RAT;

3,4-DIHYDROXYPHENYLACETIC ACID; AGING; AMINO ACID TRANSPORT SYSTEM ASC; AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; ANTIGENS, CD98 LIGHT CHAINS; DOPAMINE; KIDNEY CORTEX; MALE; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

RATTUS;

EID: 79961207610     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2011.06.003     Document Type: Article

References (49)

1. Alvelos M., Ferreira A., Bettencourt P., Serrao P., Pestana M., Cerqueira-Gomes M., Soares-da-Silva P. The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure. Eur. J. Heart Fail. 2004, 6:593-599.
2. Aperia A., Bertorello A., Seri I. Dopamine causes inhibition of Na+-K+-ATPase activity in rat proximal convoluted tubule segments. Am. J. Physiol. 1987, 252:F39-F45.
3. Aperia A.C. Intrarenal dopamine: a key signal in the interactive regulation of sodium metabolism. Annu. Rev. Physiol. 2000, 62:621-647.
4. Armando I., Nowicki S., Aguirre J., Barontini M. A decreased tubular uptake of dopa results in defective renal dopamine production in aged rats. Am. J. Physiol. 1995, 268:F1087-F1092.
5. Broer S. Amino acid transport across mammalian intestinal and renal epithelia. Physiol. Rev. 2008, 88:249-286.
6. Chamiot-Clerc P., Renaud J.F., Safar M.E. Pulse pressure, aortic reactivity, and endothelium dysfunction in old hypertensive rats. Hypertension 2001, 37:313-321.
7. Christensen H.N. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev. 1990, 70:43-77.
8. Chromy V., Rozkosna K., Sedlak P. Determination of serum creatinine by Jaffe method and how to calibrate to eliminate matrix interference problems. Clin. Chem. Lab. Med. 2008, 46:1127-1133.
9. Felder C.C., Campbell T., Albrecht F., Jose P.A. Dopamine inhibits Na(+)-H+ exchanger activity in renal BBMV by stimulation of adenylate cyclase. Am. J. Physiol. 1990, 259:F297-F303.
10. Felder R.A., Jose P.A. Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity. Nat. Clin. Pract. Nephrol. 2006, 2:637-650.
11. Ferreira A., Bettencourt P., Pestana M., Correia F., Serrao P., Martins L., Cerqueira-Gomes M., Soares-da-Silva P. Heart failure, aging, and renal synthesis of dopamine. Am. J. Kidney Dis. 2001, 38:502-509.
12. Ferreira A., Bettencourt P., Pimenta J., Frioes F., Pestana M., Soares-da-Silva P., Cerqueira-Gomes M. The renal dopaminergic system, neurohumoral activation, and sodium handling in heart failure. Am. Heart J. 2002, 143:391-397.
13. Fischer M.J., O'Hare A.M. Epidemiology of hypertension in the elderly with chronic kidney disease. Adv. Chronic Kidney Dis. 2010, 17:329-340.
14. Gildea J.J. Dopamine and angiotensin as renal counterregulatory systems controlling sodium balance. Curr. Opin. Nephrol. Hypertens. 2009, 18:28-32.
15. Gomes P., Soares-da-Silva P. Dopamine. Cardiovascular Hormone Systems: From Molecular Mechanisms to Novel Therapeutics 2008, 251-293. Wiley-VCH, Weinheim. M. Baden (Ed.).
16. Herlitz H., Lundin S., Henning M., Aurell M., Karlberg B.E., Berglund G. Hormonal pattern during development of hypertension in spontaneously hypertensive rats (SHR). Clin. Exp. Hypertens. A 1982, 4:915-935.
17. Jose P.A., Eisner G.M., Felder R.A. Dopamine receptor-coupling defect in hypertension. Curr. Hypertens. Rep. 2002, 4:237-244.
18. Jose P.A., Eisner G.M., Felder R.A. Dopamine and the kidney: a role in hypertension?. Curr. Opin. Nephrol. Hypertens. 2003, 12:189-194.
19. Jose P.A., Raymond J.R., Bates M.D., Aperia A., Felder R.A., Carey R.M. The renal dopamine receptors. J. Am. Soc. Nephrol. 1992, 2:1265-1278.
20. Jose P.A., Soares-da-Silva P., Eisner G.M., Felder R.A. Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation. Biochim. Biophys. Acta 2010, 1802:1259-1267.
21. Kansra V., Hussain T., Lokhandwala M.F. Alterations in dopamine DA1 receptor and G proteins in renal proximal tubules of old rats. Am. J. Physiol. 1997, 273:F53-F59.
22. Komori T., Habuchi Y., Inoue H., Sakai T., Suzuki K., Ohtsuka K., Tanaka H., Fujita N., Yoshimura M. Application of urinary free dopamine as a marker of renal function, and comparison with other renal marker. Rinsho Byori 1997, 45:679-684.
23. Kuchel O., Racz K., Debinski W., Falardeau P., Buu N.T. Contrasting dopaminergic patterns in two forms of genetic hypertension. Clin. Exp. Hypertens. 1987, 9:987-1008.
24. Lehmann M., Spori U., Keul J. Excretion of free dopamine, noradrenaline and adrenaline in 190 males in relation to age and blood pressure. Klin. Wochenschr. 1985, 63:264-271.
25. Lokhandwala M.F., Amenta F. Anatomical distribution and function of dopamine receptors in the kidney. FASEB J. 1991, 5:3023-3030.
26. Melk A., Mansfield E.S., Hsieh S.C., Hernandez-Boussard T., Grimm P., Rayner D.C., Halloran P.F., Sarwal M.M. Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling. Kidney Int. 2005, 68:2667-2679.
27. Nakamura E., Sato M., Yang H., Miyagawa F., Harasaki M., Tomita K., Matsuoka S., Noma A., Iwai K., Minato N. 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J. Biol. Chem. 1999, 274:3009-3016.
28. Nicolau G.Y., Haus E., Lakatua D., Sackett-Lundeen L., Bogdan C., Plinga L., Petrescu E., Ungureanu E., Robu E. Differences in the circadian rhythm parameters of urinary free epinephrine, norepinephrine and dopamine between children and elderly subjects. Endocrinologie 1985, 23:189-199.
29. Pestana M., Soares-da-Silva P. The renal handling of dopamine originating from l-dopa and gamma-glutamyl-l-dopa. Br. J. Pharmacol. 1994, 112:417-422.
30. Pineda M., Fernandez E., Torrents D., Estevez R., Lopez C., Camps M., Lloberas J., Zorzano A., Palacin M. Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an l-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J. Biol. Chem. 1999, 274:19738-19744.
31. Pinho M., Amaral J., Pinto V., Serrão M., Soares-da-Silva P. Regulation of renal LAT2 and 4F2hc expression by aldosterone. J. Epithelial Biol. Pharmacol. 2009, 2:36-43.
32. Pinho M.J., Serrao M.P., Gomes P., Hopfer U., Jose P.A., Soares-da-Silva P. Over-expression of renal LAT1 and LAT2 and enhanced l-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int. 2004, 66:216-226.
33. Pinho M.J., Serrao M.P., Soares-da-Silva P. High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats. Am. J. Physiol. Renal Physiol. 2007, 292:F1452-F1463.
34. Racz K., Kuchel O., Buu N.T., Tenneson S. Peripheral dopamine synthesis and metabolism in spontaneously hypertensive rats. Circ. Res. 1985, 57:889-897.
35. Sanada H., Jose P.A., Hazen-Martin D., Yu P.Y., Xu J., Bruns D.E., Phipps J., Carey R.M., Felder R.A. Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension. Hypertension 1999, 33:1036-1042.
36. Silbernagl S. Renal transport of amino acids. Klin. Wochenschr. 1979, 57:1009-1019.
37. Soares-da-Silva P., Fernandes M.H. A study on the renal synthesis of dopamine in aged rats. Acta Physiol. Scand. 1991, 143:287-293.
38. Soares-da-Silva P., Fernandes M.H., Pinto-do O.P. Cell inward transport of l-DOPA and 3-O-methyl-l-DOPA in rat renal tubules. Br. J. Pharmacol. 1994, 112:611-615.
39. Soares-da-Silva P., Pestana M., Fernandes M.H. Involvement of tubular sodium in the formation of dopamine in the human renal cortex. J. Am. Soc. Nephrol. 1993, 3:1591-1599.
40. Soares-da-Silva P., Serrao M.P. High- and low-affinity transport of l-leucine and l-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells. Am. J. Physiol. Renal Physiol. 2004, 287:F252-F261.
41. Soares-da-Silva P., Vieira-Coelho M.A. Nonneuronal dopamine. Catecholamines. Bridging Basic Science with Clinical Medicine 1998, 866-869. Academic Press, San Diego. D.S. Goldstein, G. Eisenhofer, R. McCarty (Eds.).
42. Susic D., Nunez E., Hosoya K., Frohlich E.D. Coronary hemodynamics in aging spontaneously hypertensive and normotensive Wistar Kyoto rats. J. Hypertens. 1998, 16:231-237.
43. Susic D., Varagic J., Frohlich E.D. Isolated systolic hypertension in elderly WKY is reversed with l-arginine and ACE inhibition. Hypertension 2001, 38:1422-1426.
44. Thomas W., Dooley R., Harvey B.J. Aldosterone as a renal growth factor. Steroids 2010, 75:550-554.
45. Vieira-Coelho M.A., Hussain T., Kansra V., Serrao M.P., Guimaraes J.T., Pestana M., Soares-da-Silva P., Lokhandwala M.F. Aging, high salt intake, and renal dopaminergic activity in Fischer 344 rats. Hypertension 1999, 34:666-672.
46. White B.H., Sidhu A. Increased oxidative stress in renal proximal tubules of the spontaneously hypertensive rat: a mechanism for defective dopamine D1A receptor/G-protein coupling. J. Hypertens. 1998, 16:1659-1665.
47. Yoshimura M., Ikegaki I., Nishimura M., Takahashi H. Role of dopaminergic mechanisms in the kidney for the pathogenesis of hypertension. J. Auton. Pharmacol. 1990, 10(Suppl. 1):s67-s72.
48. Zeng C., Jose P.A. Dopamine receptors: important antihypertensive counterbalance against hypertensive factors. Hypertension 2011, 57:11-17.
49. Zhou X.J., Rakheja D., Yu X., Saxena R., Vaziri N.D., Silva F.G. The aging kidney. Kidney Int. 2008, 74:710-720.