Effects of ethane dimethane sulfonate on the functional structure of the adult rat testis

Archives of Andrology

Volumn 49, Issue 4, 2003, Pages 313-326

  Ariyaratne, S ^a   Kim, I ^a   Mills, N ^b   Mason, I ^c   Mendis Handagama, C ^a,d  

^a UNIVERSITY OF TENNESSEE   (United States)

^b TEXAS WOMAN'S UNIVERSITY   (United States)

^c NHS LOTHIAN   (United Kingdom)

^d Department of Animal Science ^*  (United States)

Author keywords

3 hydroxy steroid dehydrogenase; Androstenedione; Immunocytochemistry; Leydig cells; Stereology; Testosterone

Indexed keywords

ANDROGEN; ETHYLENE GLYCOL DIMESYLATE; LUTEINIZING HORMONE RECEPTOR; TESTOSTERONE;

ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CELL AGING; CELL COUNT; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL RAT; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MACROPHAGE; MESENCHYME CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; TESTIS FUNCTION; TESTOSTERONE RELEASE;

EID: 79961198232     PISSN: 01485016     EISSN: None     Source Type: Journal    
DOI: 10.1080/01485010390204922     Document Type: Article

References (32)

1. Ariyaratne HBS, Mendis-Handagama SMLC (2000): Changes in structure and function of the testis interstitium in Sprague Dawley rats from birth to sexual maturity. Biol Reprod 62:680-690.
2. Ariyaratne HBS, Mendis-Handagama SMLC, Hales DB, Mason JI (2000): Studies on the onset of Leydig precursor cell differentiation in the prepubertal rat testis. Biol Reprod 63:165-171.
3. Ariyaratne HBS, Mason JI, Mendis-Handagama SMLC (2000): Effects of tri-iodothyronineon testicular interstitial cells and androgen secretory capacity of the prepubertal rat. Biol Reprod 63:493-502.
4. Ariyaratne HBS, Mills N, Mason JI, Mendis-Handagama SMLC (2000): Thyroid hormone and Leydig cell regeneration in the adult rat following ethane dimethane sulphonate treatment. Biol Reprod 63:1115-1123.
5. Ariyaratne HBS, Mason JI, Mendis-Handagama SMLC (2000): Effects of thyroid and luteinizing hormones on the onset of precursor cell differentiation into Leydig cells in the prepubertal rat testis. Biol Reprod 63:898-904.
6. Benton L, Shan L-X, Hardy MP (1995): Differentiation of adult Leydig cells. J Steroid Biochem Mol Biol 53:61-68.
7. Bergh A (1987): Treatment with hCG increases the size of Leydig cells and testicular macrophages in unilaterally cryptorchid rat. Int J Androl 10:765-772.
8. Gaytan F, Bellido C, Romero JL, Morales C, Reymundo C, Aguilar E (1994): Decreased number and size and the defective function of testicular macrophages in long-term hypophysectomized rats are reversed by treatment with human gonadotropins. J Endocrinol 140: 399-407.
9. Gaytan F, Bellido C, Morales C, Reymundo C, Aguilar E, van Rooijen N (1994): Selective depletion of testicular macrophages and prevention of Leydig cell repopulation after treatment with ethylene dimethane sulphonate in rats. J Reprod Fertil 101:175-182.
10. Gaytan F, Romero JL, Morales C, Reymundo C, Bellido C, Aguilar E (1995): Response of testicular macrophages to EDS-induced Leydig cell death. Andrologia 27:259-265.
11. Gaytan F, Bellido C, Morales C, Reymundo C, Aguilar E, van Rooijen N (1995): Response to Leydig cell apoptosis in the absence of testicular macrophages. J Reprod Immunol 29:81-94.
12. Hardy MP, Zirkin BR, Ewing LL (1989): Kinetic studies on the development of the adult population of Leydig cells in testes of prepubertal rat. Endocrinology 124:762-770.
13. Hutson JC (1990): Development of testicular macrophages. Biol Reprod 43:885-890.
14. Hutson J (1998): Interactions between testicular macrophages and Leydig cells. J Androl 19: 394-398.
15. Kerr JB, Bartlett JMS, Donachie K (1987): Origin of regenerating Leydig cells in the testis of the adult rat: an ultrastructural, morphometric and hormonal assay study. Cell Tissue Res 249: 367-377.
16. Lording DW, de Kretser DM (1972): Comparative ultrastructural and histochemical studies of the interstitial cells of the rat testis during fetal and postnatal development. J Reprod Fertil 29:261-269.
17. Mendis-Handagama SMLC, Risbridger GP, de Kretser DM (1987): Morphometric analysis of the components of the neonatal and the adult rat testis interstitium. Int J Androl 10:525-534.
18. Mendis-Handagama SMLC, Ewing LL (1990): Sources of error in the estimation of Leydig cell numbers in control and atrophied mammalian testes. J Microscop (Oxford) 159:73-82.
19. Mendis-Handagama SMLC, Kerr JB, de Kretser DM (1990): Experimental cryptorchidism in the adult mouse, II: a hormonal study. J Androl 11:548-554.
20. Mendis-Handagama SMLC, Ariyaratne HBS, Teunissen van Manen KR, Haupt RL (1998): Differentiation of adult Leydig cells in the neonatal rat testis is arrested by hypothyroidism. Biol Reprod 59:351-357.
21. Mendis-Handagama SMLC, Gelber SJ (1995): Signs of aging are apparent in the testis interstitium of Sprague Dawley rats at 6 months of age. Tissue Cell 27:689-699.
22. Morris ID (1996): Leydig cell toxicity. In: The Leydig Cell. Payne AH, Hardy MP, Russell LD (Eds). Vienna, IL: Cache River Press, pp 573-596.
23. O'Leary PC, Jackson AE, de Kretser DM (1986): Evaluation of testicular hCG binding in unilaterally cryptorchid rats following administration of ethane dimethane sulphonate (EDS). Mol Cell Endocrinol 48:51-58.
24. Saez JM (1994): Leydig cells: endocrine, paracrine and autocrine regulation. Endocr Rev 15:574-626.
25. Sterio DC (1984): The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134:127-137.
26. Sylvester SR (1996): Leydig cell Sertoli cell interaction. In: The Leydig Cell, Payne AH, Hardy MP, and Russell LD (Eds). Vienna, IL: Cache River Press, pp 467-476.
27. Teerds KJ (1996): Regeneration of Leydig cells after depletion by EDS: a model for postnatal Leydig cell renewal. In: The Leydig Cell. Payne AH, Hardy MP, Russell LD (Eds), Vienna, IL: Cache River Press, pp 203-220.
28. Teerds KJ, de Boer-Brouwer M, Dorrington JH, Balvers M, Ivell R (1999): Identification of markers for precursor and Leydig cell differentiation in the adult rat testis following ethane dimethyl sulphonate administration. Biol Reprod 60:1437-1445.
29. Tena-Sempere M, Zhang FP, Huhtaniemi I (1994): Persistent expression of a truncated from of the luteinizing hormone receptor messenger ribonucleic acid in the rat testis after selective Leydig cell destruction by ethane dimethane sulphonate. Endocrinology 135:1018-1024.
30. VanDemark NL, Ewing LL (1963): Factors affecting testicular metabolism and function, 1: a simple perfusion technique for short-term maintenance of rabbit testis. J Reprod Fertil 6:1-8.
31. Vreeburg JT, Ooms MP, Rommerts FF, Teerds KJ (1988): Functional properties of developing rat Leydig cells after treatment with ethylene dimethanesulphonate (EDS). J Reprod Fertil 84:63-69.
32. Wang J, Wreford NGM, Lan HY, Atkins R, Hedger MP (1994): Leukocyte populations of the adult rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants. Biol Reprod 51:551-561.