Treatment of refractory Crohn's disease by intensive granulocyte and monocyte adsorption apheresis: A report on two drug refractory cases

Internal Medicine

Volumn 50, Issue 15, 2011, Pages 1591-1593

  Kato, Shingo ^a   Kani, Kazuhito ^a   Takabayashi, Hidehiko ^a   Yamamoto, Ryuichi ^a   Ogawa, Tomonari ^a   Matsuda, Akihiko ^a   Yakabi, Koji ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Crohn's disease; Granulocyte and monocyte adsorption apheresis; Intensive therapy

Indexed keywords

AZATHIOPRINE; C REACTIVE PROTEIN; CORTICOSTEROID; HEMOGLOBIN; INFLIXIMAB; MESALAZINE;

ABDOMINAL DISCOMFORT; ADULT; APHERESIS; ARTICLE; CASE REPORT; CROHN DISEASE; CROHN DISEASE ACTIVITY INDEX; ELEMENTAL DIET; FEMALE; GRANULOCYTE AND MONOCYTE ADSORPTION APHERESIS; HEMATOCHEZIA; HOSPITAL ADMISSION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALE; MEDICAL DECISION MAKING; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; REMISSION; TREATMENT OUTCOME; TREATMENT REFUSAL; WEIGHT REDUCTION;

ADSORPTION; ADULT; ANTIBODIES, MONOCLONAL; AZATHIOPRINE; BLOOD COMPONENT REMOVAL; C-REACTIVE PROTEIN; CROHN DISEASE; DRUG RESISTANCE; FEMALE; GRANULOCYTES; HEMOGLOBINS; HUMANS; MALE; MONOCYTES; REMISSION INDUCTION; YOUNG ADULT;

EID: 79961184114     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.50.5260     Document Type: Article

References (9)

1. Saniabadi AR, Hanai H, Takeuchi K, et al. Adacolomn, an adsorp-tive carrier based granulocyte and monocyte apheresis device for the treatment of inflammatory and refractory disease associated with leukocytes. Ther Apher Dial 7: 48-59, 2003.
2. Matsui T, Nishimura T, Matake H, Ohta T, Sakurai T, Yao T. Granulocyte apheresis for Crohn's disease: a report on seven refractory patients. Am J Gastroenterol 98: 511-512, 2003.
3. Fukuda Y, Matsui T, Suzuki Y, et al. Adsorptive granulocyte and monocyte apheresis for refractory Crohn's disease: an open multi-center prospective study. J Gastroenterology 39: 1158-1164, 2004.
4. Sakuraba A, Motoya S, Watanabe K, et al. An open-label prospective randomized multicenter study shows very rapid remission of ulcerative colitis by intensive granulocyte and monocyte adsorptive apheresis as compared with routine weekly treatment. Am J Gastroenterol 104: 2990-2995, 2009.
5. Tanaka T, Okanobu H, Yoshimi S, et al. In patients with ulcerative colitis, adsorptive depletion of granulocytes and monocytes impacts mucosal level of neutrophils and clinically is most effective in steroid naive patients. Dig Liver Dis 40: 731-736, 2008.
6. ++ monocytes in patients with inflammatory bowel disease. Am J Gastroenterol 103: 1210-1216, 2008.
7. Cohen RD. Treating ulcerative colitis without medications-"Look Mom, No Drugs!". Gastroenterology 128: 235-236, 2005.
8. Sands BE, Sandborn WJ, Feagan B, et al. A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis. Gastroenterology 135: 400-409, 2008.
9. Suzuki Y, Yoshimura N, Fukuda K, Shirai K, Saito Y, Saniabadi AR. A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitis. Dig Dis Sci 51: 2031-2038, 2006.