Importance of a hydrophobic pocket for peptide binding in Lactococcal OppA

Journal of Bacteriology

Volumn 193, Issue 16, 2011, Pages 4254-4256

  Berntsson, Ronnie P A ^a   Thunnissen, Andy Mark W H ^a   Poolman, Bert ^a   Slotboom, Dirk Jan ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL PROTEIN; MEMBRANE PROTEIN; NONAPEPTIDE; OLIGOPEPTIDE BINDING PROTEIN A; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; GRAM POSITIVE BACTERIUM; HYDROGEN BOND; LACTOCOCCUS; PRIORITY JOURNAL; PROTEIN BINDING; REGISTER;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CARRIER PROTEINS; CRYSTALLIZATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTOCOCCUS LACTIS; LIPOPROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 79961160912     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00447-11     Document Type: Article

References (16)

1. Adams, P. D., et al. 2002. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D Biol. Crystallogr. 58:1948-1954.
2. Berntsson, R. P.-A., et al. 2009. The structural basis for peptide selection by the transport receptor OppA. EMBO J. 28:1332-1340.
3. Collaborative Computational Project, number 4. 1994. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50:760-763.
4. Detmers, F., et al. 2000. Combinatorial peptide libraries reveal the ligandbinding mechanism of the oligopeptide receptor OppA of Lactococcus lactis. Proc. Natl. Acad. Sci. U.S.A. 97:12487-12492.
5. Doeven, M. K., R. Abele, R. Tampe, and B. Poolman. 2004. The binding specificity of OppA determines the selectivity of the oligopeptide ATPbinding cassette transporter. J. Biol. Chem. 279:32301-32307.
6. Emsley, P., and K. Cowtan. 2004. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60:2126-2132.
7. Juillard, V., A. Guillot, D. Le Bars, and J. C. Gripon. 1998. Specificity of milk peptide utilization by Lactococcus lactis. Appl. Environ. Microbiol. 64:1230- 1236.
8. Kabsch, W. 2010. XDS. Acta Crystallogr. D Biol. Crystallogr. 66:125-132.
9. Kunji, E. R., et al. 1995. Transport of beta-casein-derived peptides by the oligopeptide transport system is a crucial step in the proteolytic pathway of Lactococcus lactis. J. Biol. Chem. 270:1569-1574.
10. Kunji, E. R. S., et al. 1998. Reconstruction of the proteolytic pathway for use of beta-casein by Lactococcus lactis. Mol. Microbiol. 27:1107-1118.
11. Lanfermeijer, F., F. Detmers, W. Konings, and B. Poolman. 2000. On the binding mechanism of the peptide receptor of the oligopeptide transport system of Lactococcus lactis. EMBO J. 19:3649-3656.
12. McCoy, A., R. Grosse-Kunstleve, L. Storoni, and R. J. Read. 2005. Likelihood-enhanced fast translation functions. Acta Crystallogr. D Biol. Crystallogr. 61:458-464.
13. Murshudov, G., A. Vagin, and E. Dodson. 1997. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53:240-255.
14. Nickitenko, A., S. Trakhanov, and F. Quiocho. 1995. 2 Å resolution structure of DppA, a periplasmic dipeptide transport/chemosensory receptor. Biochemistry 34:16585-16595.
15. Reiter, B., and J. Oram. 1962. Nutritional studies on cheese starters: I. Vitamin and amino acid requirement of single strain starters. J. Dairy Res. 29:63-77.
16. Tame, J., et al. 1994. The structural basis of sequence-independent peptide binding by OppA protein. Science 264:1578-1581.