Immunomodulatory and antitumor activity of Aerva lanata ethanolic extract

Immunopharmacology and Immunotoxicology

Volumn 33, Issue 3, 2011, Pages 423-432

  Siveen, K S ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Bone marrow cellularity; Circulating antibody titer; DLA induced solid tumor; Lymphocyte proliferation; Plaque forming cells

Indexed keywords

AERVA LANATA EXTRACT; ALCOHOL; ALPHA ESTERASE; ANTIBODY; ANTINEOPLASTIC AGENT; CONCANAVALIN A; ESTERASE; IMMUNOMODULATING AGENT; LIPOPOLYSACCHARIDE; PHYTOHEMAGGLUTININ; PLANT EXTRACT; POKEWEED MITOGEN; UNCLASSIFIED DRUG;

AERVA LANATA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASCITES CELL; ASCITES TUMOR; BONE MARROW CELL; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; EHRLICH ASCITES TUMOR CELL; HELA CELL; HEMATOLOGICAL PARAMETERS; IMMUNOMODULATION; LEUKOCYTE COUNT; LYMPHOCYTE TRANSFORMATION; LYMPHOMA CELL; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; ORGAN WEIGHT; PLAQUE FORMING CELL; PRIORITY JOURNAL; SOLID TUMOR; SOLVENT EXTRACTION; SPLEEN CELL; THYMOCYTE;

AMARANTHACEAE; ANIMALS; ANTIBODIES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BONE MARROW CELLS; CARCINOMA, EHRLICH TUMOR; CELL LINE, TUMOR; CELL PROLIFERATION; ETHANOL; HELA CELLS; HUMANS; IMMUNOLOGIC FACTORS; LEUKOCYTES; LYMPHOCYTE ACTIVATION; LYMPHOMA; MALE; MICE; MICE, INBRED BALB C; ORGAN SIZE; PLANT EXTRACTS; PLANTS, MEDICINAL; SPLEEN; THYMUS GLAND;

AERVA; AERVA LANATA; MUS;

EID: 79961144817     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2010.526614     Document Type: Article

References (29)

1. Gabriel, J. What is cancer? In: Gabriel J, editor. Te Biology of Cancer, 2nd ed. Chichester, Hoboken, NJ: John Wiley & Sons, 2007, pp. 3-9.
2. Jemal, A., Siegel, R., Xu, J., Ward, E. Cancer statistics, 2010. CA Cancer J. Clin. 2010, 60, 277-300.
3. Devasagayam, T.P., Sainis, K.B. Immune system and antioxidants, especially those derived from Indian medicinal plants. Indian J. Exp. Biol. 2002, 40, 639-655. (Pubitemid 34604536)
4. Ríhová, B., Kovár, M. Immunogenicity and immunomodulatory properties of HPMA-based polymers. Adv. Drug Deliv. Rev. 2010, 62, 184-191.
5. Cragg, G.M., Newman, D.J., Snader, K.M. Natural products in drug discovery and development. J. Nat. Prod. 1997, 60, 52-60. (Pubitemid 27052102)
6. Sarker SD, Latif Z, Gray AI. Natural products isolation. In: Sarker SD, Latif Z, Gray AI, editors. Natural Products Isolation, 2nd ed. Totowa, NJ: Humana Press, 2005, pp. 1-25.
7. Soundararajan, P., Mahesh, R., Ramesh, T., Begum, V.H. Efect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian J. Exp. Biol. 2006, 44, 981-986. (Pubitemid 46797003)
8. Nevin KG, Vijayammal PL. Efect of Aerva lanata against hepatotoxicity of carbon tetrachloride in rats. Environ. Toxicol. Pharmacol. 2005, 20, 471-477. (Pubitemid 41318061)
9. Nevin, K.G., Vijayammal, P.L. Efect of Aerva lanata on solid tumor induced by DLA cells in mice. Fitoterapia 2003, 74, 578-582. (Pubitemid 36999908)
10. Chowdhury, D., Sayeed, A., Islam, A., Shah Alam Bhuiyan, M., Astaq Mohal Khan, G.R. Antimicrobial activity and cytotoxicity of Aerva lanata. Fitoterapia 2002, 73, 92-94. (Pubitemid 34195541)
11. Shirwaikar, A., Issac, D., Malini, S. Efect of Aerva lanata on cisplatin and gentamicin models of acute renal failure. J. Ethnopharmacol. 2004, 90, 81-86. (Pubitemid 38091690)
12. Sredni, B., Albeck, M., Kazimirsky, G., Shalit, F. Te immunomodulator AS101 administered orally as a chemoprotective and radioprotective agent. Int. J. Immunopharmacol. 1992, 14, 613-619.
13. Manu, K.A., Kuttan, G. Immunomodulatory activities of punarnavine, an alkaloid from Boerhaavia difusa. Immunopharmacol. Immunotoxicol. 2009, 31, 377-387.
14. Hamsa, T.P., Kuttan, G. Ipomoea obscura (L.) enhances the functions of immunological efector cells, inhibits proinfammatory cytokines and nitric oxide production by LPS induced macrophages. Immunopharmacol. Immunotoxicol. 2008, 1-15.
15. Talwar, G.P. Handbook of Practical Immunology. New Delhi. National Book Trust, 1974.
16. Manu, K.A., Kuttan, G. Punarnavine induces apoptosis in B16F-10 melanoma cells by inhibiting NF-kappaB signaling. Asian Pac. J. Cancer Prev. 2009, 10, 1031-1037.
17. Attia, M.A., Weiss, D.W. Immunology of spontaneous mammary carcinomas in mice. V. Acquired tumor resistance and enhancement in strain A mice infected with mammary tumor virus. Cancer Res. 1966, 26, 1787-1800.
18. Guruvayoorappan, C., Kuttan, G. Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pac. J. Cancer Prev. 2007, 8, 27-32.
19. Davis, L., Kuttan, G. Immunomodulatory activity of Withania somnifera. J. Ethnopharmacol. 2000, 71, 193-200. (Pubitemid 30440669)
20. Mathew, S., Kuttan, G. Antioxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J. Exp. Clin. Cancer Res. 1997, 16, 407-411. (Pubitemid 28083542)
21. Sunila, E.S., Kuttan, G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J. Ethnopharmacol. 2004, 90, 339-346. (Pubitemid 38180485)
22. Raphael, T.J., Kuttan, G. Immunomodulatory activity of naturally occurring monoterpenes carvone, limonene, and perillic acid. Immunopharmacol. Immunotoxicol. 2003, 25, 285-294. (Pubitemid 36597423)
23. Tejass, P., Kuttan, G. Immunomodulatory activity of sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine 2007, 14, 538-545. (Pubitemid 47068945)
24. Manesh, C., Kuttan, G. Efect of naturally occurring isothiocyanates on the immune system. Immunopharmacol. Immunotoxicol. 2003, 25, 451-459. (Pubitemid 37204454)
25. Blitstein-Willinger, E., Schulz, G., Diamantstein, T. Changes in thymocyte reactivity to lectins induced by B-cell mitogens of the type of sulphated polyanions. Immunology 1976, 30, 529-535.
26. Kuttan, G., Kuttan, R. Immunomodulatory activity of a peptide isolated from Viscum album extract (NSC 635 089). Immunol. Invest. 1992, 21, 285-296.
27. Vetrichelvan, T., Jegadeesan, M. Anti-diabetic activity of alcoholic extract of Aerva lanata (L.) Juss. ex Schultes in rats. J. Ethnopharmacol. 2002, 80, 103-107. (Pubitemid 34462195)
28. Zapesochnaya, G.G., Pervykh, L.N., Kurkin, V.A. A study of the herb Aerva lanata. III. Alkaloids. Chem. Nat. Compd. 1991, 27, 336-340.
29. Zapesochnaya, G., Kurkin, V., Okhanov, V., Miroshnikov, A. Canthin-6-one and beta-carboline alkaloids from Aerva lanata. Planta Med. 1992, 58, 192-196.