Synthesis, characterization and antimicrobial activity of 2-(2'-substituted - benzylidene - hydrazino -acetyl) - mercapto -5-methyl - 1, 3, 4-thiadiazoles and 2 -[2'- {4 - substituted -aryl - 3 - chloro - 2 - oxo -azetidine} -acetyl-aminomercapto] - 5-methyl - 1, 3, 4 -thiadiazoles

International Journal of Pharma and Bio Sciences

Volumn 1, Issue 2, 2010, Pages

  Dua, Rajiv ^a   Srivastava, S K ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

2 oxo azetidines; 5 Methyl 1,3,4 thiadiazole 2 thiol; Antimicrobial activity; Benzylidenes

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; GRISEOFULVIN; STREPTOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; FUSARIUM OXYSPORUM; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; TRICHODERMA VIRIDE;

EID: 79961131968     PISSN: None     EISSN: 09756299     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. M Mihaela, S Valeriu, P Lenuta, P Marcel, Jacques De and P Cristian, Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety, Molecules, 14: 2621-2631,(2009)
2. NC Desai, AM Bhavsar, MD Shah and AK Saxena, Synthesis and QSAR Studies of Thiosemicarbazides, 1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4- Oxadiazoles Derivatives as Potential Antibacterial Agents, Ind. J. Chem., 47B: 579-585,(2008).
3. A Mohd, A Kumar, I Ali and SA Khan, Synthesis of Pharmaceutically Important 1,3,4 Thiadiazole and Imidazolinone Derivatives as Antimicrobials, India J. Chem, 43B: 1288-1293,(2009).
4. BA Teicher, SD Liu, JT Liu, SA Holden, TS Herman, A Carbonic Anhydrase Inhibitor as a Potential Modulator of Cancer Therapies, Anticancer Res.,13(5A): 1549-56,(1993)
5. R Shashikant, K Prajact, SD Nachiket, AN Sunil, SM Deepak, KP Smita and AV Daithankar, Synthesis and Biological Evaluation of Some 1,3,4-Thiadiazoles, J.Chem. and Pharm. Res., 1(1): 191-198,(2009)
6. RLN Harris and J Huppatz, Synthetic Plant growth regulators, Synthesis of Carboxyphenyl Derivatives of Some Fivemembered Heterocycles, Aus. J.Chem., 30(10): 2225 - 2240,(1977)
7. A Ameya, A Chavan and RP Nandini, Synthesis and Biological Activity of NSubstituted-3-chloro-2-azetidinones, Molecules, 12: 2467-2477,(2007)
8. P Mrunmayee, JK Vilasrao, MK Vithal, Synthesis and Antifungal activity of some Azetidinones, Int.J Chem.Tech. Res., 1(4): 1194-1199, (2009).
9. SK Srivastava, S Srivastava, and SD Srivastava, Synthesis of new carbazolylthiadiazolyl-2-oxo-azetidines, antimicrobial, anticonvulsant and anti-inflammatory agents, Indian J. Chem.,38B: 183-187,(1999).
10. GS Singh and JM Boycie, Synthesis of 2-azetidinones from 2-diazo-1,2-diarylethanones and N-(2-thienylidene) imines as possible Antimicrobial agents, Farmaco II, 60(9):727-730,(2005)
11. DV Wayne, Rosy Sher and RDJ Harry, Carboxy-substituted 2-azetidinones as Cholesterol Absorption Inhibitors, Bioorganic & Medicinal Chemistry Letters, 8(3): 319-322, (1998)
12. C James Sutton et al, Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based Tryptase inhibitors, Bioorganic & Medicinal Chemistry Letters, 12(21):3229-3233,(2002)
13. G S Singh, Recent progress in the Synthesis and Chemistry of Azetidinones, Tetrahedron, 59(39): 7631-7649,(2003)
14. SK Sonwane and SD Srivastava, Synthesis and Biological Significance of 2-amino-4-phenyl-1,3-thiazole derivatives, Proc.Nat Acad. Sci. India, 78A (II): 129-136,(2008).
15. IM Labouta, HM Solana, N.H. Escba, and E El-Chrbini., Biological activity of hydrazine derivatives, Eur. J. Med. Chem., 72: 485-487,(1987).