Alexithymia and tissue inflammation

Psychotherapy and Psychosomatics

Volumn 80, Issue 6, 2011, Pages 359-364

  Honkalampi, Kirsi ^a,b   Lehto, Soili M ^b,c   Koivumaa Honkanen, Heli ^b,d,e   Hintikka, Jukka ^b,c,f   Niskanen, Leo ^b,c   Valkonen Korhonen, Minna ^b,c   Viinamäki, Heimo ^b,c  

^a Kuopio Psychiatric Center   (Finland)

^b Kuopio University Hospital   (Japan)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d UNIVERSITY OF OULU   (Finland)

^e LAPLAND CENTRAL HOSPITAL   (Finland)

^f PÄIJÄT HÄME CENTRAL HOSPITAL   (Finland)

Author keywords

Alexithymia; Depression; Immune system

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6;

ADULT; ALEXITHYMIA; ARTICLE; BECK DEPRESSION INVENTORY; CHRONIC INFLAMMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RATING SCALE; SOFT TISSUE INFLAMMATION; TORONTO ALEXITHYMIA SCALE;

AFFECTIVE SYMPTOMS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CLUSTER ANALYSIS; DEPRESSION; FEMALE; FINLAND; HEALTH SURVEYS; HUMANS; INFLAMMATION; INTERLEUKIN-6; LOGISTIC MODELS; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; REGISTRIES;

EID: 79961116914     PISSN: 00333190     EISSN: 14230348     Source Type: Journal    
DOI: 10.1159/000327583     Document Type: Article

References (37)

1. Segerstrom SC, Miller GE: Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull 2004; 130: 601-630. (Pubitemid 38882638)
2. Kobrosly R, van Wijngaarden E: Associations between immunologic, inflammatory, and oxidative stress markers with severity of depressive symptoms: an analysis of the 2005-2006 National Health and Nutrition Examination Survey. Neurotoxicology 2010; 31: 126-133.
3. Sifneos PE: The prevalence of 'alexithymic' characteristics in psychosomatic patients. Psychother Psychosom 1973; 22: 255-262.
4. Lindholm T, Lehtinen V, Hyyppä MT, Puukka P: Alexithymic features in relation to the dexamethasone suppression test in a Finnish population sample. Am J Psychiatry 1990; 147: 1216-1219. (Pubitemid 20275378)
5. Guilbaud O, Corcos M, Hjalmarsson L, Loas G, Jeammet P: Is there a psychoneuroimmunological pathway between alexithymia and immunity? Immune and physiological correlates of alexithymia. Biomed Pharmacother 2003; 57: 292-295. (Pubitemid 37123100)
6. Pedrosa GF, Nickel M, Ridout N, Schwarz MJ, Schoechlin C, Schmidmaier R: Alexithymia and interleukin variations in somatoform disorder. Neuroimmunomodulation 2007; 14: 235-242. (Pubitemid 351339989)
7. Mandarelli G, Tarsitani L, Ippoliti F, Covotta F, Zerella MP, Mirigliani A, Biondi M: The relationship between alexithymia and circulating cytokine levels in subjects undergoing upper endoscopy. Neuroimmunomodulation 2011; 18: 37-44.
8. de Berardis D, Serroni N, Campanella D, Carano A, Gambi F, Valchera A, Conti C, Sepede G, Scali M, Fulcheri M, Salerno RM, Ferro FM: Alexithymia and its relationships with C-reactive protein and serum lipid levels among drug naïve adult outpatients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1982-1986.
9. Honkalampi K, Hintikka J, Tanskanen A, Lehtonen J, Viinamäki H: Depression is strongly associated with alexithymia in the general population. J Psychosom Res 2000; 48: 99-104. (Pubitemid 30128573)
10. Celikel FC, Kose S, Erkorkmaz U, Sayar K, Cumurcu BE, Cloninger CR: Alexithymia and temperament and character model of personality in patients with major depressive disorder. Compr Psychiatry 2010; 51: 64-70.
11. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL: A metaanalysis of cytokines in major depression. Biol Psychiatry 2010; 67: 446-457.
12. Viinamäki H, Heiskanen T, Lehto SM, Niskanen L, Koivumaa-Honkanen H, Tolmunen T, Honkalampi K, Saharinen T, Haatainen K, Hintikka J: Association of depressive symptoms and metabolic syndrome in men. Acta Psychiatr Scand 2009; 120: 23-29.
13. Lehto SM, Huotari A, Niskanen L, Herzig KH, Tolmunen T, Viinamäki H, Koivumaa-Honkanen H, Honkalampi K, Sinikallio S, Ruotsalainen H, Hintikka J: Serum IL-7 and G-CSF in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34: 846-851.
14. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-571.
15. Bagby RM, Parker JDA, Taylor GJ: The twenty-item Toronto Alexithymia Scale-I: item selection and cross-validation of the factor structure. J Psychosom Res 1994; 38: 23-32.
16. Koivumaa-Honkanen HT, Honkanen R, Vii namäki H, Heikkilä K, Kaprio J, Koskenvuo M: Self-reported life satisfaction and 20-year mortality in healthy Finnish adults. Am J Epidemiol 2000; 152: 983-991.
17. Joukamaa M, Miettunen J, Kokkonen P, Koskinen M, Julkunen J, Kauhanen J, Jokelainen J, Veijola J, Läksy K, Järvelin MR: Psychometric properties of the Finnish 20-item Toronto Alexithymia Scale. Nord J Psychiatry 2001; 55: 123-127. (Pubitemid 32487601)
18. Bagby RM, Taylor GJ: Measurement and validation of the alexithymia construct; in Taylor GJ, Bagby RM, Parker JDA (eds): Disorders of Affect Regulation. Alexithymia in Medical and Psychiatric Illness. Cambridge, Cambridge University Press, 1997, pp 47-66.
19. Cohen J: Statistical Power Analysis for the Behavioral Sciences, ed 2. Hillsdale, Lawrence Erlbaum, 1988.
20. Bjerkeset O, Romild U, Smith GD, Hveem K: The associations of high levels of C-reactive protein with depression and myocardial infarction in 9,258 women and men from the HUNT population study. Psychol Med 2010; 6: 1-8.
21. Imhof A, Froehlich M, Brenner H, Boeing H, Pepys MB, Koenig W: Effect of alcohol consumption on systemic markers of inflammation. Lancet 2001; 357: 763-767. (Pubitemid 32217685)
22. Babyak MA: What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Psychosom Med 2004; 66: 411-421.
23. Gasparyan AY, Stavropoulos-Kalinoglou A, Mikhailidis DP, Toms TE, Douglas KM, Kitas GD: The rationale for comparative studies of accelerated atherosclerosis in rheumatic diseases. Curr Vasc Pharmacol 2010; 8: 437-449.
24. Latkovskis G, Licis N, Kalnins U: C-reactive protein levels and common polymorphisms of the interleukin-1 gene cluster and interleukin-gene in patients with coronary heart disease. Eur J Immunogenet 2004; 31: 207-213. (Pubitemid 39315139)
25. de Gennaro L, Martina M, Curcio G, Ferrara M: The relationship between alexithymia, depression, and sleep complains. Psychiatry Res 2004; 128: 253-258. (Pubitemid 39490845)
26. Surtees PG, Wainwright NW, Boekholdt SM, Luben RN, Wareham NJ, Khaw KT: Major depression, C-reactive protein, and incident ischemic heart disease in healthy men and women. Psychosom Med 2008; 70: 850-855.
27. Schneiderman N, Ironson G, Siegel SD: Stress and health: psychological, behavioural and biological determinants. Annu Rev Clin Psychol 2005; 1: 607-628. (Pubitemid 43843964)
28. Fukunishi I, Sei H, Morita Y, Rahe RH: Sympathetic activity in alexithymics with mother's low care. J Psychosom Res 1999; 46: 579-589. (Pubitemid 29342452)
29. de Timary P, Roy E, Luminet O, Fillée C, Mikolajczak M: Relationship between alexithymia, alexithymia factors and salivary cortisol in men exposed to a social stress test. Psychoneuroendocrinology 2008; 33: 1160-1164.
30. Martin JB, Pihl RO: Influence of alexithymic characteristics on physiological and subjective stress responses in normal individuals. Psychother Psychosom 1986; 45: 66-77.
31. Finset A, Graugaard PK, Holgersen K: Salivary cortisol response after a medical interview: the impact of physician communication behaviour, depressed affect and alexithymia. Patient Educ Couns 2006; 60: 115-124. (Pubitemid 43143305)
32. Declercq F, Vanheule S, Deheegher J: Alexithymia and posttraumatic stress: subscales and symptom clusters. J Clin Psychol 2010; 66: 1-14.
33. Brietzke E, Stertz L, Fernandes BS, Kauer-Sant'anna M, Mascarenhas M, Escosteguy Vargas A, Chies JA, Kapczinski F: Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder. J Affect Disord 2009; 116: 214-217.
34. Dewaraja R, Tanigava T, Araki S, Nakata A, Kawamura N, Ago Y, Sasaki Y: Decreased cytotoxic lymphocyte counts in alexithymia. Psychother Psychosom 1997; 66: 83-86. (Pubitemid 27117333)
35. Guilbaud O, Curt F, Perrin C, Chaouat G, Berthoz S, Dugré-le Birge C, Wallier J, Stebler M, Touitou C, Jeammet P, Corcos M: Decreased immune response in alexithymic women: a cross-sectional study. Biomed Pharmacother 2009; 63: 297-304.
36. Taylor GJ, Bagby RM: New trends in alexithymia research. Psychother Psychosom 2004; 73: 68-77. (Pubitemid 38223749)
37. Taylor GJ: Affects, trauma, and mechanisms of symptom formation: a tribute to John C Nemiah, MD (1918-2009). Psychother Psychosom 2010; 79: 339-349.