Activation of adenosine A2A receptors inhibits neutrophil transuroepithelial migration

Infection and Immunity

Volumn 79, Issue 8, 2011, Pages 3431-3437

  Säve, Susanne ^a   Mohlin, Camilla ^a   Vumma, Ravi ^b   Persson, Katarina ^a,b  

^a LINNAEUS UNIVERSITY   (Sweden)

^b ÖREBRO UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; CD11B ANTIGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B ALPHA; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; PHOSPHOPROTEIN; I KAPPA B; ITGAM PROTEIN, HUMAN; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLADDER EPITHELIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUMINESCENCE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL TRANSUROEPITHELIAL MIGRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSITIONAL BLADDER UROTHELIUM; UROPATHOGENIC ESCHERICHIA COLI; UROTHELIUM; CELL CULTURE; CELL MOTION; ESCHERICHIA COLI; HOST PATHOGEN INTERACTION; IMMUNOLOGY; LEUKOCYTE MIGRATION; METABOLISM; NEUTROPHIL; PATHOGENICITY; PHYSIOLOGY;

ANTIGENS, CD11B; CELL MIGRATION ASSAYS, LEUKOCYTE; CELL MOVEMENT; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FLOW CYTOMETRY; HOST-PATHOGEN INTERACTIONS; HUMANS; I-KAPPA B PROTEINS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-8; NEUTROPHILS; RECEPTOR, ADENOSINE A2A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UROTHELIUM;

EID: 79961106306     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05005-11     Document Type: Article

References (34)

1. Agace, W. W., S. R. Hedges, M. Ceska, and C. Svanborg. 1993. Interleukin-8 and the neutrophil response to mucosal gram-negative infection. J. Clin. Invest. 92:780-785.
2. Agace, W. W., M. Patarroyo, M. Svensson, E. Carlemalm, and C. Svanborg. 1995. Escherichia coli induces transuroepithelial neutrophil migration by an intercellular adhesion molecule-1-dependent mechanism. Infect. Immun. 63: 4054-4062.
3. Brasier, A. R. 2006. The NF-kB regulatory network. Cardiovasc. Toxicol. 6:111-130.
4. Chen, C. C., C. L. Rosenbloom, D. C. Anderson, and A. M. Manning. 1995. Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of IkBα phosphorylation. J. Immunol. 155:3538-3545.
5. Chen, Y., et al. 2006. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science 314:1792-1795.
6. Chen, Y., A. Shukla, S. Namiki, P. A. Insel, and W. G. Junger. 2004. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J. Leukoc. Biol. 76:245-253.
7. Cronstein, B. N. 1994. Adenosine, an endogenous anti-inflammatory agent. J. Appl. Physiol. 76:5-13.
8. Cronstein, B. N., L. Daguma, D. Nichols, A. J. Hutchison, and M. Williams. 1990. The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. J. Clin. Invest. 85:1150-1157.
9. Cronstein, B. N., R. I. Levin, J. Belanoff, G. Weissmann, and R. Hirschhorn. 1986. Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells. J. Clin. Invest. 78:760-770.
10. Firestein, G. S., et al. 1995. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins. J. Immunol. 154: 326-334.
11. Fredholm, B. B. 1997. Purines and neutrophil leukocytes. Gen. Pharmacol. 28:345-350.
12. Fredholm, B. B., A. P. Ijzerman, K. A. Jacobson, K. N. Klotz, and J. Linden. 2001. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53:527-552.
13. Frendéus, B., et al. 2000. Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart. J. Exp. Med. 192:881-890.
14. Godaly, G., et al. 1998. Role of fimbriae-mediated adherence for neutrophil migration across Escherichia coli-infected epithelial cell layers. Mol. Microbiol. 30:725-735.
15. Godaly, G., A. E. Proudfoot, R. E. Offord, C. Svanborg, and W. W. Agace. 1997. Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration. Infect. Immun. 65:3451-3456.
16. Hang, L., B. Frendéus, G. Godaly, and C. Svanborg. 2000. Interleukin-8 receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis. J. Infect. Dis. 182:1738-1748.
17. 2A receptors in inflammation and injury: lessons learned from transgenic animals. J. Leukoc. Biol. 83:447-455.
18. Holloway, A. F., S. Rao, and M. F. Shannon. 2002. Regulation of cytokine gene transcription in the immune system. Mol. Immunol. 38:567-580.
19. Kumar, V., and A. Sharma. 2009. Adenosine: an endogenous modulator of innate immune system with therapeutic potential. Eur. J. Pharmacol. 616:7-15.
20. Linden, J. 2006. Cell biology. Purinergic chemotaxis. Science 314:1689-1690.
21. 2A adenosine receptor on the profile of chemokines produced by neutrophils. FASEB J. 20:187-189.
22. 2A adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Am. J. Physiol. Renal Physiol. 279: F809-F818.
23. Rao, W. H., C. Murdoch, J. R. Johnson, G. S. Evans, and A. Finn. 2001. Uropathogenic Escherichia coli-induced neutrophil adhesion to urinary epithelium is strain-specific and mediated by CD11b/CD18. Urol. Res. 29:102-107.
24. Rossi, M. R., et al. 2001. The immortalized UROtsa cell line as a potential cell culture model of human urothelium. Environ. Health Perspect. 109:801-808.
25. Säve, S., J. Mjösberg, M. Poljakovic, C. Mohlin, and K. Persson. 2009. Adenosine receptor expression in Escherichia coli-infected and cytokinestimulated human urinary tract epithelial cells. BJU Int. 104:1758-1765.
26. 2B receptor activation on signaling pathways and cytokine production in human uroepithelial cells. Pharmacology 86:129-137.
27. Svanborg, C., et al. 2006. Uropathogenic Escherichia coli as a model of host-parasite interaction. Curr. Opin. Microbiol. 9:33-39.
28. -/- mice. Kidney Int. 67:103-110.
29. Tak, P. P., and G. S. Firestein. 2001. NF-kB: a key role in inflammatory diseases. J. Clin. Invest. 107:7-11.
30. Tarkowski, A., and H. Wagner. 1998. Arthritis and sepsis caused by Staphylococcus aureus: can the tissue injury be reduced by modulating the host's immune system? Mol. Med. Today 4:15-18.
31. Thiel, M., C. C. Caldwell, and M. V. Sitkovsky. 2003. The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases. Microbes Infect. 5:515-526.
32. Wollner, A., S. Wollner, and J. B. Smith. 1993. Acting via A2 receptors, adenosine inhibits the upregulation of Mac-1 (Cd11b/CD18) expression on FMLP-stimulated neutrophils. Am. J. Respir. Cell Mol. Biol. 9:179-185.
33. Yegutkin, G. G. 2008. Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim. Biophys. Acta 1783:673-694.
34. Zen, K., and C. A. Parkos. 2003. Leukocyte-epithelial interactions. Curr. Opin. Cell Biol. 15:557-564.