Evaluation of muscle metaboreflex function through graded reduction in forearm blood flow during rhythmic handgrip exercise in humans

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 2, 2011, Pages

  Ichinose, Masashi ^a   Delliaux, Stephane ^b,c   Watanabe, Kazuhito ^b   Fujii, Naoto ^b   Nishiyasu, Takeshi ^b  

^a MEIJI UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c Public Hospitals Marseille   (France)

Author keywords

Integrated circulatory regulation; Neural cardiovascular regulation; Peripheral reflexes

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONDUCTANCE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; EXERCISE; FEMALE; FOREARM BLOOD FLOW; HAND GRIP; HEART RATE; HEMODYNAMICS; HUMAN; MALE; MEAN ARTERIAL PRESSURE; METABOLIC REGULATION; MUSCLE FUNCTION; NORMAL HUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; REFLEX;

ADULT; ANALYSIS OF VARIANCE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CARDIAC OUTPUT; EXERCISE; FEMALE; FOREARM; HAND STRENGTH; HEART RATE; HEMODYNAMICS; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MUSCLE CONTRACTION; MUSCLE STRENGTH DYNAMOMETER; MUSCLE, SKELETAL; PERIODICITY; REFLEX; REGIONAL BLOOD FLOW; TIME FACTORS; YOUNG ADULT;

EID: 79961096105     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00076.2011     Document Type: Article

References (41)

1. Alam M, Smirk FH. Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol 89: 372-383, 1937.
2. Augustyniak RA, Collins HL, Ansorge EJ, Rossi NF, O'Leary DS. Severe exercise alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 280: H1645-H1652, 2001.
3. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14: 377-381, 1982.
4. Casey DP, Joyner MJ. Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans. J Appl Physiol 107: 429-437, 2009.
5. Coutsos M, Sala-Mercado JA, Ichinose M, Li Z, Dawe EJ, O'Leary DS. Muscle metaboreflex-induced coronary vasoconstriction functionally limits increases in ventricular contractility. J Appl Physiol 109: 271-278, 2010.
6. Crisafulli A, Salis E, Pittau G, Lorrai L, Tocco F, Melis F, Pagliaro P, Concu A. Modulation of cardiac contractility by muscle metaboreflex following efforts of different intensities in humans. Am J Physiol Heart Circ Physiol 291: H3035-H3042, 2006.
7. Daley JCIII, Khan MH, Hogeman CS, Sinoway LI. Autonomic and vascular responses to reduced limb perfusion. J Appl Physiol 95: 1493-1498, 2003.
8. Eiken O, Bjurstedt H. Dynamic exercise in man as influenced by experimental restriction of blood flow in the working muscles. Acta Physiol Scand 131: 339-345, 1987.
9. Fisher JP, Seifert T, Hartwich D, Young CN, Secher NH, Fadel PJ. Autonomic control of heart rate by metabolically sensitive skeletal muscle afferents in humans. J Physiol 588: 1117-1127, 2010.
10. Gollnick PD, Riedy M, Quintinskie JJ, Bertocci LA. Differences in metabolic potential of skeletal muscle fibres and their significance for metabolic control. J Exp Biol 115: 191-199, 1985.
11. Hammond RL, Augustyniak RA, Rossi NF, Churchill PC, Lapanowski K, O'Leary DS. Heart failure alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 278: H818-H828, 2000.
12. Ichinose M, Nishiyasu T. Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans. Am J Physiol Heart Circ Physiol 288: H1532-H1538, 2005.
13. Ichinose M, Koga S, Fujii N, Kondo N, Nishiyasu T. Modulation of the spontaneous beat-to-beat fluctuations in peripheral vascular resistance during activation of muscle metaboreflex. Am J Physiol Heart Circ Physiol 293: H416-H424, 2007.
14. Ichinose M, Saito M, Kondo N, Nishiyasu T. Time-dependent modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans. Am J Physiol Heart Circ Physiol 290: H1419-H1426, 2006.
15. Ichinose M, Sala-Mercado JA, Coutsos M, Li Z, Ichinose TK, Dawe E, O'Leary DS. Modulation of cardiac output alters the mechanisms of the muscle metaboreflex pressor response. Am J Physiol Heart Circ Physiol 298: H245-H250, 2010.
16. Ichinose M, Sala-Mercado JA, O'Leary DS, Hammond RL, Coutsos M, Ichinose T, Pallante M, Iellamo F. Spontaneous baroreflex control of cardiac output during dynamic exercise, muscle metaboreflex activation, and heart failure. Am J Physiol Heart Circ Physiol 294: H1310-H1316, 2008.
17. Joyner MJ. Does the pressor response to ischemic exercise improve blood flow to contracting muscles in humans? J Appl Physiol 71: 1496-1501, 1991.
18. Joyner MJ. Muscle chemoreflexes and exercise in humans. Clin Auton Res 2: 201-208, 1992.
19. Kitano A, Shoemaker JK, Ichinose M, Wada H, Nishiyasu T. Comparison of cardiovascular responses between lower body negative pressure and head-up tilt. J Appl Physiol 98: 2081-2086, 2005.
20. Kubicek WG, Kottke FJ, Ramos MU, Patterson RP, Witsoe DA, LaBree JW, Remole W, Layman TE, Schoening H, Garamela JT. The Minnesota impedance cardiography-theory and applications. Biomed Environ Sci 9: 410-416, 1974.
21. Kumada M, Azuma T, Matsuda K. The cardiac output-heart rate relationship under different conditions. Jpn J Physiol 17: 538-555, 1967.
22. McClain J, Hardy C, Enders B, Smith M, Sinoway L. Limb congestion and sympathoexcitation during exercise. Implications for congestive heart failure. J Clin Invest 92: 2353-2359, 1993.
23. Mitchell JH. Neural control of the circulation during exercise. Med Sci Sports Exerc 22: 141-154, 1990.
24. Nishiyasu T, Hayashida S, Kitano A, Nagashima K, Ichinose M. Effects of posture on peripheral vascular responses to lower body positive pressure. Am J Physiol Heart Circ Physiol 293: H670-H676, 2007.
25. Nishiyasu T, Nagashima K, Nadel ER, Mack GW. Effects of posture on cardiovascular responses to lower body positive pressure at rest and during dynamic exercise. J Appl Physiol 85: 160-167, 1998.
26. Nishiyasu T, Nagashima K, Nadel ER, Mack GW. Human cardiovascular and humoral responses to moderate muscle activation during dynamic exercise. J Appl Physiol 88: 300-307, 2000.
27. Nishiyasu T, Tan N, Morimoto K, Nishiyasu M, Yamaguchi Y, Murakami N. Enhancement of parasympathetic cardiac activity during activation of muscle metaboreflex in humans. J Appl Physiol 77: 2778-2783, 1994.
28. O'Leary DS, Augustyniak RA. Muscle metaboreflex increases ventricular performance in conscious dogs. Am J Physiol Heart Circ Physiol 275: H220-H224, 1998.
29. O'Leary DS. Autonomic mechanisms of muscle metaboreflex control of heart rate. J Appl Physiol 74: 1748-1754, 1993.
30. Rowell LB, O'Leary DS. Reflex control of the circulation during exercise: chemoreflex and mechanoreflexes. J Appl Physiol 69: 407-418, 1990.
31. Rowell LB, O'Leary DS, Kellogg Jr DL. Integration of Cardiovascular Control Systems in Dynamic Exercise. New York, NY: Oxford, 1996, p. 770-838.
32. Rowell LB, Savage MV, Chambers J, Blackmon JR. Cardiovascular responses to graded reductions in leg perfusion in exercising humans. Am J Physiol Heart Circ Physiol 261: H1545-H1553, 1991.
33. Sala-Mercado JA, Hammond RL, Kim JK, Rossi NF, Stephenson LW, O'Leary DS. Muscle metaboreflex control of ventricular contractility during dynamic exercise. Am J Physiol Heart Circ Physiol 290: H751-H757, 2006.
34. Sala-Mercado JA, Ichinose M, Coutsos M, Li Z, Fano D, Ichinose T, Dawe EJ, O'Leary DS. Progressive muscle metaboreflex activation gradually decreases spontaneous heart rate baroreflex sensitivity during dynamic exercise. Am J Physiol Heart Circ Physiol 298: H594-H600, 2010.
35. Sheriff DD, Augustyniak RA, O'Leary DS. Muscle chemoreflex-induced increases in right atrial pressure. Am J Physiol Heart Circ Physiol 275: H767-H775, 1998.
36. Sheriff DD, O'Leary DS, Scher AM, Rowell LB. Baroreflex attenuates pressor response to graded muscle ischemia in exercising dogs. Am J Physiol Heart Circ Physiol 258: H305-H310, 1990.
37. Victor RG, Seals DR. Reflex stimulation of sympathetic outflow during rhythmic exercise in humans. Am J Physiol Heart Circ Physiol 257: H2017-H2024, 1989.
38. Victor RG, Pryor SL, Secher NH, Mitchell JH. Effects of partial neuromuscular blockade on sympathetic nerve responses to static exercise in humans. Circ Res 65: 468-476, 1989.
39. Watanabe K, Ichinose M, Fujii N, Matsumoto M, Nishiyasu T. Individual differences in the heart rate response to activation of the muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol 299: H1708- H1714, 2010.
40. White S, Higgins CB, Vatner SF, Franklin D, Braunwald E, Patrick T. Effects of altering ventricular rate on blood flow distribution in conscious dogs. Am J Physiol 221: 1402-1407, 1971.
41. Wyss CR, Ardell JL, Scher AM, Rowell LB. Cardiovascular responses to graded reductions in hindlimb perfusion in exercising dogs. Am J Physiol Heart Circ Physiol 245: H481-H486, 1983.