CNS irradiation in pediatric acute myleoid leukemia: Equal results by 12 or 18 Gy in studies AML-BFM98 and 2004

Pediatric Blood and Cancer

Volumn 57, Issue 6, 2011, Pages 986-992

  Creutzig, Ursula ^a   Zimmermann, Martin ^b   Bourquin, Jean Pierre ^c   Dworzak, Michael N ^d   Fleischhack, Gudrun ^e   von Neuhoff, Christine ^b   Sander, Annette ^b   Schrauder, André ^f   von Stackelberg, Arend ^g   Ritter, Joerg ^a   Starý, Jan ^h   Reinhardt, Dirk ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d ST ANNA CHILDREN S HOSPITAL   (Austria)

^e Department of Pediatric Hematology/ Oncology   (Germany)

^f UNIVERSITY OF KIEL   (Germany)

^g CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^h CHARLES UNIVERSITY   (Czech Republic)

Author keywords

AML; Clinical trials; Leukemia; Molecular diagnosis and therapy; Outcomes research; Radiation therapy

Indexed keywords

ANTHRACYCLINE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; IDARUBICIN; MITOXANTRONE;

ACUTE GRANULOCYTIC LEUKEMIA; ALOPECIA; ARTICLE; BONE MARROW BIOPSY; CANCER DIAGNOSIS; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER RISK; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM; CHILD; CHILDHOOD CANCER; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCHOOL CHILD;

ADOLESCENT; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD; FEMALE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; RECURRENCE;

EID: 79961073023     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22955     Document Type: Article

References (23)

1. Aur RJ, Simone J, Hustu HO, et al. Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. Blood 1971; 37: 272-281.
2. Kaspers GJ, Creutzig U. Pediatric acute myeloid leukemia: International progress and future directions. Leukemia 2005; 19: 2025-2029.
3. Creutzig U, Ritter J, Zimmermann M, et al. Does cranial irradiation reduce the risk for bone marrow relapse in acute myelogenous leukemia (AML): Unexpected results of the childhood AML Study BFM-87. J Clin Oncol 1993; 11: 279-286.
4. Bennett JM, Catovsky D, Daniel MT, et al. Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med 1985; 103: 626-629.
5. Bennett JM, Catovsky D, Daniel MT, et al. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group. Ann Intern Med 1985; 103: 460-462.
6. Bennett JM, Catovsky D, Daniel MT, et al. Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-M0). Br J Haematol 1991; 78: 325-329.
7. Creutzig U, Zimmermann M, Lehrnbecher T, et al. Less toxicity by optimizing chemotherapy, but not by addition of granulocyte colony-stimulating factor in children and adolescents with acute myeloid leukemia: Results of AML-BFM 98. J Clin Oncol 2006; 24: 4499-4506.
8. Cheson BD, Cassileth PA, Head DR, et al. Report of the National Cancer Institute-sponsored workshop on definitions and response in acute myeloid leukemia. J Clin Oncol 1990; 8: 813-819.
9. Kalbfleisch J, Prentice R, The Statistical. Analysis of failure time data. New York, NY: Wiley; 2002.
10. Pinkel D, Simone J, Hustu HO, et al. Nine years' experience with "total therapy" of childhood acute lymphocytic leukemia. Pediatrics 1972; 50: 246-251.
11. Pui CH, Howard SC. Current management and challenges of malignant disease in the CNS in paediatric leukaemia. Lancet Oncol 2008; 9: 257-268.
12. Dahl GV, Simone JV, Hustu HO, et al. Preventive central nervous system irradiation in children with acute nonlymphocytic leukemia. Cancer 1978; 42: 2187-2192.
13. Dongen-Melman JE, De Groot A, van Dongen JJ, et al. Cranial irradiation is the major cause of learning problems in children treated for leukemia and lymphoma: A comparative study. Leukemia 1997; 11: 1197-1200.
14. Creutzig U, Zimmermann M, Ritter J, et al. Treatment strategies and long-term results in paediatric patients treated in four consecutive AML-BFM trials. Leukemia 2005; 19: 2030-2042.
15. Gibson BE, Wheatley K, Hann IM, et al. Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trials. Leukemia 2005; 19: 2130-2138.
16. Lie SO, Abrahamsson J, Clausen N, et al. Treatment stratification based on initial in vivo response in acute myeloid leukaemia in children without Down's syndrome: Results of NOPHO-AML trials. Br J Haematol 2003; 122: 217-225.
17. Tomizawa D, Tabuchi K, Kinoshita A, et al. Repetitive cycles of high-dose cytarabine are effective for childhood acute myeloid leukemia: Long-term outcome of the children with AML treated on two consecutive trials of Tokyo Children's Cancer Study Group. Pediatr Blood Cancer 2007; 49: 127-132.
18. Abbott BL, Rubnitz JE, Tong X, et al. Clinical significance of central nervous system involvement at diagnosis of pediatric acute myeloid leukemia: A single institution's experience. Leukemia 2003; 17: 2090-2096.
19. Phuphanich S, Maria B, Braeckman R, et al. A pharmacokinetic study of intra-CSF administered encapsulated cytarabine (DepoCyt) for the treatment of neoplastic meningitis in patients with leukemia, lymphoma, or solid tumors as part of a phase III study. J Neurooncol 2007; 81: 201-208.
20. Duffner PK. Long-term effects of radiation therapy on cognitive and endocrine function in children with leukemia and brain tumors. Neurologist 2004; 10: 293-310.
21. Loning L, Zimmermann M, Reiter A, et al. Secondary neoplasms subsequent to Berlin-Frankfurt-Munster therapy of acute lymphoblastic leukemia in childhood: Significantly lower risk without cranial radiotherapy. Blood 2000; 95: 2770-2775.
22. Pui CH, Pei D, Sandlund JT, et al. Long-term results of St Jude total therapy studies 11, 12 13A, 13B, and 14 for childhood acute lymphoblastic leukemia. Leukemia 2010; 24: 371-382.
23. Reinhardt D, Thiele C, Creutzig U. Neuropsychological sequelae in children with AML treated with or without prophylactic CNS-irradiation. Klin Pädiatr 2002; 214: 22-29.