Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain

Brain, Behavior, and Immunity

Volumn 25, Issue 7, 2011, Pages 1342-1348

  Van Velthoven, Cindy T J ^a   Kavelaars, Annemieke ^a,b   Van Bel, Frank ^a   Heijnen, Cobi J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Bone marrow stromal cell; Brain ischemia; Cell transplantation; Cytokines; Growth factors; Regenerative medicine

Indexed keywords

CYTOKINE; GREEN FLUORESCENT PROTEIN; GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENGRAFTMENT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPOTHESIS; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NERVE REGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE REGENERATION;

ANIMALS; ANIMALS, NEWBORN; BRAIN; FEMALE; GENE EXPRESSION PROFILING; HYPOXIA-ISCHEMIA, BRAIN; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; NEURONS;

EID: 79961066356     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2011.03.021     Document Type: Article

References (25)

1. Allan S.M., Rothwell N.J. Cytokines and acute neurodegeneration. Nat. Rev. Neurosci. 2001, 2:734-744.
2. Bartley J., Soltau T., Wimborne H., Kim S., Martin-Studdard A., Hess D., Hill W., Waller J., Carroll J. BrdU-positive cells in the neonatal mouse hippocampus following hypoxic-ischemic brain injury. BMC Neurosci. 2005, 6:15.
3. Bauer S., Patterson P.H. Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J. Neurosci. 2006, 26:12089-12099.
4. Carmichael S.T. Themes and strategies for studying the biology of stroke recovery in the poststroke epoch. Stroke 2008, 39:1380-1388.
5. Daadi M.M., Davis A.S., Arac A., Li Z., Maag A.L., Bhatnagar R., Jiang K., Sun G., Wu J.C., Steinberg G.K. Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury. Stroke 2010, 41:516-523.
6. Degos V., Loron G., Mantz J., Gressens P. Neuroprotective strategies for the neonatal brain. Anesth. Analg. 2008, 106:1670-1680.
7. Ferriero D.M. Neonatal brain injury. N. Engl. J. Med. 2004, 351:1985-1995.
8. Hedtjarn M., Mallard C., Eklind S., Gustafson-Brywe K., Hagberg H. Global gene expression in the immature brain after hypoxia-ischemia. J. Cereb. Blood Flow Metab. 2004, 24:1317-1332.
9. Heyden A., Angenstein F., Sallaz M., Seidenbecher C., Montag D. Abnormal axonal guidance and brain anatomy in mouse mutants for the cell recognition molecules close homolog of L1 and NgCAM-related cell adhesion molecule. Neuroscience 2008, 155:221-233.
10. Lee J.A., Kim B.I., Jo C.H., Choi C.W., Kim E.K., Kim H.S., Yoon K.S., Choi J.H. Mesenchymal stem-cell transplantation for hypoxic-ischemic brain injury in neonatal rat model. Pediatr. Res. 2010, 67:42-46.
11. Leker R.R., Lasri V., Chernoguz D. Growth factors improve neurogenesis and outcome after focal cerebral ischemia. J. Neural Transm. 2009, 116:1397-1402.
12. Mezey E., Chandross K.J., Harta G., Maki R.A., McKercher S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000, 290:1779-1782.
13. Miller F.D., Gauthier A.S. Timing is everything: making neurons versus glia in the developing cortex. Neuron 2007, 54:357-369.
14. Nakatomi H., Kuriu T., Okabe S., Yamamoto S., Hatano O., Kawahara N., Tamura A., Kirino T., Nakafuku M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002, 110:429-441.
15. Pimentel-Coelho P.M., Mendez-Otero R. Cell therapy for neonatal hypoxic-ischemic encephalopathy. Stem Cells Dev. 2010, 19:299-310.
16. Qiu R., Wang X., Davy A., Wu C., Murai K., Zhang H., Flanagan J.G., Soriano P., Lu Q. Regulation of neural progenitor cell state by ephrin-B. J. Cell Biol. 2008, 181:973-983.
17. Qu R., Li Y., Gao Q., Shen L., Zhang J., Liu Z., Chen X., Chopp M. Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts. Neuropathology 2007, 27:355-363.
18. Skaper S.D. Neuronal growth-promoting and inhibitory cues in neuroprotection and neuroregeneration. Ann. N. Y. Acad. Sci. 2005, 1053:376-385.
19. Titomanlio L., Bouslama M., Verche V.L., Dalous J., Kaindl A.M., Tsenkina Y., Lacaud A., Peineau S., Ghouzzi V.E., Lelievre V., Gressens P. Implanted neurosphere-derived precursors promote recovery after neonatal excitotoxic brain injury. Stem Cells Dev. 2011.
20. van Velthoven C.T., Kavelaars A., van Bel F., Heijnen C.J. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration. Brain Behav. Immun. 2010, 24:387-393.
21. van Velthoven C.T., Kavelaars A., van Bel F., Heijnen C.J. Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function. J. Neurosci. 2010, 30:9603-9611.
22. van Velthoven C.T., Kavelaars A., van Bel F., Heijnen C.J. Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes. Brain Res. Rev. 2009, 61:1-13.
23. Yang Z., Covey M.V., Bitel C.L., Ni L., Jonakait G.M., Levison S.W. Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Ann. Neurol. 2007, 61:199-208.
24. Yasuhara T., Hara K., Maki M., Mays R.W., Deans R.J., Hess D.C., Carroll J.E., Borlongan C.V. Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats. J. Cereb. Blood Flow Metab. 2008, 28:1804-1810.
25. Ziemba K.S., Chaudhry N., Rabchevsky A.G., Jin Y., Smith G.M. Targeting axon growth from neuronal transplants along preformed guidance pathways in the adult CNS. J. Neurosci. 2008, 28:340-348.