Thrombophilic factors in Stage v chronic kidney disease patients are largely corrected by renal transplantation

Nephrology Dialysis Transplantation

Volumn 26, Issue 8, 2011, Pages 2700-2705

  Ghisdal, Lidia ^a   Broeders, Nilufer ^a   Wissing, Karl Martin ^b   Mena, Joseph Mbaba ^a   Lemy, Anne ^a   Wijns, Walter ^a   Pradier, Olivier ^a   Donckier, Vincent ^a   Racapé, Judith ^c   Vereerstraeten, Pierre ^a   Abramowicz, Daniel ^a  

^a ERASME HOSPITAL   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^c FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

coagulation; haemodialysis; renal transplantation; thrombophilia

Indexed keywords

ACENOCOUMAROL; ACETYLSALICYLIC ACID; ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; BLOOD CLOTTING FACTOR 8C; CYCLOSPORIN; HEPARIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR BLOCKING AGENT; LOW MOLECULAR WEIGHT HEPARIN; LUPUS ANTICOAGULANT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHOSPHOLIPID ANTIBODY; PROTEIN C; PROTEIN S; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ACTIVATED PROTEIN C RESISTANCE; ADULT; ANTITHROMBIN DEFICIENCY; ARTICLE; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DISEASE SEVERITY; FEMALE; HEART ATRIUM FIBRILLATION; HEMODIALYSIS; HIGH RISK POPULATION; HUMAN; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PERITONEAL DIALYSIS; POSTOPERATIVE PERIOD; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RENAL REPLACEMENT THERAPY; THROMBOEMBOLISM; THROMBOPHILIA; VEIN THROMBOSIS;

BLOOD COAGULATION FACTORS; CARDIOVASCULAR DISEASES; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INCIDENCE; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RENAL DIALYSIS; THROMBOPHILIA;

EID: 79961059922     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq791     Document Type: Article

References (33)

1. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001;19:1222-1231 (Pubitemid 32319498)
2. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999;353:1167-1173 (Pubitemid 29155221)
3. Ghisdal L, Broeders N, Wissing KM et al. Thrombophilic factors do not predict outcomes in renal transplant recipients under prophylactic acetylsalicylic acid. Am J Transplant 2010;10:99-105
4. Heidenreich S, Dercken C, August C et al. High rate of acute rejections in renal allograft recipients with thrombophilic risk factors. J Am Soc Nephrol 1998;9:1309-1313 (Pubitemid 28283896)
5. Nampoory MR, Das KC, Johny KV et al. Hypercoagulability, a serious problem in patients with ESRD on maintenance hemodialysis, and its correction after kidney transplantation. Am J Kidney Dis 2003;42:797-805 (Pubitemid 37187381)
6. Ducloux D, Bourrinet E, Motte G et al. Antiphospholipid antibodies as a risk factor for atherosclerotic events in renal transplant recipients. Kidney Int 2003;64:1065-1070 (Pubitemid 37013844)
7. Garcia-Martin F, De Arriba G, Carrascosa T et al. Anticardiolipin antibodies and lupus anticoagulant in end-stage renal disease. Nephrol Dial Transplant 1991;6:543-547
8. Fernandez-Abreu MC, Diez-Ewald M, Briceno S et al. Frequency and clinical implications of lupus anticoagulant in patients with terminal chronic renal failure in hemodialysis. Invest Clin 2007;48:69-79 (Pubitemid 46718387)
9. Skouri H, Gandouz R, Abroug S et al. A prospective study of the prevalence of heparin-induced antibodies and other associated thromboembolic risk factors in pediatric patients undergoing hemodialysis. Am J Hematol 2006;81:328-334
10. Quereda C, Pardo A, Lamas S et al. Lupus-like in vitro anticoagulant activity in end-stage renal disease. Nephron 1988;49:39-44 (Pubitemid 18091090)
11. Knoll GA, Wells PS, Young D et al. Thrombophilia and the risk for hemodialysis vascular access thrombosis. J Am Soc Nephrol 2005;16:1108-1114 (Pubitemid 41710322)
12. Fischereder M, Gohring P, Schneeberger H et al. Early loss of renal transplants in patients with thrombophilia. Transplantation 1998;65:936-939 (Pubitemid 28201446)
13. Ducloux D, Pellet E, Fournier V et al. Prevalence and clinical significance of antiphospholipid antibodies in renal transplant recipients. Transplantation 1999;67:90-93 (Pubitemid 29061143)
14. Fischereder M, Schneeberger H, Lohse P et al. Increased rate of renal transplant failure in patients with the G20210A mutation of the prothrombin gene. Am J Kidney Dis 2001;38:1061-1064 (Pubitemid 33022184)
15. Wuthrich RP, Cicvara-Muzar S, Booy C et al. Heterozygosity for the factor V Leiden (G1691A) mutation predisposes renal transplant recipients to thrombotic complications and graft loss. Transplantation 2001;72:549-550 (Pubitemid 32769651)
16. Ekberg H, Svensson PJ, Simanaitis M et al. Factor V R506Q mutation (activated protein C resistance) is an additional risk factor for early renal graft loss associated with acute vascular rejection. Transplantation 2000;69:1577-1581
17. Meyer M, Laux G, Scherer S et al. No association of factor V Leiden, prothrombin G20210A, and MTHFR C677T gene polymorphisms with kidney allograft survival: a multicenter study. Transplantation 2007;83:1055-1058 (Pubitemid 46659117)
18. Alakulppi NS, Kyllonen LE, Partanen J et al. Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation. Nephrol Dial Transplant 2008;23:364-368 (Pubitemid 351767361)
19. Winkelmayer WC, Kramar R, Sunder-Plassmann G et al. Effects of single-nucleotide polymorphisms in MTHFR and MTRR on mortality and allograft loss in kidney transplant recipients. Kidney Int 2005;68:2857-2862 (Pubitemid 43251033)
20. Wu O, Robertson L, Twaddle S et al. Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol Assess 2006;10:1-110
21. Dykes AC, Walker ID, McMahon AD. A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state. Br J Haematol 2001;113:636-641 (Pubitemid 32524382)
22. Lim W, Crowther MA, Eikelboom JW. Management of antiphospholipid antibody syndrome: a systematic review. JAMA 2006;295:1050-1057
23. Frank RD, Weber J, Dresbach H et al. Role of contact system activation in hemodialyzer-induced thrombogenicity. Kidney Int 2001;60:1972-1981 (Pubitemid 33000004)
24. Vaziri ND, Gonzales EC, Wang J et al. Blood coagulation, fibrinolytic, and inhibitory proteins in end-stage renal disease: effect of hemodialysis. Am J Kidney Dis 1994;23:828-835 (Pubitemid 24173566)
25. Shi W, Krilis SA, Chong BH et al. Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population. Aust N Z J Med 1990;20:231-236 (Pubitemid 20283041)
26. Al-Massarani G, Vacher-Coponat H, Paul P et al. Kidney transplantation decreases the level and procoagulant activity of circulating microparticles. Am J Transplant 2009;9:550-557
27. Fried L, Solomon C, Shlipak M et al. Inflammatory and prothrombotic markers and the progression of renal disease in elderly individuals. J Am Soc Nephrol 2004;15:3184-3191 (Pubitemid 39578851)
28. Shlipak MG, Fried LF, Crump C et al. Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency. Circulation 2003;107:87-92 (Pubitemid 36070938)
29. Keller C, Katz R, Cushman M et al. Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA). BMC Nephrol 2008;9:9
30. Ardoin SP, Shanahan JC, Pisetsky DS. The role of microparticles in inflammation and thrombosis. Scand J Immunol 2007;66:159-165 (Pubitemid 47063209)
31. Huser B, Lammle B, Landmann J et al. von Willebrand factor and factor VIII in renal transplant recipients under immunosuppression with cyclosporine and steroids. Sequential measurements over 4 months in 17 patients. Clin Nephrol 1990;34:214-222
32. Kujovich JL. Thrombophilia and thrombotic problems in renal transplant patients. Transplantation 2004;77:959-964 (Pubitemid 38508906)
33. Irish AB, Green FR, Gray DW et al. The factor V Leiden (R506Q) mutation and risk of thrombosis in renal transplant recipients. Transplantation 1997;64:604-607 (Pubitemid 27377192)