Crystal structures of λ exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 29, 2011, Pages 11872-11877

  Zhang, Jinjin ^a,b   McCabe, Kimberly A ^a   Bella, Charles E ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

DNA repair; Enzyme mechanism; Homologous recombination; Recombineering; Single strand annealing

Indexed keywords

DOUBLE STRANDED DNA; EXONUCLEASE; LAMBDA EXONUCLEASE; MAGNESIUM ION; PHOSPHATE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE INSERTION; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION;

BASE SEQUENCE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, ION EXCHANGE; CRYSTALLIZATION; DNA; EXONUCLEASES; FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OLIGONUCLEOTIDES; PROTEIN CONFORMATION; SEQUENCE ANALYSIS, DNA; STATIC ELECTRICITY; X-RAY DIFFRACTION;

EID: 79961050090     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1103467108     Document Type: Article

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