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Volumn 19, Issue 8, 2011, Pages 1426-1432

Synergistic inhibition of endochondral bone formation by silencing Hif1α and Runx2 in trauma-induced heterotopic ossification

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; LENTIVIRUS VECTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2;

EID: 79961021928     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.101     Document Type: Article
Times cited : (58)

References (33)
  • 3
    • 77955983359 scopus 로고    scopus 로고
    • Hypoxia, HIFs and bone development
    • Araldi, E and Schipani, E (2010). Hypoxia, HIFs and bone development. Bone 47: 190-196.
    • (2010) Bone , vol.47 , pp. 190-196
    • Araldi, E.1    Schipani, E.2
  • 4
    • 36549088609 scopus 로고    scopus 로고
    • HIF1α regulation of Sox9 in necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis
    • DOI 10.1242/dev.008441
    • Amarilio, R, Viukov, SV, Sharir, A, Eshkar-Oren, I, Johnson, RS and Zelzer, E (2007). HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development 134: 3917-3928. (Pubitemid 350187350)
    • (2007) Development , vol.134 , Issue.21 , pp. 3917-3928
    • Amarilio, R.1    Viukov, S.V.2    Sharir, A.3    Eshkar-Oren, I.4    Johnson, R.S.5    Zelzer, E.6
  • 5
    • 77953499330 scopus 로고    scopus 로고
    • Vessel formation is induced prior to the appearance of cartilage in BMP-2- mediated heterotopic ossification
    • Dilling, CF, Wada, AM, Lazard, ZW, Salisbury, EA, Gannon, FH, Vadakkan, TJ et al. (2010). Vessel formation is induced prior to the appearance of cartilage in BMP-2- mediated heterotopic ossification. J Bone Miner Res 25: 1147-1156.
    • (2010) J Bone Miner Res , vol.25 , pp. 1147-1156
    • Dilling, C.F.1    Wada, A.M.2    Lazard, Z.W.3    Salisbury, E.A.4    Gannon, F.H.5    Vadakkan, T.J.6
  • 6
    • 77951242575 scopus 로고    scopus 로고
    • Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts
    • Tseng, WP, Yang, SN, Lai, CH and Tang, CH (2010). Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts. J Cell Physiol 223: 810-818.
    • (2010) J Cell Physiol , vol.223 , pp. 810-818
    • Tseng, W.P.1    Yang, S.N.2    Lai, C.H.3    Tang, C.H.4
  • 7
    • 0035341209 scopus 로고    scopus 로고
    • TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
    • DOI 10.1093/emboj/20.9.2254
    • Alliston, T, Choy, L, Ducy, P, Karsenty, G and Derynck, R (2001). TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 20: 2254-2272. (Pubitemid 32410595)
    • (2001) EMBO Journal , vol.20 , Issue.9 , pp. 2254-2272
    • Alliston, T.1    Choy, L.2    Ducy, P.3    Karsenty, G.4    Derynck, R.5
  • 10
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy, P, Zhang, R, Geoffroy, V, Ridall, AL and Karsenty, G (1997). Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89: 747-754. (Pubitemid 27516177)
    • (1997) Cell , vol.89 , Issue.5 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 11
    • 33748475848 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of siRNA against Runx2/Cbfa1 inhibits the formation of heterotopic ossification in animal model
    • DOI 10.1016/j.bbrc.2006.08.089, PII S0006291X0601864X
    • Lin, L, Chen, L, Wang, H, Wei, X, Fu, X, Zhang, J et al. (2006). Adenovirus-mediated transfer of siRNA against Runx2/Cbfa1 inhibits the formation of heterotopic ossification in animal model. Biochem Biophys Res Commun 349: 564-572. (Pubitemid 44349141)
    • (2006) Biochemical and Biophysical Research Communications , vol.349 , Issue.2 , pp. 564-572
    • Lin, L.1    Chen, L.2    Wang, H.3    Wei, X.4    Fu, X.5    Zhang, J.6    Ma, K.7    Zhou, C.8    Yu, C.9
  • 12
    • 77949425482 scopus 로고    scopus 로고
    • Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats
    • Xue, T, Mao, Z, Lin, L, Hou, Y, Wei, X, Fu, X et al. (2010). Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats. Gene Ther 17: 370-379.
    • (2010) Gene Ther , vol.17 , pp. 370-379
    • Xue, T.1    Mao, Z.2    Lin, L.3    Hou, Y.4    Wei, X.5    Fu, X.6
  • 13
    • 74249110557 scopus 로고    scopus 로고
    • Heterotopic ossification induced by achilles tenotomy via endochondral bone formation: Expression of bone and cartilage related genes
    • Lin, L, Shen, Q, Xue, T and Yu, C (2010). Heterotopic ossification induced by Achilles tenotomy via endochondral bone formation: expression of bone and cartilage related genes. Bone 46: 425-431.
    • (2010) Bone , vol.46 , pp. 425-431
    • Lin, L.1    Shen, Q.2    Xue, T.3    Yu, C.4
  • 14
    • 0024346942 scopus 로고
    • A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions
    • Muller, WA, Ratti, CM, McDonnell, SL and Cohn, ZA (1989). A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med 170: 399-414. (Pubitemid 19204271)
    • (1989) Journal of Experimental Medicine , vol.170 , Issue.2 , pp. 399-414
    • Muller, W.A.1    Ratti, C.M.2    McDonnell, S.L.3    Cohn, Z.A.4
  • 16
    • 27444446737 scopus 로고    scopus 로고
    • VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis
    • DOI 10.1359/JBMR.050708
    • Peng, H, Usas, A, Olshanski, A, Ho, AM, Gearhart, B, Cooper, GM et al. (2005). VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis. J Bone Miner Res 20: 2017-2027. (Pubitemid 41532787)
    • (2005) Journal of Bone and Mineral Research , vol.20 , Issue.11 , pp. 2017-2027
    • Peng, H.1    Usas, A.2    Olshanski, A.3    Ho, A.M.4    Gearhart, B.5    Cooper, G.M.6    Huard, J.7
  • 17
    • 0036738338 scopus 로고    scopus 로고
    • Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4
    • Peng, H, Wright, V, Usas, A, Gearhart, B, Shen, HC, Cummins, J et al. (2002). Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 110: 751-759.
    • (2002) J Clin Invest , vol.110 , pp. 751-759
    • Peng, H.1    Wright, V.2    Usas, A.3    Gearhart, B.4    Shen, H.C.5    Cummins, J.6
  • 18
    • 73849108257 scopus 로고    scopus 로고
    • Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development
    • Shomento, SH, Wan, C, Cao, X, Faugere, MC, Bouxsein, ML, Clemens, TL et al. (2010). Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development. J Cell Biochem 109: 196-204.
    • (2010) J Cell Biochem , vol.109 , pp. 196-204
    • Shomento, S.H.1    Wan, C.2    Cao, X.3    Faugere, M.C.4    Bouxsein, M.L.5    Clemens, T.L.6
  • 19
    • 48749086529 scopus 로고    scopus 로고
    • Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: A role for AKT and hypoxiainducible factor (HIF)-1alpha
    • Kanichai, M, Ferguson, D, Prendergast, PJ and Campbell, VA (2008). Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxiainducible factor (HIF)-1alpha. J Cell Physiol 216: 708-715.
    • (2008) J Cell Physiol , vol.216 , pp. 708-715
    • Kanichai, M.1    Ferguson, D.2    Prendergast, P.J.3    Campbell, V.A.4
  • 22
    • 0031964376 scopus 로고    scopus 로고
    • Antiangiogenic agent (TNP-470) inhibition of ectopic bone formation induced by bone morphogenetic protein-2
    • DOI 10.1016/S8756-3282(97)00248-2, PII S8756328297002482
    • Mori, S, Yoshikawa, H, Hashimoto, J, Ueda, T, Funai, H, Kato, M et al. (1998). Antiangiogenic agent (TNP-470) inhibition of ectopic bone formation induced by bone morphogenetic protein-2. Bone 22: 99-105. (Pubitemid 28058499)
    • (1998) Bone , vol.22 , Issue.2 , pp. 99-105
    • Mori, S.1    Yoshikawa, H.2    Hashimoto, J.3    Ueda, T.4    Funai, H.5    Kato, M.6    Takaoka, K.7
  • 23
    • 57349171954 scopus 로고    scopus 로고
    • BMP type i receptor inhibition reduces heterotopic [corrected] ossification
    • Yu, PB, Deng, DY, Lai, CS, Hong, CC, Cuny, GD, Bouxsein, ML et al. (2008). BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med 14: 1363-1369.
    • (2008) Nat Med , vol.14 , pp. 1363-1369
    • Yu, P.B.1    Deng, D.Y.2    Lai, C.S.3    Hong, C.C.4    Cuny, G.D.5    Bouxsein, M.L.6
  • 24
    • 33846498515 scopus 로고    scopus 로고
    • Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice
    • DOI 10.1016/j.bbrc.2006.12.226, PII S0006291X0700006X
    • Otsuru, S, Tamai, K, Yamazaki, T, Yoshikawa, H and Kaneda, Y (2007). Bone marrowderived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Biochem Biophys Res Commun 354: 453-458. (Pubitemid 46161345)
    • (2007) Biochemical and Biophysical Research Communications , vol.354 , Issue.2 , pp. 453-458
    • Otsuru, S.1    Tamai, K.2    Yamazaki, T.3    Yoshikawa, H.4    Kaneda, Y.5
  • 25
    • 33845277598 scopus 로고    scopus 로고
    • Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells
    • DOI 10.1182/blood-2006-05-025098
    • Rüster, B, Göttig, S, Ludwig, RJ, Bistrian, R, Müller, S, Seifried, E et al. (2006). Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells. Blood 108: 3938-3944. (Pubitemid 44864580)
    • (2006) Blood , vol.108 , Issue.12 , pp. 3938-3944
    • Ruster, B.1    Gottig, S.2    Ludwig, R.J.3    Bistrian, R.4    Muller, S.5    Seifried, E.6    Gille, J.7    Henschler, R.8
  • 26
    • 0028097108 scopus 로고
    • Bone and cartilage differentiation
    • DOI 10.1016/0959-437X(94)90141-O
    • Reddi, AH (1994). Bone and cartilage differentiation. Curr Opin Genet Dev 4: 737-744. (Pubitemid 24322911)
    • (1994) Current Opinion in Genetics and Development , vol.4 , Issue.5 , pp. 737-744
    • Reddi, A.H.1
  • 29
    • 0035453298 scopus 로고    scopus 로고
    • The molecular genetics of lentiviral vectors-current and future perspectives
    • Chang, LJ and Gay, EE (2001). The molecular genetics of lentiviral vectors-current and future perspectives. Curr Gene Ther 1: 237-251.
    • (2001) Curr Gene Ther , vol.1 , pp. 237-251
    • Chang, L.J.1    Gay, E.E.2
  • 33
    • 69949178319 scopus 로고    scopus 로고
    • Effects of transforming growth factor-beta1 and vascular endothelial growth factor 165 gene transfer on Achilles tendon healing
    • Hou, Y, Mao, Z, Wei, X, Lin, L, Chen, L, Wang, H et al. (2009). Effects of transforming growth factor-beta1 and vascular endothelial growth factor 165 gene transfer on Achilles tendon healing. Matrix Biol 28: 324-335.
    • (2009) Matrix Biol , vol.28 , pp. 324-335
    • Hou, Y.1    Mao, Z.2    Wei, X.3    Lin, L.4    Chen, L.5    Wang, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.