Ciprofibrate quantification in human plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry for pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 24, 2011, Pages 2361-2368

  Mendes, Fabiana D ^a   Chen, Lu Shi ^c   Borges, André ^c   Babadópulos, Tainah ^c   Ilha, Jaime O ^c   Alkharfy, Khalid M ^d   Mendes, Gustavo D ^a,b,c   De Nucci, Gilberto ^d,e  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSIDADE CAMILO CASTELO BRANCO   (Brazil)

^c Galeno Research Unit   (Brazil)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Ciprofibrate; Healthy volunteer; HPLC MS MS; Pharmacokinetic; Plasma

Indexed keywords

ACCURACY AND PRECISION; ANALYTES; ANALYTICAL COLUMNS; BEZAFIBRATE; CIPROFIBRATE; COLLISION ENERGIES; CONFIDENCE INTERVAL; DECLUSTERING; DIETHYL ETHERS; ELECTROSPRAY TANDEM MASS SPECTROMETRY; GEOMETRIC MEAN; HEALTHY VOLUNTEER; HPLC-MS/MS; HUMAN PLASMAS; INTERNAL STANDARDS; LIMIT OF QUANTIFICATIONS; LINEAR CALIBRATION CURVE; LIQUID-LIQUID EXTRACTION; MOBILE PHASE; OPTIMIZED PARAMETER; PHARMACOKINETIC PARAMETERS; PHARMACOKINETIC STUDIES; PLASMA CONCENTRATION; RUNTIMES; STABILITY TESTS; TABLET FORMULATIONS; TIME CURVES;

ACETIC ACID; CHROMATOGRAPHY; COLLISIONAL PLASMAS; ETHERS; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORGANIC SOLVENTS; PHARMACOKINETICS; PLASMA (HUMAN); SOLVENT EXTRACTION; STANDARDS;

LIQUIDS;

ACETIC ACID; ACETONITRILE; BEZAFIBRATE; CIPROFIBRATE; DICHLOROMETHANE; ETHER; FORMIC ACID; LIPLESS; ORGANIC SOLVENT; OROXADIN; UNCLASSIFIED DRUG; WATER;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; ASSAY; BIOEQUIVALENCE; CONCENTRATION (PARAMETERS); DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG INDUCED HEADACHE; DRUG STABILITY; ENERGY; FEMALE; FOOD AND DRUG ADMINISTRATION; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIDE EFFECT; STANDARD; TANDEM MASS SPECTROMETRY; UNITED STATES; VALIDATION STUDY; VOLUNTEER;

ADOLESCENT; ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FIBRIC ACIDS; HUMANS; MALE; MIDDLE AGED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 79961010090     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.05.055     Document Type: Article

References (10)

1. Desager J.P., Horsmans Y., Vandenplas C., Harvengt C. Atherosclerosis 1996, 124:65.
2. Miller D.B., Spence J.D. Clin. Pharmacokinet. 1998, 34:155.
3. Batteridge D.J. Postgrad. Med. J. 1993, 69:42.
4. Turpin G., Bruckert E. Atherosclerosis 1996, 124:83.
5. Ferry N., Bernard N., Pozet N., Gardes E., Cuisinaud G., Labeeuw M., Zech P.Y., Sassard J. Br. J. Clin. Pharmacol. 1989, 28:675.
6. Masnatta L.D., Cuniberti L.A., Rey R.H., Werba J.P. J. Chromatogr. B Biomed. Appl. 1996, 13:437.
7. Anderson N.H., Johnston D., Vojvodic P.R. J. Pharm. Biomed. Anal. 1992, 10:501.
8. Kublin E., Kaczmarska-Graczyk B., Malanowic E., Mazurek A.P. Acta Pol. Pharm. 2010, 67:455.
9. US Food and Drug Administration (1993) 6501.
10. US Food and Drug Administration (1998) 64222.