Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies

Journal of Pharmacological and Toxicological Methods

Volumn 64, Issue 1, 2011, Pages 74-80

  Lynch, James J ^a   Castagné, Vincent ^b   Moser, Paul C ^b   Mittelstadt, Scott W ^a  

^a ABBOTT LABORATORIES   (United States)

^b Porsolt SAS   (France)

Author keywords

Actimeter; Central nervous system; Irwin test; LABORAS; Locomotor activity; Rat

Indexed keywords

CAFFEINE; CHLORPROMAZINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AUTOMATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG SAFETY; EXCITATION; INFRARED RADIATION; INTERMETHOD COMPARISON; LOCOMOTION; MALE; NONHUMAN; PHARMACOLOGICAL SCIENCE; RADIATION DETECTOR; RAT; REARING; SAFETY PHARMACOLOGY; SEDATION; SENSITIVITY ANALYSIS; VIBRATION;

ANIMALS; CAFFEINE; CHLORPROMAZINE; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; TOXICITY TESTS;

RATTUS; RODENTIA;

EID: 79961007986     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2011.03.003     Document Type: Article

References (16)

1. Anon ICHS7A: Safety pharmacology studies for human pharmaceuticals. Federal Register 2001, 66:36791-36792.
2. Curry S.H., D'Mello A., Mould G.P. Destruction of chlorpromazine during absorption in the rat in vivo and in vitro. British Journal of Pharmacology 1971, 42:403-411.
3. Ilbäck N.-G., Siller M., Stålhandske T. Evaluation of cardiovascular effects of caffeine using telemetric monitoring in the conscious rat. Food and Chemical Toxicology 2007, 45:834-842.
4. Irwin S. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia 1968, 13:222-257.
5. Lynch J.J., Mittelstadt S.W. Can locomotor screening be utilized as a first-tiered approach for pre-clinical CNS/neurobehavioral safety testing?. Journal of Pharmacological and Toxicological Methods 2009, 60:232.
6. McCann F.E., Palfreeman A.C., Andrews M., Perocheau D.P., Inglis J.J., Schafer P., et al. Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Arthritis Research & Therapy 2010, 12:R107.
7. Menniti F.S., Baum M.J. Differential effects of estrogen and androgen on locomotor activity induced in castrated male rats by amphetamine, a novel environment, or apomorphine. Brain Research 1981, 216:89-107.
8. Moscardo E., Maurin A., Dorigatti R., Champeroux P., Richard S. An optimized methodology for the neurobehavioral assessment in rodents. Journal of Pharmacological and Toxicological Methods 2007, 56:239-255.
9. Porsolt D.R., Dürmüller N., Castagné V., Moser P. CNS safety pharmacology. Nonclinical Drug Safety Assessment - Practical Considerations for Successful Registration 2007, 141-162. FDANews, Washington, DC. W.K. Sietsema, R. Schwen (Eds.).
10. Quinn L.P., Grundy R.I., Campbell C.A., Collier S., Lawman A., Stean T.O., et al. A novel behavioural registration system LABORAS™ and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat. Brain Research 2005, 1031:118-124.
11. Quinn L.P., Stean T.O., Chapman H., Brown M., Vidgeon-Hart M., Upton N., et al. Further validation of LABORAS™ using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration. Journal of Neuroscience Methods 2006, 156:218-227.
12. Quinn L.P., Stean T.O., Trail B., Duxon M.S., Stratton S.C., Billinton A., et al. LABORAS™: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour. Journal of Neuroscience Methods 2003, 130:83-92.
13. Redfern W.S., Strang I., Storey S., Heys C., Barnard C., Lawton K., et al. Spectrum of effects detected in the rat functional observational battery following oral administration of non-CNS targeted compounds. Journal of Pharmacological and Toxicological Methods 2005, 52:77-82.
14. Van de Weerd H.A., Bulthuis R.J.A., Bergman A.F., Schlingmann F., Tolboom J., Van Loo P.L.P., et al. Validation of a new system for the automatic registration of behaviour in mice and rats. Behavioural Processes 2001, 53:11-20.
15. Wang Y., Lau C.E. Caffeine has similar pharmacokinetics and behavioral effects via the IP and PO routes of administration. Pharmacology Biochemistry and Behavior 1998, 60:271-278.
16. Wood N.I., Goodman A.O.G., van der Burg J.M.M., Gazeau V., Brundin P., Björkqvist M., et al. Increased thirst and drinking in Huntington's disease and the R6/2 mouse. Brain Research Bulletin 2008, 76:70-79.