The effect of antiepileptic drugs on coagulation and bleeding in the perioperative period of epilepsy surgery: The Cleveland Clinic experience

Journal of Clinical Neuroscience

Volumn 18, Issue 9, 2011, Pages 1180-1184

  Manohar, Crystal ^a   Avitsian, Rafi ^a   Lozano, Sara ^b   Gonzalez Martinez, Jorge ^a   Cata, Juan P ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Antiepileptic drugs; Blood transfusion; Coagulopathy; Epilepsy surgery; Intraoperative bleeding

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; FRESH FROZEN PLASMA; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PREGABALIN; TOPIRAMATE; VALPROIC ACID;

ADOLESCENT; ARTICLE; BLEEDING; BLEEDING DISORDER; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; BRAIN SURGERY; CRANIOTOMY; CRYOPRECIPITATE; DRUG EFFECT; EPILEPSY; ERYTHROCYTE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PERIOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION;

ADOLESCENT; ANTICONVULSANTS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; CHILD; CRANIOTOMY; EPILEPSY; FEMALE; HEMORRHAGE; HUMANS; MALE; PERIOPERATIVE PERIOD; PLATELET COUNT; RETROSPECTIVE STUDIES;

EID: 79961007494     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2011.02.018     Document Type: Article

References (28)

1. Finsterer J, Pelzl G, Hess B. Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate. Psychiatry Clin Neurosci 2001;55:423-6. (Pubitemid 32776827)
2. Holtzer CD, Reisner-Keller LA. Phenytoin-induced thrombocytopenia. Ann Pharmacother 1997;31:435-7. (Pubitemid 27155247)
3. Gerstner T, Teich M, Bell N, et al. Valproate-associated coagulopathies are frequent and variable in children. Epilepsia 2006;47:1136-43. (Pubitemid 44086748)
4. Gidal B, Spencer N, Maly M, et al. Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration. Neurology 1994;44:1418-22. (Pubitemid 24247429)
5. Tetzlaff JE. Intraoperative defect in haemostasis in a child receiving valproic acid. Can J Anaesth 1991;38:222-4.
6. Kreuz W, Linde R, Funk M, et al. Valproate therapy induces von Willebrand disease type I. Epilepsia 1992;33:178-84.
7. Zeller JA, Schlesinger S, Runge U, et al. Influence of valproate monotherapy on platelet activation and hematologic values. Epilepsia 1999;40:186-9. (Pubitemid 29066303)
8. Pan CF, Shen MY, Wu CJ, et al. Inhibitory mechanisms of gabapentin, an antiseizure drug, on platelet aggregation. J Pharm Pharmacol 2007;59:1255-61.
9. Boon P, Hulhoven R, Offner F. Levetiracetam and bleeding disorders. Acta Neurol Belg 2007;107:97-102. (Pubitemid 351447420)
10. Chambers HG, Weinstein CH, Mubarak SJ, et al. The effect of valproic acid on blood loss in patients with cerebral palsy. J Pediatr Orthop 1999;19:792-5.
11. Koenig S, Gerstner T, Keller A, et al. High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study. Blood Coagul Fibrinolysis 2008;19:375-82.
12. Anderson GD, Lin YX, Berge C, et al. Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment. J Neurosurg 1997;87:252-6. (Pubitemid 27349110)
13. Flack S, Ojemann J, Haberkern C. Cerebral hemispherectomy in infants and young children. Paediatr Anaesth 2008;18:967-73.
14. Jalilian L, Limbrick DD, Steger-May K, et al. Complete versus anterior two-thirds corpus callosotomy in children: analysis of outcome. J Neurosurg Pediatr 2010;6:257-66.
15. Innerhofer P, Kienast J. Principles of perioperative coagulopathy. Best Pract Res Clin Anaesthesiol 2010;24:1-14.
16. Kor DJ, Stubbs JR, Gajic O. Perioperative coagulation management-fresh frozen plasma. Best Pract Res Clin Anaesthesiol 2010;24:51-64.
17. Ward MM, Barbaro NM, Laxer KD, et al. Preoperative valproate administration does not increase blood loss during temporal lobectomy. Epilepsia 1996;37:98-101. (Pubitemid 26021584)
18. Tanindi S, Akin R, Koseoglu V, et al. The platelet aggregation in children with epilepsy receiving valproic acid. Thromb Res 1996;81:471-6. (Pubitemid 26100414)
19. Verrotti A, Greco R, Matera V, et al. Platelet count and function in children receiving sodium valproate. Pediatr Neurol 1999;21:611-4. (Pubitemid 29460993)
20. Kozek-Langenecker SA. Perioperative coagulation monitoring. Best Pract Res Clin Anaesthesiol 2010;24:27-40.
21. Tice DA, Reed GE, Clauss RH, et al. Hemorrhage due to fibrinolysis occurring with open-heart operations. J Thorac Cardiovasc Surg 1963;46:673-9.
22. Dragoni F, Mazzucconi MG, Acqui M, et al. Coagulation study in patients who had undergone surgery for meningioma. Haemostasis 1993;23:301-7. (Pubitemid 24153319)
23. Schmotzer CL, Brown AE, Roth S, et al. Procedure-specific preoperative red blood cell preparation and utilization management in pediatric surgical patients. Transfusion 2010;50:861-7.
24. Gowda S, Salazar F, Bingaman WE, et al. Surgery for catastrophic epilepsy in infants 6 months of age and younger. J Neurosurg Pediatr 2010;5:603-7.
25. Piastra M, Pietrini D, Caresta E, et al. Hemispherectomy procedures in children: haematological issues. Childs Nerv Syst 2004;20:453-8. (Pubitemid 39077350)
26. Koubeissi MZ, Syed TU, Syed I, et al. Hemispherectomy-associated complications from the Kids' Inpatient Database. Epilepsy Res 2009;87:47-53.
27. Basheer SN, Connolly MB, Lautzenhiser A, et al. Hemispheric surgery in children with refractory epilepsy: seizure outcome, complications, and adaptive function. Epilepsia 2007;48:133-40. (Pubitemid 46096035)
28. de Almeida AN, Marino Jr R, Marie SK, et al. Factors of morbidity in hemispherectomies: surgical technique x pathology. Brain Dev 2006;28:215-22.