Antibiotic use for presumed neonatally acquired infections far exceeds that for central line-associated blood stream infections: An exploratory critique

Journal of Perinatology

Volumn 31, Issue 8, 2011, Pages 514-518

  Wirtschafter, D D ^a   Padilla, G ^b   Suh, O ^b   Wan, K ^c   Trupp, D ^c   Simon Fayard, E E ^c  

^a David D Wirtschafter MD Inc   (United States)

^b MILLER CHILDREN S HOSPITAL   (United States)

^c LOMA LINDA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

antibiotic stewardship; central line associated blood stream infection; neonatal antibiotic use; presumed neonatal infection

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC THERAPY; ARTICLE; CATHETER INFECTION; CLINICAL ASSESSMENT; COHORT ANALYSIS; DRUG USE; FEMALE; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; NEWBORN; NEWBORN INFECTION; NEWBORN INTENSIVE CARE; NEWBORN SEPSIS; PERINATAL INFECTION;

ANTI-BACTERIAL AGENTS; BACTEREMIA; CATHETERIZATION, CENTRAL VENOUS; CATHETERS, INDWELLING; CROSS INFECTION; DRUG UTILIZATION; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; PHYSICIAN'S PRACTICE PATTERNS; QUALITY INDICATORS, HEALTH CARE;

EID: 79961002448     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/jp.2011.39     Document Type: Article

References (38)

1. Grohskopf LA, Huskins WC, Sinkowitz-Cochran RL, Levine GL, Goldmann DA, Jarvis WR. Pediatric Prevention Network: use of antimicrobial agents in United States neonatal and pediatric intensive care patients. Pediatr Infect Dis J 2005; 24: 766-773. (Pubitemid 41324883)
2. Patel SJ, Oshodi A, Prasad P, Delamora P, Larson E, Zaoutis T et al. Antibiotic use in neonatal intensive care units and adherence with Centers for Disease Control and Prevention 12 Step Campaign to prevent antimicrobial resistance. Pediatr Infect Dis J 2009; 28: 1047-1051.
3. Wirtschafter DD, Pettit J, Kurtin P, Dalsey M, Chance K, Morrow HW et al. A statewide quality improvement collaborative to reduce neonatal central line-associated blood stream infections. J Perinatology 2010; 30: 170-181.
4. Hammerschlag MR, Klein JO, Herschel M, Chen FC, Fermin R. Patterns of use of antibiotics in two newborn nurseries. N Engl J Med 1977; 296: 1268-1269. (Pubitemid 8123915)
5. Centers for Disease Control and Prevention, The National Healthcare Safety Network (NHSN). Guidelines and Procedures for Monitoring CLABSI: Central Line-Associated Bloodstream Infection (CLABSI) Event. Atlanta: GA, 2010: Available at: http://www.cdc.gov/nhsn/PDFs/pscManual/4PSC-CLABScurrent.pdflast accessed 12-11-2010.
6. Baltimore RS. The difficulty of diagnosing ventilator-associated pneumonia. Pediatrics 2003; 112: 1420-1421. (Pubitemid 37523430)
7. Srinivasan PS, Brandler MD, D'Souza A. Necrotizing enterocolitis. Clin Perinatol 2008; 35: 251-272. (Pubitemid 351246701)
8. Randolph AG, Brun-Buisson C, Goldman D. Identification of central venous catheter-related infections in infants and children. Pediatr Crit Care Med 2005; 6(3 Suppl): S19-S24. (Pubitemid 40724247)
9. Perlman SE, Saiman L, Larson EL. Risk factors for late-onset health care-associated bloodstream infections in patients in neonatal intensive care units. Am J Infect Control 2007; 35: 177-182. (Pubitemid 46551322)
10. Haque KN. Defining common infections in children and neonates. J Hosp Infect 2007; 65(Suppl 2): 110-114. (Pubitemid 46805848)
11. Gerdes JS. Diagnosis and management of bacterial infections in the neonate. Pediatr Clin North Am 2004; 51: 939-959. (Pubitemid 38962677)
12. Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health, Version 2.3. www.OpenEpi.com, updated 2009/20/05, accessed 2010/06/17.
13. Powers RJ, Wirtschafter DD. Decreasing central line associated bloodstream infection in neonatal intensive care. Clin Perinatol 2010; 37: 247-272.
14. Cotton C, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sánchez PJ et al. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low bith weight infants. Pediatrics 2009; 123: 58-66.
15. Fischer JE, Bachmann LM, Jaeschke R. A readers' guide to the interpretation of diagnostic test properties: clinical example of sepsis. Intensive Care Med 2003; 29: 1043-1051. (Pubitemid 36918544)
16. Glas AS, Lijmer JG, Prins MH, Bonsel GJ, Bossuyt PM. The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol 2003; 56: 1129-1135. (Pubitemid 37386338)
17. Reitsma JB, Glas AS, Rutjes AW, Scholten RJ, Bossuyt PM, Zwinderman AH. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol 2005; 58: 982-990. (Pubitemid 41316441)
18. Van den Bruel A, Cleemput I, Aertgeerts B, Ramaekers D, Buntinx F. The evaluation of diagnostic tests: evidence on technical and diagnostic accuracy, impact on patient outcome and cost-effectiveness is needed. J Clin Epidemiol 2007; 60: 1116-1122. (Pubitemid 47552765)
19. Lijmer JG, Mol BW, Heisterkamp S, Bonsel GJ, Prins MH, van der Meulen JH et al. Empirical evidence of design-related bias in studies of diagnostic tests. JAMA 1999; 282: 1061-1066. (Pubitemid 29436454)
20. Deeks JJ. Systematic reviews in health care: Systematic reviews of evaluations of diagnostic and screening tests. BMJ 2001; 323(7305): 157-162. (Pubitemid 32678396)
21. Buttery JP. Blood cultures in newborns and children-optimizing an everyday test. Arch Dis Child Fetal Neonatal ED 2002; 87: F25-F28. (Pubitemid 34753792)
22. Connell TG. How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children's hospital. Pediatrics 2007; 119: 891-896. (Pubitemid 46715658)
23. Falagas ME, Kazantzi MS, Bliziotis JA. Comparison of utility of blood cultures from intravascular catheters and peripheral veins: a systematic review and decision analysis. J Med Microbiol 2008; 57: 1-8.
24. Kellogg JA, Ferrentino FL, Goodstein MH, Liss J, Shapiro SL, Bankert DA. Frequency of low-level bacteriemia in infants from birth to two months of age. Pediatr Infect Dis J 1997; 16: 381-385. (Pubitemid 27172958)
25. Schelonka RL, Chai MK, Yoder BA, Hensley D, Brockett RM, Ascher DP. Volume of blood required to detect common neonatal pathogens. J Pediatr 1996; 129: 275-278. (Pubitemid 27483801)
26. Isaacman DJ, Karasic RB, Reynolds EA, Kost SI. Effect of number of blood cultures and volume of blood on detection of bacteremia in children. J Pediatr 1996; 128: 190-195. (Pubitemid 26065941)
27. Mermel LA, Maki DG. Detection of bacteremia in adults: consequences of culturing an inadequate volume of blood. Ann Intern Med 1993; 119: 270-272. (Pubitemid 23319882)
28. Harris H, Wirtschafter D, Cassady G. Endotracheal intubation and its relationship to bacterial colonization and systemic infection of newborn infants. Pediatrics 1976; 58(6): 816-823. (Pubitemid 8000133)
29. Sherman MP, Goetzman BW, Ahlfors CE, Wennberg RP. Tracheal asiration and its clinical correlates in the diagnosis of congenital pneumonia. Pediatrics 1980; 65: 258-263. (Pubitemid 10068584)
30. Jordan JA. Molecular diagnosis of neonatal sepsis. Clin Perinatol 2010; 37: 411-419.
31. McBryde ES, Brett J, Russo PL, Worth LJ, Bull AL, Richards MJ. Validation of statewide surveillance system data on central line-associated bloodstream infection in intensive care units in Australia. Infect Control Hosp Epidemiol 2009; 30: 1045-1049.
32. Lin MY, Hota B, Khan YM, Woeltje KF, Borlawsky TB, Doherty JA et al. Quality of traditional surveillance for public reporting of nosocomial bloodstream infection rates. JAMA 2010; 304(18): 2035-2041.
33. Fischer JE, Seifarth FG, Baenziger O, Fanconi S, Nadal D. Hindsight judgment on ambiguous episodes of suspected infection in critically ill children: Poor consensus amongst experts? Eur J Pediatr 2003; 162: 840-843. (Pubitemid 37523832)
34. Fischer JE, Harbarth S, Agthe AG, Benn A, Ringer SA, Goldmann DA et al. Quantifying uncertainty: physicians' estimates of infection in critically ill neonates and children. Clin Infect Dis 2004; 38: 1383-1390. (Pubitemid 38668583)
35. Okascharoen C, Hui C, Cairnie J, Morris AM, Kirpalani H. External validation of bedside prediction score for diagnosis of late-onset neonatal sepsis. J Perinatol 2007; 27: 496-501. (Pubitemid 47180411)
36. Sarkar S, Bhagat I, DeCristofaro JD, Wiswell TE, Spitzer AR. A study of the role of multiple site blood cultures in the evaluation of neonatal sepsis. J Perinatol 2006; 26: 18-22. (Pubitemid 43135250)
37. Modi N, Doré CJ, Saraswatula A, Richards M, Bamford KB, Coello R et al. A case definition for national and international neonatal bloodstream infection surveillance. Arch Dis Child Fetal Neonatal Ed 2009; 94: F8-F12.
38. Stark AR. American Academy of Pediatrics Committee on Fetus and Newborn. Levels of care. Pediatrics 2004; 114: 1341-1347.