Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans

Journal of Clinical Investigation

Volumn 121, Issue 8, 2011, Pages 3094-3099

  Van Oudenhove, Lukas ^a,b   McKie, Shane ^b   Lassman, Daniel ^b   Uddin, Bilal ^b   Paine, Peter ^b   Coen, Steven ^c   Gregory, Lloyd ^b   Tack, Jan ^a   Aziz, Qasim ^b,c  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID;

ANTERIOR CINGULATE; ARTICLE; BOLD SIGNAL; BRAIN LEVEL; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; EMOTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GUT BRAIN SIGNALING; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; HUNGER; HYPOTHALAMUS; MEDULLA OBLONGATA; MESENCEPHALON; MOOD; NAUSEA; NORMAL HUMAN; POSTERIOR CINGULATE; PRIORITY JOURNAL; SEX DIFFERENCE; SIGNAL TRANSDUCTION; THALAMUS;

BEHAVIOR; BRAIN; BRAIN MAPPING; EATING; EMOTIONS; FACIAL EXPRESSION; FATTY ACIDS; FEEDING BEHAVIOR; HUMANS; HUNGER; INTESTINES; MAGNETIC RESONANCE IMAGING; NEURONS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 79960995583     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI46380     Document Type: Article

References (22)

1. Gibson EL. Emotional influences on food choice: Sensory, physiological and psychological pathways. Physiol Behav. 2006;89(1):53-61.
2. Saper CB, Chou TC, Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron. 2002;36(2):199-211. (Pubitemid 35217887)
3. Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3(8):655-666. (Pubitemid 135706673)
4. Rolls ET. Understanding the mechanisms of food intake and obesity. Obes Rev. 2007;8 suppl 1:67-72.
5. Zagon A. Does the vagus nerve mediate the sixth sense? Trends Neurosci. 2001;24(11):671-673. (Pubitemid 33152775)
6. Kringelbach ML. The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 2005;6(9):691-702. (Pubitemid 43160318)
7. Rolls ET. Brain mechanisms underlying flavour and appetite. Philos Trans R Soc Lond B Biol Sci. 2006;361(1471):1123-1136. (Pubitemid 44874224)
8. Vaidya V. Psychosocial aspects of obesity. Adv Psychosom Med. 2006;27:73-85. (Pubitemid 43264894)
9. Fox JRE, Power MJ. Eating disorders and multilevel models of emotion: An integrated model. Clin Psychol Psychother. 2009;16(4):240-267.
10. Van Oudenhove L, Aziz Q. Recent insights on central processing and psychological processes in functional gastrointestinal disorders. Dig Liver Dis. 2009;41(11):781-787.
11. Andréasson A, Arborelius L, Erlanson-Albertsson C, Lekander M. A putative role for cytokines in the impaired appetite in depression. Brain Behav Immun. 2007;21(2):147-152. (Pubitemid 46038915)
12. Lassman DJ, et al. Defining the role of cholecystokinin in the lipid-induced human brain activation matrix. Gastroenterology. 2010;138(4):1514-1524.
13. Kober H, et al. Functional grouping and corticalsubcortical interactions in emotion: A meta-analysis of neuroimaging studies. NeuroImage. 2008;42(2): 998-1031.
14. Hepworth R, Mogg K, Brignell C, Bradley BP. Negative mood increases selective attention to food cues and subjective appetite. Appetite. 2010;54(1):134-142.
15. Spoor STP, Bekker MHJ, Van Strien T, van Heck GL. Relations between negative affect, coping, and emotional eating. Appetite. 2007;48(3):368-376. (Pubitemid 46413410)
16. Horvitz JC. Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience. 2000;96(4):651-656. (Pubitemid 30155729)
17. Damasio AR, et al. Subcortical and cortical brain activity during the feeling of self-generated emotions. Nat Neurosci. 2000;3(10):1049-1056.
18. Mitterschiffthaler MT, Fu CHY, Dalton JA, Andrew CM, Williams SCR. A functional MRI study of happy and sad affective states induced by classical music. Hum Brain Mapp. 2007;28(11):1150-1162. (Pubitemid 350077480)
19. Ekman P, Friesen WV. Pictures Of Facial Affect. Palo Alto, California, USA: Consulting Psychologists Press; 1975.
20. McKie S, et al. Neuronal effects of acute citalopram detected by pharmacoMRI. Psychopharmacology. 2005;180(4):680-686. (Pubitemid 41317864)
21. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage. 2003;19(3):1233-1239. (Pubitemid 36918259)
22. Brett M, Anton J-L, Valabregue R, Poline J-B. Region of interest analysis using an SPM toolbox. NeuroImage. 2002;16:1141-1142.