The role of Natural Killer T (NKT) cells in the pathogenesis of type 1 diabetes

Current Diabetes Reviews

Volumn 7, Issue 4, 2011, Pages 278-283

  Gómez Díaz, Rita A ^a   Aguilar, Mayra V ^a   Meguro, Elisa N ^b   Márquez, Rocío H ^b   Magaña, Eulalia G ^b   Martinez Garcia, M Carmen ^a   Rodarte, Niels W ^a   Aguilar Salinas, Carlos A ^d   Canché Pool, Elsy ^c   Ortiz Navarrete, Vianney ^c  

^a HOSPITAL DE ESPECIALIDADES   (Mexico)

^b HOSPITAL DE PEDIATRÍA   (Mexico)

^c DEPARTAMENTO DE FÍSICA   (Mexico)

^d INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

Class I MHC restricted T cell associated molecule (CRTAM); Natural Killer T (NKT) cells; Type 1 diabetes

Indexed keywords

CYTOKINE; T LYMPHOCYTE RECEPTOR;

ARTICLE; AUTOIMMUNE DISEASE; CELL FUNCTION; CELL POPULATION; DISEASE ASSOCIATION; DISEASE COURSE; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AUTOIMMUNITY; DIABETES MELLITUS, TYPE 1; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MODELS, BIOLOGICAL; NATURAL KILLER T-CELLS; T-CELL ANTIGEN RECEPTOR SPECIFICITY;

EID: 79960988726     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/157339911796397839     Document Type: Article

References (67)

1. Phillips JM, Parish NM, Bland C, Sawyer Y, De la Peña H, Cooke A. Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both cell populations. Rev Diabet Stud 2009; 6: 97-103.
2. Kay TW, Thomas HE, Harrison LC, Allison J. The beta cell in autoimmune diabetes: many mechanisms and pathways of loss. Trens Endocrinol Metab 2000; 11: 11-5.
3. Delovitch TL, Singh B. The nonobese diabetic mouse as a model of autoimmune disease: immune dysregulation gets the NOD. Immunity 1997; 7: 727-38.
4. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol 2007; 25: 297-336.
5. Colonna M, Jonjic S, Watzl C. Natural killer cells: fighting viruses and much more. Nat Immunol 2011; 12: 107-10.
6. Eizirik DL, Colli ML, Ortiz F. The role of inflammation in insulitis and cell loss in type 1 diabetes. Nat Rev Endocrinol 2009; 5: 219-226.
7. Lehuen A, Diana J, Zaccone P, Cooke A. Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol 2010; 10: 501-13.
8. Kelly MA, Mijovic CH, Barnett AH. Genetics of type 1 diabetes. Best Pract Res Clin Endocrinol Metab 2001; 15: 279-91.
9. Eisenbarth GS. Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes. Diabetes 2010; 59: 759-74.
10. Stadinski BD, Zhang L, Crawford F, et al. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. PNAS 2010; 107: 10978-83.
11. Kataoka S, Satoh J, Toyota T, et al. Immunologic aspects of the nonobese diabetic (NOD) mouse. Abnormalities of cellular immunity. Diabetes 1983; 32: 247-53.
12. Undlien DE, Lie BA, Thorsby E. HLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved? Trends Genet 2001; 17: 93-100.
13. Barret JC, Clayton DG, Concannon P, et al. Genome-wide associa-tion study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009; 41: 703-7.
14. Erlich H, Valdes AM, Noble J, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008; 57: 1084-92.
15. Aly TA, Ide A, Jahromi MM, et al. Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci USA 2006; 103: 14074-14079.
16. Erlich HA, Zeidler A, Chang J, et al. HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families. Nat Genet 1993; 3: 358-64.
17. Godoresky C, Olivares A, Debezo H, Rodriguez L, Altamirano N, Robles C. MHC-dependent molecular mechanisms of susceptibility and protection in type 1 diabetes in mexicans. Gac Med Mex 1995; 131: 395-402.
18. Nejentsev S, Howson JM, Walker NM, et al. Wellcome Trust Case Control Consortium. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007; 450: 887-92.
19. Pugliese A, Miceli D. The insulin gene in diabetes. Diabetes Metab Res Rev 2002; 18: 13-25.
20. Bottini N, Musumeci L, Alonso A, et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 2004; 36: 337-8.
21. Ueda H, Howson JMM, Esposito L, et al. Association of the T cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003; 423: 506-11.
22. Knip M, Virtanen SM, Sepp K, et al. Finnish TRIGR Study Group. Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med 2010; 363: 1900-8.
23. Poole JA, Barriga K, Leung DY, et al. Timing of initial exposure to cereal grains and the risk of wheat allergy. Pediatrics 2006; 117: 2175-82.
24. Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 2003; 290: 1721-28.
25. Stene LC, Joner G: Norwegian Childhood Diabetes Study Group. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population- based, case-control study. Am J Clin Nutr 2003; 78: 1128-34.
26. Law GR, McKinney PA, Staines A, et al. Clustering of childhood IDDM. Links with age and place of residence. Diabetes Care 1997; 20: 753-6.
27. Blom L, Dahlquist G, Nystrom L, Sandstrom A, Wall S. The Swed-ish childhood diabetes study-social and perinatal determinants for diabetes in childhood. Diabetologia 1989; 32: 7-13.
28. Yeun WC, Rawlinson WD, Craig ME. Enterovirus infection and type 1 diabetes: systematic review and meta-analysis of observational molecular studies. BMJ 2011; 342: d35.
29. Rewers M, Barriga K, Baxter J, et al. TEDDY Study Groop. The environmental determinants of diabetes in the young (TEDDY) Study. Ann N Y Acad Sci 2008; 1150: 1-13.
30. Verge CF, Gianani R, Kawasaki E, et al. Prediction of type I diabe-tes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 1996; 45: 926-33.
31. Wenzlau JM, Juhl K, Yu L, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2007; 104: 17040-17045
32. Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigssojn J, Lenrmark. A. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 1982; 298: 167-9.
33. Zhang L, Eisenbarth GS. Prediction and prevention of type 1 diabe-tes mellitus. J Diabetes 2011; 1: 48-57.
34. Leisle D, Lipsky P, Notkins AL. Autoantibodies as predictors of disease. J Clin Invest 2001; 108: 1417-22.
35. Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations. Ann Rev Immunol 2010; 28: 445-89.
36. Godfrey DI, Hammond KJL, Poulton LD, Smyth MJ, Baxter AG. NKT cells: facts, functions and fallacies. Immunol Today 2000; 21: 573-83.
37. Brigl M, Brenner MB. CD1: antigen presentation and T cell func-tion. Annu Rev Immunol 2004; 22: 817-90.
38. Borg NA, Wun KS, Kjer-Nielsen L, et al. CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature 2007; 448: 44-9.
39. Gumperz JE, Miyake S, Yamamura T, Brenner MB. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 2002: 195: 625-36.
40. Lee PT, Benlagha K, Teyton L, Bendelac A. Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med 2002; 195: 63-41.
41. Takahashi T, Chiba S, Nieda M, et al. Cutting edge: analysis of human V alpha 24+CD8+ NKT cells activated by alphagalactosyl- ceramide-pulsed monocyte-derived dendritic cells. J Immunol 2002; 168: 3140-4
42. Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Van Kaer L. NK T cells: What's in a name? Nat Rev Immunol 2004; 4: 231-7.
43. Fowlkes BJ, Kruisbeek AM, Ton-That H, et al. A novel population of T-cell receptor -bearing thymocytes which predominantly expresses a single V gene family. Nature 1987; 329: 251-4.
44. Budd RC, Miescher GC, Howe RC, Lees RK, Bron C, MacDonald HR. Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes. J Exp Med 1987; 166: 577-82.
45. Porcelli S, Yockey CE, Brenner MB, Balk SP. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- T cells demonstrates preferential use of several Vß genes and an invariant TCR chain. J Exp Med 1993; 178: 1-16.
46. Lantz O, Bendelac A. An invariant T cell receptor chain is used by a unique subset of MHC class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med 1994; 180: 1097-106.
47. Sharif S, Arreaza GA, Zucker P, Mi QS, Delovitch TL. Regulation of autoimmune disease by natural killer T cells. J Mol Med 2002; 80: 290-300.
48. Ambrosino E, Berzofky JA, Terabe M. Regulation of tumor immu-nity: the role of NKT cells. Expert Opin Biol Ther 2008; 8: 725-34.
49. Baxter AG, Kinder SJ, Hammond KJ, Scollay R, Godfrey DI. Association between alphabeta TCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 1997; 46: 572-82.
50. Poulton LD, Smyth MJ, Hawke CG, et al. Cytometric and func-tional analyses of NK and NKT cell deficiencies in NOD mice. Int Immunol 2001; 13: 887-96.
51. Moitard C, Yasunami R, Dardenne M, et al. T cell-mediated inhibi-tion of the transfer of autoimmune diabetes NOD mice. J Exp Med 1989; 169: 1669-80.
52. Lehuen A, Lantz O, Beaudoin L, et al. Over expression of natural killer T cells protects Va14-Ja281 transgenic nonobese mice against diabetes. J Exp Med 1998; 188: 1831-9.
53. Wang B, Geng YB, Wnag CR. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J Exp Med 2000; 194: 313-19.
54. ] Yang Y, Bao M, Yoon JM. Intrinsic defects in the T-cell lineage results in natural killer T-cell deficiency and the development of diabetes in the nonobese diabetic mouse Diabetes 2001; 50: 2691-2699
55. Dardenne M, Lepault FB, Bach JF. Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning. Eur J Immunol 1989; 9: 889-95.
56. Wagner MJ, Hussain S, Mehan M, et al. A defect in lineage fate decision during fetal thymic invariant NKT cell development may regulate susceptibility to type 1 diabetes. J Immunol 2005; 174: 6764-71.
57. Wilson SB, Kemt SC, Patton KT, et al. Extreme Th1 bias of invari-ant V 24J Q T cells in type 1 diabetes. Nature 1998; 391: 177-81.
58. Kukreja A, Cost G, Marker J, et al. Multiple immuno-regulatory defects in type 1 diabetes. J Clin Invest 2002; 109: 131-40.
59. Oikawa Y, Shimada A, Yamada S, et al. NKT cell frequency in Japanese type 1 diabetes. Ann NY Acad Sci 2003; 1005: 230-2
60. Oikawa Y, Shimida A, Yamada S, et al. High frequency of V 24 V 11 T-cells observed in type 1 diabetes. Diabetes Care 2002; 25: 1818-23.
61. Lee PT, Putnam A, Benlagha K, et al. Testing the NKT Cell hy-pothesis of human IDDM pathogenesis. J Clin Invest 2002; 110: 793-800.
62. Jordan MA, Fletcher J, Baxter A. Genetic control of NKT cell numbers. Immunol Cell Biol 2004; 82: 276-84.
63. Kennedy J, Vicari AP, Saylor V, et al. A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). J Leukoc Biol 2000; 67: 725-34.
64. Valle-Rios R, Patiño-Lopez G, Medina-Contreras O, et al. Charac-terization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes. Mol Immunol 2009; 46: 3379-87.
65. Arase N, Takeuchi A, Unno M, et al. Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells. Int Immunol 2005; 17: 1227-37.
66. Patiño-Lopez G Hevezi, P. Lee, J et al. Human class-I restricted T cell associated molecule is highly expressed in the cerebrum and is a marker for activated NKT and CD8+T lymphocytes. J Neuroimmunol 2006; 171: 145-55.
67. Ortiz-Navarrete V, Canche-Pool E, Gómez-Díaz R, et al. CRTAM molecule is expressed at the cell surface of NKT cells from patients with type 1 diabetes mellitus. Clin Immunol 2009; 131: S145.