Pharyngeal airway protective reflexes are triggered before the maximum volume of fluid that the hypopharynx can safely hold is exceeded

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 2, 2011, Pages

  Dua, Kulwinder ^a   Surapaneni, Sri Naveen ^a   Kuribayashi, Shiko ^a   Hafeezullah, Muhammad ^a   Shaker, Reza ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aerodigestive reflexes; Airway protection; Hypopharyngeal safe volume; Pharyngo glottal closure reflex; Pharyngo upper esophageal sphincter contractile reflex; Reflexive pharyngeal swallow

Indexed keywords

WATER;

ADOLESCENT; ADULT; AIRWAY; ANESTHESIA; ARTICLE; BODY FLUID; DIGESTION; FEMALE; FLUID INTAKE; GLOTTIS; HUMAN; HUMAN EXPERIMENT; HYPOPHARYNX; INFUSION; INJECTION; LARYNGOSCOPY; LARYNX; MALE; MANOMETRY; NORMAL HUMAN; PERISTALSIS; PHARYNGO UPPER ESOPHAGEAL SPHINCTER CONTRACTILE REFLEX; PHARYNGOGLOTTAL CLOSURE REFLEX; PHARYNGOLARYNGOSCOPY; PHARYNX; PRIORITY JOURNAL; REFLEXIVE PHARYNGEAL SWALLOW; SWALLOWING; UPPER ESOPHAGUS SPHINCTER;

ADOLESCENT; ADULT; DEGLUTITION; ESOPHAGEAL SPHINCTER, UPPER; FEMALE; HUMANS; HYPOPHARYNX; MALE; MANOMETRY; REFLEX; RESPIRATORY ASPIRATION; SENSORY THRESHOLDS; WATER; YOUNG ADULT;

EID: 79960986585     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00046.2011     Document Type: Article

References (17)

1. Bajaj JS, Dua K, Bajaj S, Rittmann T, Shaker R. Effect of infusion rate on elicitation of pharyngeal reflexes and development of aspiration among smokers (Abstract). Neurogastroenterol Motil 16: 672, 2004.
2. Dua K, Bardan E, Ren J, Sui Z, Shaker R. Effect of chronic and acute cigarette smoking on the pharyngo-upper oesophageal sphincter contractile reflex and reflexive pharyngeal swallow. Gut 43: 537-541, 1998.
3. Dua K, Bardan E, Ren J, Sui Z, Shaker R. Effect of chronic and acute cigarette smoking on the pharyngoglottal closure reflex. Gut 51: 771-775, 2002.
4. Dua KS, Surapaneni SN, Santharam R, Knuff D, Hofmann C, Shaker R. Effect of systemic alcohol and nicotine on airway protective reflexes. Am J Gastroenterol 104: 2431-2438, 2009.
5. Dua KHM, Surapaneni S, Tatro L, Shaker R. Prevalence of abnormal upper GI findings in apparently healthy volunteers enrolled for research studies. Gastrointest Endosc 69: AB350-AB351, 2009.
6. Lang IM, Dana N, Medda BK, Shaker R. Mechanisms of airway protection during retching, vomiting, and swallowing. Am J Physiol Gastrointest Liver Physiol 283: G529-G536, 2002.
7. Medda BK, Lang IM, Layman R, Hogan WJ, Dodds WJ, Shaker R. Characterization and quantification of a pharyngo-UES contractile reflex in cats. Am J Physiol Gastrointest Liver Physiol 267: G972-G983, 1994.
8. Medda BK, Kern M, Ren J, Xie P, Ulualp SO, Lang IM, Shaker R. Relative contribution of various airway protective mechanisms to prevention of aspiration during swallowing. Am J Physiol Gastrointest Liver Physiol 284: G933-G939, 2003.
9. Nishino T. Swallowing as a protective reflex for the upper respiratory tract. Anesthesiology 79: 588-560, 1993.
10. Pouderoux P, Logemann J, Kahrilas P. Pharyngeal swallowing elicited by fluid infusion: role of volition and vallecular containment. Am J Physiol Gastrointest Liver Physiol 270: G347-G354, 1996.
11. Shaker R, Ren J, Zamir Z, Sarna A, Liu J, Sui Z. Effect of aging, position, and temperature on the threshold volume triggering pharyngeal swallows. Gastroenterology 107: 396-402, 1994.
12. Shaker R. Unsedated trans-nasal pharyngoesophagogastroduodenoscopy (T-EGD): technique. Gastrointest Endosc 40: 346-348, 1994.
13. Shaker R, Ren J, Xie P, Lang IM, Bardan E, Sui Z. Characterization of the pharyngo-UES contractile reflex in humans. Am J Physiol Gastrointest Liver Physiol 273: G854-G858, 1997.
14. Shaker R, Ren J, Bardan E, Easterling C, Dua K, Xie P, Kern M. Pharyngoglottal closure reflex: characterization in healthy young, elderly and dysphagic patients with predeglutitive aspiration. Gerontology 49: 12-20, 2003.
15. Surapaneni S, Dua K, Kuribayashi S. Mechanism of airway protection against aspiration of refluxate: relationship between critical volume and threshold volume (Abstract). Neurogastroenterol Motil 20: 21, 2008.
16. Surapaneni SN, Dua KS, Kuribayashi S, Hafeezullah M, Tatro L, Shaker R. Influence of position on the maximum volume of fluid that can safely dwell in the hypo-pharynx; "Hypopharyngeal Safe Volume" (HPSV) (Abstract). Gastroenterology 136: A734, 2008.
17. Surapaneni SN, Dua KS, Kuribayashi S, Hafeezullah M, Amaris MA, Shaker R. Aerodigestive protective reflexes are triggered before the safe capacity of pharynx is exceeded (Abstract). Gastroenterology 138: S13, 2010.