Smad2 and PEA3 cooperatively regulate transcription of response gene to complement 32 in TGF-β-induced smooth muscle cell differentiation of neural crest cells

American Journal of Physiology - Cell Physiology

Volumn 301, Issue 2, 2011, Pages

  Huang, Wen Yan ^a,b,c   Xie, Weibing ^a   Guo, Xia ^a   Li, Fengmin ^c   Jose, Pedro A ^c,d   Chen, Shi You ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Polyomavirus enhancer activator 3; Response gene to complement 32; Smad2; Transcriptional regulation; Transforming growth factor

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENT; SHORT HAIRPIN RNA; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; TRANSCRIPTION FACTOR PEA3; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BINDING KINETICS; BINDING SITE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; COMPLEMENT SYSTEM; CONTROLLED STUDY; DOWN REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; IMMUNE RESPONSE GENE; INHIBITION KINETICS; MOUSE; NEURAL CREST CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; RESPONSE GENE TO COMPLEMENT 32; SEQUENCE ANALYSIS; SMOOTH MUSCLE FIBER; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MUTATION; MYOCYTES, SMOOTH MUSCLE; NEURAL CREST; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

POLYOMAVIRUS;

EID: 79960980731     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00480.2010     Document Type: Article

References (38)

1. Aikawa M, Sivam PN, Kuro-o M, Kimura K, Nakahara K, Takewaki S, Ueda M, Yamaguchi H, Yazaki Y, Periasamy M, and et al. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res 73: 1000-1012, 1993.
2. An X, Jin Y, Guo H, Foo SY, Cully BL, Wu J, Zeng H, Rosenzweig A, Li J. Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation 120: 617-627, 2009.
3. Bartel FO, Higuchi T, Spyropoulos DD. Mouse models in the study of the Ets family of transcription factors. Oncogene 19: 6443-6454, 2000.
4. Briones VR, Chen S, Riegel AT, Lechleider RJ. Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta. Biochem Biophys Res Commun 345: 595-601, 2006.
5. Brown KA, Pietenpol JA, Moses HL. A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem 101: 9-33, 2007.
6. Chen S, Crawford M, Day RM, Briones VR, Leader JE, Jose PA, Lechleider RJ. RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation. J Biol Chem 281: 1765-1770, 2006.
7. Chen S, Kulik M, Lechleider RJ. Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta. Nucleic Acids Res 31: 1302-1310, 2003.
8. Chen S, Lechleider RJ. Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest stem cell line. Circ Res 94: 1195-1202, 2004.
9. Cheung TH, Barthel KK, Kwan YL, Liu X. Identifying pattern-defined regulatory islands in mammalian genomes. Proc Natl Acad Sci USA 104: 10116-10121, 2007.
10. Choudhary B, Ito Y, Makita T, Sasaki T, Chai Y, Sucov HM. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289: 420-429, 2006.
11. de Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB, Lechleider RJ. Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev 12: 1587-1592, 1998.
12. de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, Lechleider RJ. The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J Biol Chem 275: 2115-2122, 2000.
13. Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17: 3091-3100, 1998.
14. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11: 1475-1489, 1983.
15. Feinberg MW, Watanabe M, Lebedeva MA, Depina AS, Hanai J, Mammoto T, Frederick JP, Wang XF, Sukhatme VP, Jain MK. Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. J Biol Chem 279: 16388-16393, 2004.
16. Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 21: 659-693, 2005.
17. Goumans MJ, Mummery C. Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice. Int J Dev Biol 44: 253-265, 2000.
18. Guo X, Jose PA, Chen SY. Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells. Am J Physiol Cell Physiol 300: C1415-C1421, 2011.
19. Hart AH, Willson TA, Wong M, Parker K, Robb L. Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1. Biochem Biophys Res Commun 333: 1361-1369, 2005.
20. Kocher O, Gabbiani G. Cytoskeletal features of normal and atheromatous human arterial smooth muscle cells. Hum Pathol 17: 875-880, 1986.
21. Li F, Luo Z, Huang W, Lu Q, Wilcox CS, Jose PA, Chen S. Response gene to complement 32, a novel regulator for transforming growth factorbeta- induced smooth muscle differentiation of neural crest cells. J Biol Chem 282: 10133-10137, 2007.
22. Majesky MW. Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol 27: 1248-1258, 2007.
23. Martin ME, Piette J, Yaniv M, Tang WJ, Folk WR. Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins. Proc Natl Acad Sci USA 85: 5839-5843, 1988.
24. Massague J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19: 1745-1754, 2000.
25. Matsuura I, Wang G, He D, Liu F. Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry 44: 12546-12553, 2005.
26. Maurer J, Fuchs S, Jager R, Kurz B, Sommer L, Schorle H. Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. Differentiation 75: 580-591, 2007.
27. Michon IN, Penning LC, Molenaar TJ, van Berkel TJ, Biessen EA, Kuiper J. The effect of TGF-beta receptor binding peptides on smooth muscle cells. Biochem Biophys Res Commun 293: 1279-1286, 2002.
28. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801, 2004.
29. Piek E, Heldin CH, Ten Dijke P. Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J 13: 2105-2124, 1999.
30. Raida M, Clement JH, Leek RD, Ameri K, Bicknell R, Niederwieser D, Harris AL. Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. J Cancer Res Clin Oncol 131: 741-750, 2005.
31. Sementchenko VI, Watson DK. Ets target genes: past, present and future. Oncogene 19: 6533-6548, 2000.
32. Shah NM, Groves AK, Anderson DJ. Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85: 331-343, 1996.
33. Stroschein SL, Wang W, Luo K. Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation. J Biol Chem 274: 9431-9441, 1999.
34. Wamhoff BR, Bowles DK, McDonald OG, Sinha S, Somlyo AP, Somlyo AV, Owens GK. L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circ Res 95: 406-414, 2004.
35. Wang G, Matsuura I, He D, Liu F. Transforming growth factor β - inducible phosphorylation of Smad3. J Biol Chem 284: 9663-9673, 2009.
36. Wurdak H, Ittner LM, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W, Sommer L. Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev 19: 530-535, 2005.
37. Xie WB, Li Z, Miano JM, Long X, Chen SY. Smad3-mediated myocardin silencing, a novel mechanism governing the initiation of smooth muscle differentiation. J Biol Chem 286: 15050-15057, 2011.
38. Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394: 909-913, 1998.