Clonal evolution leading to maintenance of antibiotic resistance rates among colonizing pneumococci in the PCV7 era in Portugal

Journal of Clinical Microbiology

Volumn 49, Issue 8, 2011, Pages 2810-2817

  Simões, Alexandra S ^a   Pereira, Liliana ^a   Nunes, Sónia ^a   Brito Avô, António ^b   De Lencastre, Hermínia ^a,c   Sá Leão, Raquel ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b Ministerio da Saude Portuguese   (Portugal)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; CLINDAMYCIN; COTRIMOXAZOLE; ERYTHROMYCIN; PENICILLIN G; PNEUMOCOCCUS VACCINE; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CLONAL VARIATION; CLONE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PORTUGAL; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SEROTYPE; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; CARRIER STATE; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, BACTERIAL; FEMALE; GENOTYPE; HUMANS; INFANT; MALE; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; PORTUGAL; STREPTOCOCCUS PNEUMONIAE;

STREPTOCOCCUS PNEUMONIAE;

EID: 79960964538     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00517-11     Document Type: Article

References (38)

1. Aguiar, S. I., et al. 2010. Denmark14-230 clone as an increasing cause of pneumococcal infection in Portugal within a background of diverse serotype 19A lineages. J. Clin. Microbiol. 48:101-108.
2. Brito, D. A., M. Ramirez, and H. de Lencastre. 2003. Serotyping Streptococcus pneumoniae by multiplex PCR. J. Clin. Microbiol. 41:2378-2384.
3. Brueggemann, A. B., R. Pai, D. W. Crook, and B. Beall. 2007. Vaccine escape recombinants emerge after pneumococcal vaccination in the United States. PLoS Pathog. 3:e168.
4. Carriço, J. A., et al. 2006. Illustration of a common framework for relating multiple typing methods by application to macrolide-resistant Streptococcus pyogenes. J. Clin. Microbiol. 44:2524-2532.
5. CDC. 2005. Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease-United States, 1998-2003. MMWR Morb. Mortal. Wkly. Rep. 54:893-897.
6. CLSI. 2009. Performance standards for antimicrobial susceptibility testing; 19th informational supplement M100-S19. CLSI, Wayne, PA.
7. Cohen, R., et al. 2010. Dynamic of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 introduction in France. Vaccine 28:6114-6121.
8. Dagan, R., N. Givon-Lavi, E. Leibovitz, D. Greenberg, and N. Porat. 2009. Introduction and proliferation of multidrug-resistant Streptococcus pneumoniae serotype 19A clones that cause acute otitis media in an unvaccinated population. J. Infect. Dis. 199:776-785.
9. Enright, M. C., and B. G. Spratt. 1998. A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology 144:3049-3060.
10. Ferech, M., et al. 2006. European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe. J. Antimicrob. Chemother. 58:401-407.
11. Foster, D., et al. 2011. Reduction in invasive pneumococcal disease following implementation of the conjugate vaccine in the Oxfordshire region, England. J. Med. Microbiol. 60:91-97.
12. Frazão, N., et al. 2005. Effect of the seven-valent conjugate pneumococcal vaccine on carriage and drug resistance of Streptococcus pneumoniae in healthy children attending day-care centers in Lisbon. Pediatr. Infect. Dis. J. 24:243-252.
13. Gertz, R. E., Jr., et al. 2010. Increased penicillin nonsusceptibility of non-vaccine-serotype invasive pneumococci other than serotypes 19A and 6A in post-7-valent conjugate vaccine era. J. Infect. Dis. 201:770-775.
14. Goossens, H., M. Ferech, R. Vander Stichele, and M. Elseviers. 2005. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 365:579-587. (Pubitemid 40247914)
15. Hanage, W. P., et al. 2011. Carried pneumococci in Massachusetts children: the contribution of clonal expansion and serotype switching. Pediatr. Infect. Dis. J. 30:302-308.
16. Huang, S. S., et al. 2005. Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004. Pediatrics 116: e408-e413. (Pubitemid 44336655)
17. Lexau, C. A., et al. 2005. Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccine. JAMA 294:2043-2051. (Pubitemid 41539937)
18. Lipsitch, M., et al. 2007. Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. J. Infect. Dis. 196:1221-1227.
19. Mato, R., et al. 2005. Natural history of drug-resistant clones of Streptococcus pneumoniae colonizing healthy children in Portugal. Microb. Drug Resist. 11:309-322.
20. Munoz-Almagro, C., et al. 2009. Emergence of invasive pneumococcal disease caused by multidrug-resistant serotype 19A among children in Barcelona. J. Infect. 59:75-82.
21. Nunes, S., et al. 2005. Trends in drug resistance, serotypes, and molecular types of Streptococcus pneumoniae colonizing preschool-age children attending day care centers in Lisbon, Portugal: a summary of 4 years of annual surveillance. J. Clin. Microbiol. 43:1285-1293.
22. Nunes, S., C. Valente, R. Sá-Leão, and H. de Lencastre. 2009. Temporal trends and molecular epidemiology of recently described serotype 6C of Streptococcus pneumoniae. J. Clin. Microbiol. 47:472-474.
23. O'Brien, K. L., et al. 2009. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 374:893-902.
24. Pai, R., R. E. Gertz, and B. Beall. 2006. Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates. J. Clin. Microbiol. 44:124-131.
25. Pai, R., et al. 2005. Postvaccine genetic structure of Streptococcus pneumoniae serotype 19A from children in the United States. J. Infect. Dis. 192:1988-1995.
26. Park, S. Y., et al. 2008. Impact of conjugate vaccine on transmission of antimicrobial-resistant Streptococcus pneumoniae among Alaskan children. Pediatr. Infect. Dis. J. 27:335-340.
27. Richter, S. S., et al. 2009. Changing epidemiology of antimicrobial-resistant Streptococcus pneumoniae in the United States, 2004-2005. Clin. Infect. Dis. 48:e23-e33.
28. Riedel, S., et al. 2007. Antimicrobial use in Europe and antimicrobial resistance in Streptococcus pneumoniae. Eur. J. Clin. Microbiol. Infect. Dis. 26:485-490.
29. Sá-Leão, R., et al. 2008. High rates of transmission of and colonization by Streptococcus pneumoniae and Haemophilus influenzae within a day care center revealed in a longitudinal study. J. Clin. Microbiol. 46:225-234.
30. Sá-Leão, R., et al. 2009. Changes in pneumococcal serotypes and antibiotypes carried by vaccinated and unvaccinated day-care centre attendees in Portugal, a country with widespread use of the seven-valent pneumococcal conjugate vaccine. Clin. Microbiol. Infect. 15:1002-1007.
31. Sá-Leão, R., et al. 2011. Analysis of invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines reveals heterogeneous behavior of clones expressing the same serotype. J. Clin. Microbiol. 49:1369-1375.
32. Sá-Leão, R., et al. 2000. Carriage of internationally spread clones of Streptococcus pneumoniae with unusual drug resistance patterns in children attending day care centers in Lisbon, Portugal. J. Infect. Dis. 182:1153-1160.
33. Sá-Leão, R., et al. 2000. Genetic diversity and clonal patterns among antibiotic-susceptible and -resistant Streptococcus pneumoniae colonizing children: day care centers as autonomous epidemiological units. J. Clin. Microbiol. 38:4137-4144.
34. Sanchez-Tatay, D., et al. 2008. Antibiotic susceptibility and molecular epidemiology of nasopharyngeal pneumococci from Spanish children. Clin. Microbiol. Infect. 14:797-801.
35. Simonsen, L., et al. 2011. Impact of pneumococcal conjugate vaccination of infants on pneumonia and influenza hospitalization and mortality in all age groups in the United States. mBio 2:e00309-10.
36. Sorensen, U. B. 1993. Typing of pneumococci by using 12 pooled antisera. J. Clin. Microbiol. 31:2097-2100.
37. Sousa, N. G., et al. 2005. Properties of novel international drug-resistant pneumococcal clones identified in day-care centers of Lisbon, Portugal. J. Clin. Microbiol. 43:4696-4703.
38. Vestrheim, D. F., E. A. Hoiby, I. S. Aaberge, and D. A. Caugant. 2010. Impact of a pneumococcal conjugate vaccination program on carriage among children in Norway. Clin. Vaccine Immunol. 17:325-334.