Concomitant use of simvastatin and amiodarone resulting in severe rhabdomyolysis: A case report and review of the literature

Acta Clinica Belgica

Volumn 66, Issue 2, 2011, Pages 134-136

  Marot, A ^a   Morelle, J ^a   Chouinard, V A ^a   Jadoul, M ^a   Lambert, M ^a   Demoulin, N ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Amiodarone; Drug interaction; Rhabdomyolysis; Simvastatin

Indexed keywords

AMIODARONE; SIMVASTATIN; ANTIARRHYTHMIC AGENT; ANTILIPEMIC AGENT; CREATINE KINASE; CYTOCHROME P450 3A;

ADENOVIRUS; AGED; ARTICLE; CASE REPORT; COXSACKIE VIRUS; DISEASE SEVERITY; DRUG WITHDRAWAL; HUMAN; HYPERKALEMIA; LIMB PAIN; LIMB WEAKNESS; MALE; RHABDOMYOLYSIS; TOXOPLASMA; BLOOD; COMORBIDITY; DOSE RESPONSE; DRUG DETOXIFICATION; DRUG INTERACTION; HEART ATRIUM FIBRILLATION; HOSPITALIZATION; HYPERCHOLESTEROLEMIA; METABOLISM; PATHOPHYSIOLOGY; REVIEW; TREATMENT OUTCOME;

AGED, 80 AND OVER; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; COMORBIDITY; CREATINE KINASE; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; HYPERCHOLESTEROLEMIA; HYPOLIPIDEMIC AGENTS; MALE; METABOLIC DETOXICATION, DRUG; RHABDOMYOLYSIS; SEVERITY OF ILLNESS INDEX; SIMVASTATIN; TREATMENT OUTCOME;

EID: 79960961358     PISSN: 00015512     EISSN: None     Source Type: Journal    
DOI: 10.2143/ACB.66.2.20625533     Document Type: Article

References (5)

1. Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA 2003; 289: 1681-1690. (Pubitemid 37430274)
2. Bellosta S, Paoletti R, Corsini A. Safety of statins: focus on clinical pharmacokinetics and drug interactions. Circulation 2004; 109: 50-57.
3. Rowan C, Brinker AD, Nourjah P et al. Rhabdomyolysis reports show interaction between simvastatin and CYP3A4 inhibitors. Pharmacoepidemiol Drug Saf 2009; 18: 301-309.
4. Borders-Hemphill V. Concurrent use of statins and amiodarone. Consult Pharm 2009; 24: 372-379.
5. Schmidt GA, Hoehns JD, Purcell JL, Friedman RL, Elhawi Y. Severe rhabdomyolysis and acute renal failure secondary to concomitant use of Simvastatin, Amiodarone, and Atazanavir. J Am Board Fam Med 2007; 20: 411-416. (Pubitemid 47173856)