Transgenic expression of full-length 2',5'-oligoadenylate synthetase 1b confers to BALB/c mice resistance against West Nile virus-induced encephalitis

Virology

Volumn 417, Issue 1, 2011, Pages 147-153

  Simon Chazottes, Dominique ^a,b   Frenkiel, Marie Pascale ^a   Montagutelli, Xavier ^a,b   Guénet, Jean Louis ^a   Desprès, Philippe ^a   Panthier, Jean Jacques ^a,b  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

Author keywords

Antiviral effect; Encephalitis; Flavivirus; Genetic deficiency; Genetic determinant; Inbred strains; Innate resistance; Mouse; OAS; Transgenesis

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETHASE 1B; COMPLEMENTARY DNA; LYASE; MESSENGER RNA; UNCLASSIFIED DRUG;

2',5' OLIGOADENYLATE SYNTHETHASE 1B GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CODON; CONTROLLED STUDY; GENE; GENE FREQUENCY; GENE OVEREXPRESSION; MORTALITY; MOUSE; NEUROPROTECTION; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSGENIC MOUSE; TRANSGENICS; VIROGENESIS; VIRUS ENCEPHALITIS; VIRUS EXPRESSION; VIRUS INDUCTION; VIRUS RESISTANCE; VIRUS STRAIN; VIRUS TRANSMISSION; WEST NILE FLAVIVIRUS;

2',5'-OLIGOADENYLATE SYNTHETASE; ANIMALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC ENGINEERING; GENETIC PREDISPOSITION TO DISEASE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; RNA, MESSENGER; WEST NILE FEVER; WEST NILE VIRUS;

FLAVIVIRUS; MURINAE; MUS; MUS MUSCULUS; WEST NILE VIRUS;

EID: 79960945082     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2011.05.018     Document Type: Article

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