Nicorandil associated colonic ulceration: Case series of an increasingly recognized complication

Digestive Diseases and Sciences

Volumn 56, Issue 8, 2011, Pages 2404-2408

  Lee, Bee C ^a   Allen, Patrick B ^b   Caddy, Grant R ^c   Mainie, Inder ^b  

^a South Eastern Health and Social Care Trust   (United Kingdom)

^b BELFAST CITY HOSPITAL   (United Kingdom)

^c ULSTER HOSPITAL   (United Kingdom)

Author keywords

Colon; Colonic ulceration; Nicorandil; Ulcer

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; C REACTIVE PROTEIN; CLOPIDOGREL; FERRITIN; HEMOGLOBIN; NICORANDIL; SOTALOL;

ABDOMINAL PAIN; ABDOMINAL RADIOGRAPHY; ACUTE DIARRHEA; AGED; ANAL ULCER; ANGINA PECTORIS; ARTICLE; BLOOD SAMPLING; BRONCHOPNEUMONIA; CAUSE OF DEATH; CECUM ULCER; CHRONIC DIARRHEA; CHRONIC INFLAMMATION; CLINICAL ARTICLE; COLON BIOPSY; COLON MUCOSA; COLON ULCER; COLONOSCOPY; COMPUTER ASSISTED TOMOGRAPHY; DESCENDING COLON; DIARRHEA; DRUG DOSE INCREASE; DRUG WITHDRAWAL; ENTERITIS; FEMALE; FERRITIN BLOOD LEVEL; GASTROSCOPY; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; ILEOCECAL VALVE; INFLAMMATORY CELL; INTESTINE BIOPSY; IRON DEFICIENCY ANEMIA; ISCHEMIC COLITIS; ISCHEMIC HEART DISEASE; LEUKOCYTE COUNT; MALE; MOUTH ULCER; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PRIORITY JOURNAL; RECTUM ULCER; SIDE EFFECT; SIGMOIDOSCOPY; TRANSVERSE COLON; ULCER HEALING; ULCERATIVE COLITIS; WEIGHT REDUCTION;

AGED; AGED, 80 AND OVER; BIOPSY; COLONIC DISEASES; COLONOSCOPY; FEMALE; HUMANS; MALE; MYOCARDIAL ISCHEMIA; NICORANDIL; TREATMENT OUTCOME; ULCER; VASODILATOR AGENTS;

EID: 79960939137     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1634-x     Document Type: Article

References (24)

1. IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: the Impact of Nicorandil in Angina (IONA) randomised trial [published correction appears in Lancet 2002; 360:806]. Lancet. 2002;359:1269-1275.
2. Boulinguez S, Bedane C, Bouyssou-Gauthier M, et al. Giant buccal aphthosis caused by nicorandil. Presse Med. 1997;26:558. (Pubitemid 27207158)
3. Healy CM, Smyth Y, Flint SR. Persistent nicorandil induced oral ulceration. Heart. 2004;90:38.
4. Watson A, Al-Ozairi O, Fraser A, Loudon M, O'Kelly T. Nicorandil associated anal ulceration. Lancet. 2002;360:546-547. (Pubitemid 35232111)
5. Vella M, Molloy RG. Nicorandil-associated anal ulceration. Lancet. 2002;360:1979.
6. Baker RP, Al-Kubati W, Atuf M, Philips RKS. Nicorandil-induced severe perianal ulceration. Tech Coloproctol. 2007;11:343-345.
7. Cooke NS, Tolland JP, Dolan OM. Nicorandil-associated perianal ulceration: a case series of 10 patients. Br J Dermatol. 2006;154:199-200. (Pubitemid 43381353)
8. Titi MA, Seow C, Molloy RG. Nicorandil-induced colonic ulceration: A new cause of colonic ulceration. Report of four cases. Dis Colon Rectum. 2008;51:1570-1573.
9. Brown R, Lee A, Welfare M. Nicorandil-induced colonic ulceration. Heart. 2008;94:678. (Pubitemid 351580150)
10. Egred M, Andron M, Morrison WL. Nicorandil may be associated with gastrointestinal ulceration. BMJ. 2006;332:889. (Pubitemid 44365586)
11. King PM, Suttie SA, Jansen JO, Watson AJ. Perforation of the terminal ileum: a possible complication of nicorandil therapy. Surgery. 2004;2:56-57. (Pubitemid 38219607)
12. Swinscoe MT, Savani R, Lobo AJ, Stephenson TJ, Shorthouse AJ. Nicorandil-induced terminal ulceration - a probable link. BMJ Case Reports. Available at: http://casereports.bmj.com. Published May 31, 2010.
13. Malde S, Wilson A. Rectal ulceration caused by the anti-anginal nicorandil: Case report of a preventable complication. Patient Saf Surg. 2010;4:10.
14. Yang J, Adams JD Jr. Structure activity relationships for nicotinamide in the treatment of stroke. Lett Drug Des Discov. 2004;1:58-65.
15. Aftab AR, Donnellan F, Zeb F, Kevans D, Cullen G, Courtney G. NSAID-colopathy. A case series. J Gastrointestin Liver Dis. 2010;19:89-91.
16. Püspök A, Kiener HP, Oberhuber G. Clinical, endoscopic and histologic spectrum of nonsteroidal anti-inflammatory drug-induced lesions in the colon. Dis Colon Rectum. 2000;43:685-691. (Pubitemid 30324609)
17. Kurahara K, Matsumoto T, Iida M, Honda K, Yao T, Fujishima M. Clinical and endoscopic features of nonsteroidal anti-inflammatory drug-induced colonic ulcerations. Am J Gastroenterol. 2001;96:473-480.
18. Hebuterne X, Dreyfus G, Fratini G, et al. Nonsteroidal anti-inflammatory drug-induced colitis and misoprostol. Dig Dis Sci. 1996;41:520-521. (Pubitemid 26117553)
19. Van Gossum A, et al. Anorectal stenosis in patients with prolonged use of suppositories containing paracetamol and acetylsalicylic acid. Dig Dis Sci. 1993;38:1970-1977. (Pubitemid 23336557)
20. Cappell MS, Simon T. Colonic toxicity of administered medications and chemicals. Am J Gastroenterol. 1993;88:1684-1699.
21. Linder JD, Mönkermüller KE, Raijmale I, et al. Cocaine-associated ischemic colitis. South Med J. 2000;93:909-913.
22. Brown DN, Rosenholtz MJ, Marshall JB. Ischemic colitis related to cocaine abuse. Am J Gastroenterol. 1994;89:1558-1561. (Pubitemid 24313054)
23. Moawad FJ, Goldkind L. An unusual case of colonic ischemia. South Med J. 2009;102:405-407.
24. Hodge JA, Hodge KD. Ischemic colitis related to sumatriptan overuse. J Am Board Fam Med. 2010;23:124-127.