Cardio protective hypolipidemic activity of amino guanidine against streptozo-tocin induced diabetic mice heart (an in vivo) and high glucose induced lipid ac-cumulation cardiac fibroblasts (an in vitro study)

International Journal of Research in Pharmaceutical Sciences

Volumn 2, Issue 3, 2011, Pages 421-428

  Vadla, Gangadhar Prasadachari ^a   Kumarasamy, Nehru ^a   Vellaichamy, Elangovan ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Aminoguanidine; Glucose; Phospholipids; Streptozotocin; Triglycerides

Indexed keywords

AMINOGUANIDINE; ANTILIPEMIC AGENT; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LYSATE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; HEART CELL CULTURE; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; LIPOGENESIS; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 79960934109     PISSN: None     EISSN: 09757538     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Balistreri, C. R., Caruso, C., & Candore, G. The role of adipose tissue and adipokines in obesity-related in-flammatory diseases. Mediators Inflamm, 2010, 802078.
2. Bartlett, G. R. (1959) Phosphorus assay in column chromatography. J Biol Chem, 234, 466-468.
3. Bedekar, A., Shah, K., & Koffas, M. Natural products for type II diabetes treatment. Adv Appl Microbiol, 71, 21-73.
4. Caterson, I. D., Hubbard, V., Bray, G. A., Grunstein, R., Hansen, B. C., Hong, Y., et al. (2004) Prevention Con-ference VII: Obesity, a worldwide epidemic related to heart disease and stroke: Group III: worldwide com-orbidities of obesity. Circulation, 110, e476-483.
5. Cusi, K., Kashyap, S., Gastaldelli, A., Bajaj, M., & Cerso-simo, E. (2007) Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes. Am J Physiol Endo-crinol Metab, 292, E1775-1781.
6. Eckel, R. H. (1997) Obesity and heart disease: a state-ment for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation, 96, 3248-3250.
7. Fabbrini, E., Sullivan, S., & Klein, S. Obesity and nonal-coholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology, 51, 679-689.
8. Fatehi-Hassanabad, Z., & Chan, C. B. (2005) Transcrip-tional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic beta-cell function. Nutr Metab (Lond), 2, 1.
9. Folch, J., Lees, M., & Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem, 226, 497-509.
10. Frayn, K. N., Karpe, F., Fielding, B. A., Macdonald, I. A., & Coppack, S. W. (2003) Integrative physiology of human adipose tissue. Int J Obes Relat Metab Disord, 27, 875-888.
11. Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem, 18, 499-502.
12. Johnson, R. J., Segal, M. S., Sautin, Y., Nakagawa, T., Feig, D. I., Kang, D.H., et al. (2007)
13. Lehtonen, H. M., Jarvinen, R., Linderborg, K., Viitanen, M., Venojarvi, M., Alanko, H., et al. Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophae rhamnoides ssp. turkesta-nica) berry and its ethanol-soluble metabolites. Eur J Clin Nutr, 64, 1465-1471.
14. Leichman, J. G., Aguilar, D., King, T. M., Vlada, A., Reyes, M., & Taegtmeyer, H. (2006) Association of plasma free fatty acids and left ventricular diastolic function in patients with clinically severe obesity. Am J Clin Nutr, 84, 336-341.
15. Lewis, G. F., Carpentier, A., Adeli, K., & Giacca, A. (2002) Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 di-abetes. Endocr Rev, 23, 201-229.
16. Maiorana, A., Del Bianco, C., & Cianfarani, S. (2007) Adipose Tissue: A Metabolic Regulator. Potential Im-plications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA). Rev Diabet Stud, 4, 134-146.
17. Montessuit, C., Papageorgiou, I., Tardy-Cantalupi, I., Rosenblatt-Velin, N., & Lerch, R. (2000) Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer. J Appl Physiol, 89, 111-119.
18. Oak, J. H., Youn, J. Y., & Cai, H. (2009) Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice. Cardiovasc Diabetol, 8, 65.
19. Panagiotopoulos, S., O'Brien, R. C., Bucala, R., Cooper, M. E., & Jerums, G. (1998) Aminoguanidine has an anti-atherogenic effect in the cholesterol-fed rabbit. Atherosclerosis, 136, 125-131.
20. Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science, 284, 143-147.
21. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr, 86, 899-906.
22. Prevot, D., Soltesz, Z., Abello, V., Wanecq, E., Valet, P., Unzeta, M., et al. (2007) Prolonged treatment with aminoguanidine strongly inhibits adipocyte semicar-bazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats. Pharmacol Res, 56, 70-79.
23. Rita Costa, A., Elisa Rodrigues, M., Henriques, M., Aze-redo, J., & Oliveira, R. Guidelines to cell engineering for monoclonal antibody production. Eur J Pharm Bi-opharm, 74, 127-138.
24. Ruberg, F. L. (2007) Myocardial lipid accumulation in the diabetic heart. Circulation, 116, 1110-1112.
25. Scheuer, J. (1967) Myocardial metabolism in cardiac hypoxia. Am J Cardiol, 19, 385-392.
26. Schulze, P. C. (2009) Myocardial lipid accumulation and lipotoxicity in heart failure. J Lipid Res, 50, 2137-2138.
27. Slawik, M., & Vidal-Puig, A. J. (2006) Lipotoxicity, over-nutrition and energy metabolism in aging. Ageing Res Rev, 5, 144-164.
28. Stanley, W. C., Recchia, F. A., & Lopaschuk, G. D. (2005) Myocardial substrate metabolism in the normal and failing heart. Physiol Rev, 85, 1093-1129.
29. Suthar, M., Rathore, G. S., & Pareek, A. (2009) Antioxi-dant and Antidiabetic Activity of Helicteres isora (L.) Fruits. Indian J Pharm Sci, 71, 695-699.
30. Takeuchi, M., Takino, J., & Yamagishi, S. Involvement of the toxic AGEs (TAGE)-RAGE system in the pathoge-nesis of diabetic vascular complications: a novel the-rapeutic strategy. Curr Drug Targets, 11, 1468-1482.
31. Tripathi, B. K., & Srivastava, A. K. (2006) Diabetes melli-tus: complications and therapeutics. Med Sci Monit, 12, RA130-147.
32. Trivedi, P. S., & Barouch, L. A. (2008) Cardiomyocyte apoptosis in animal models of obesity. Curr Hyper-tens Rep, 10, 454-460.
33. Turpin, S. M., Ryall, J. G., Southgate, R., Darby, I., He-vener, A. L., Febbraio, M. A., et al. (2009) Examina-tion of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice. J Physiol, 587, 1593-1605.
34. Van Handel, E., & Zilversmit, D. B. (1957) Micromethod for the direct determination of serum triglycerides. J Lab Clin Med, 50, 152-157.
35. van Herpen, N. A., & Schrauwen-Hinderling, V. B. (2008) Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav, 94, 231-241.
36. Vaughan, T. B., & Bell, D. S. (2006) Diabetic cardiomyo-pathy. Heart Fail Clin, 2, 71-80.
37. Wang, X., Chang, T., Jiang, B., Desai, K., & Wu, L. (2007) Attenuation of hypertension development by amino-guanidine in spontaneously hypertensive rats: role of methylglyoxal. Am J Hypertens, 20, 629-636.
38. Wang, Y., Huang, Y., Lam, K. S., Li, Y., Wong, W. T., Ye, H., et al. (2009) Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilata-tion via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardio-vasc Res, 82, 484-492.
39. Wende, A. R., & Abel, E. D. Lipotoxicity in the heart. Biochim Biophys Acta, 1801, 311-319.
40. Zlatkis, A., Zak, B., & Boyle, A. J. (1953) A new method for the direct determination of serum cholesterol. J Lab Clin Med, 41, 486-492.