Measurement of long lived radioactive impurities retained in the disposable cassettes on the Tracerlab MX system during the production of [ 18F]FDG

Applied Radiation and Isotopes

Volumn 69, Issue 10, 2011, Pages 1479-1485

  Ferguson, D ^a   Orr, P ^a   Gillanders, J ^a   Corrigan, G ^a   Marshall, C ^a  

^a ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

Author keywords

Cyclotron; FDG; Radioactive waste; Waste disposal

Indexed keywords

CLINICAL WASTE; DECAY CORRECTION; DISPOSABLE CASSETTES; FDG; MINIMUM TIME; RADIOACTIVE IMPURITIES; SPECIFIC ACTIVITY;

GAMMA RAYS; GERMANIUM; RADIOACTIVE WASTES; RADIOACTIVITY; RADIOISOTOPES; WASTE DISPOSAL;

RADIOACTIVE WASTE DISPOSAL;

FLUORODEOXYGLUCOSE F 18; GERMANIUM; RADIOACTIVE MATERIAL; RADIOISOTOPE;

ARTICLE; CONTROLLED STUDY; DISPOSABLE EQUIPMENT; GAMMA SPECTROMETRY; ISOTOPE ANALYSIS; LABORATORY; PRIORITY JOURNAL; RADIATION MEASUREMENT; RADIOACTIVE WASTE DISPOSAL; RADIOCHEMISTRY; RADIOISOTOPE DECAY;

ALLOYS; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; MEDICAL WASTE DISPOSAL; RADIOPHARMACEUTICALS; SPECTROMETRY, GAMMA;

EID: 79960932081     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2011.05.028     Document Type: Article

References (17)

1. Bowden L., Leo'n Vintró L., Mitchell P.I., O'Donnell R.G., Seymour A.M., Duffy G.J. Radionuclide impurities in proton-irradiated [18O]H2O for the production of 18F-: activities and distribution in the [18F]FDG synthesis process. Appl. Radiat. Isot. 2009, 67:248-255.
2. BP, 2010. Monographs: radiopharmaceutical preparation, fluorodeoxyglucose [18F] injection. In: British Pharmacopoeia 2010, British Pharmacopoeia Commission, London.
3. Dickson, J.M., Randle, T.C., 1951. The excitation function for the production of 7Be by the bombardment of 12C by protons. In: Proceedings of the Physical Society Section A, vol. 64, p. 902.
4. Ditrói F., Hermanne A., Corniani E., Takacs S., Tarkanyi F., Csikai J., Shubin Y.N. Investigation of proton induced reactions on niobium at low and medium energies. Nucl. Inst. Methods Phys. Res. B 2009, 267(19):3364-3374.
5. Department of Health, 2007. Policy for the Long Term Management of Solid Low Level Radioactive Waste in the United Kingdom.
6. EP, 2010 Flurodeoxyglucose [18F] injection. European Pharmacopoiea, European Directorate for the Quality of Medicines, Strasbourg, France.
7. Gagnon, K., Wilson, J.S., McQuarrie, A., Comparison of Nb, Pt, Ta, Ti, Zr and ZrO2 sputtered havar foils for the high power cyclotron production of reactive [18F]F-, In: Proceedings of the 13th International Workshop of Targetry and Target Chemistry, Roskilde, Denmark, 2010.
8. Gillies J.M., Najim N., Zweit J. Analysis of metal radioisotope impurities generated in [18O]H2O during the cyclotron production of fluorine-18. Appl. Radiat. Isot. 2006, 64:431-434.
9. Havar Technical Data Sheet, Hamilton Precision Metals, Lancaster, PA, http://www.hpmetals.com/pdfs/havar.pdf.
10. Hichwa R.D., Kadrmas D., Watkins G.L., Wollenweber S.D., Maniam S., Boles Ponto L.L., Richmond J.C.W., Koeppel J.A. Vanadium-48: A Renewable Source for Transmission Scanning with PET. Nucl. Inst. Methods Phys. Res. B 1995, 99:804-806.
11. Ito S., Sakane H., Deji S., Saze T., Nishizawa K. Radioactive byproducts in [18O]H2O used to produce 18F for [18F]FDG synthesis. Appl. Radiat. Isot. 2006, 64:298-305.
12. Lapi S., Mills W.J., Wilson J., McQuarrie S., Publicover J., Schueller M., Schyler D., Ressler J.J., Ruth T.J. Production cross-sections of 181-186Re isotopes from proton bombardment of natural tungsten. Appl. Radiat. Isot. 2007, 65:345-349.
13. Marengo M., Lodi F., Magi S., Cicoria G., Pancaldi D., Boschi S. Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) routine production. Appl. Radiat. Isot. 2008, 66:295-302.
14. Mochizuki S., Ogata Y., Hatano K., Abe J., Ito K., et al. Measurement of the Induced Radionuclides in Production of Radiopharmaceuticals for Positron Emission Tomography. J. Nucl. Sci. Technol. 2006, 43:348-353.
15. O'Donnell R.G., Leo'n Vintro' L., Duffy G.J., Mitchell P.I. Measurement of the residual radioactivity induced in the front foil of a target assembly in a modern medical cyclotron. Appl. Radiat. Isot. 2004, 60:539-542.
16. Wilson J.S., Avila-Rodriguez M.A., Johnson R.R., Zyuzin A., McQuarrie S.A. Niobium sputtered Havar foils for the high-power production of reactive [18F]fluoride by proton irradiation of [18O]H2O targets. Appl. Radiat. Isot. 2008, 66:565-570.
17. Yu S. Review of 18F-FDG synthesis and quality control. Biomed. Imaging Interv. J. 2006, 2:4.